ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Immunosuppression"

  • 2015 American Transplant Congress

    In Vivo Expansion of Donor-Specific Regulatory T Cells by a New Triazolopyrimidine Derivative and Donor-Specific Transfusion

    S. Emoto,1 R. Goto,1 S. Shibasaki,1 A. Nagatsu,1 H. Ono,1 R. Igarashi,1 M. Fukai,2 T. Shimamura,3 K. Saiga,4 M. Murakami,5 A. Taketomi,1 S. Todo,6 K. Yamashita.2

    1Gastroenterological Surgery 1, Hokkaido University, Sapporo, Japan; 2Transplant Surgery, Hokkaido University, Sapporo, Japan; 3Division of Organ Transplantation, Hokkaido University Hospital, Sapporo, Japan; 4Nippon Kayaku, Tokyo, Japan; 5Institute for Genetic Medecine, Hokkaido University, Sapporo, Japan; 6Research Institute, St. Mary Hospital, Kurume, Japan.

    Background: We have previously demonstrated that a new triazolopyrimidine derivative, NK026680 (NK) prevents activation/maturation of dendritic cells. This study investigated whether NK together with donor-specific…
  • 2015 American Transplant Congress

    TIM-4 Identifies IL-17 Expressing Pro-Inflammatory Be-17 Cells That Promote Allograft Rejection

    Q. Ding, K. Mohib, D. Rothstein.

    Thomas E. Starzl Transplantation Institute, University of Pittsburgh Medical Center, Pittsburgh, PA.

    We identified TIM-1 as an inclusive marker for IL-10+ regulatory B cells (TIM-1+ Bregs), which prolong islet allograft survival (GS). We recently found that TIM-4,…
  • 2015 American Transplant Congress

    Everolimus Initiation Immediately After Liver Transplantation: A Single-Center Experience

    U. Herden, A. Galante, S. Pischke, L. Fischer, J. Li, M. Koch, E. Achilles, B. Nashan, M. Sterneck.

    University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

    BackgroundClinical trials in liver transplant (LTX) patients with randomization on day 30 to everolimus (EVR) show a benefit in renal function compared to calcineurin inhibitor…
  • 2015 American Transplant Congress

    De Novo Donor-Specific HLA Antibodies After Kidney Transplantation Are Associated With Donation After Circulatory Death and HLA-DQ Mismatch

    G. Dreyer,1 D. Roelen,2 S. Brand-Schaaf,2 O. Dekkers,3 M. Reinders,1 F. Claas,2 J. de Fijter.1

    1Nephrologie, LUMC, Leiden, Netherlands; 2Immunohaematology and Blood Transfusion, LUMC, Leiden, Netherlands; 3Clinical Epidemiology, Aarhus Medical Center, Aarhus C, Denmark.

    Introduction: De novo donor-specific HLA-antibodies (dnDSA) have been associated with rejection and inferior kidney graft survival. The purpose of this study was to investigate the…
  • 2015 American Transplant Congress

    Neurocognitive Profile of Children Born to Kidney Transplant Recipients Mothers

    L. Morales-Buenrostro,1 S. Sanchez-Roman,1 S. Lascarez,1 A. Niebla-Cardenas,1 D. Lopez-Carrillo,1 G. Caballero-Andrade,1 A. Velez,4 R. Espinoza,2 E. Mancilla-Urrea,3 J. Alberu.1

    1INCMNSZ, Mexico City, Mexico; 2Centro Medico Nacional Siglo XXI, Mexico City, Mexico; 3Instituto Nacional de Cardiologia, Mexico City, Mexico; 4Universidad Nacional Autonoma de Mexico, Mexico City, Mexico.

    Aim. To compare neurocognitive abilities of children of kidney transplant (KT) recipients who were exposed to immunosuppression during pregnancy with unexposed children. Methods. In this…
  • 2015 American Transplant Congress

    Chimerism for Early Detection of Graft Versus Host Disease in Intestinal Transplantation

    J. Garcia, T. Beduschi, P. Ruiz, A. Tekin, J. Fan, S. Nishida, G. Selvaggi, L. Cubley, R. Vianna.

    Miami Transplant Institute, University of Miami Miller School of Medicine, Miami, FL.

    Graft versus host disease (GVHD) is a potentially fatal complication after multivisceral transplantation (MVT). By definition, donor cells must be present in the blood of…
  • 2015 American Transplant Congress

    Lipid Profiles Over 2 Years Follow-Up in De Novo Kidney Transplant Recipients Randomized to Once-Daily MeltDose® Tacrolimus (Envarsus® XR) Vs. Twice-Daily Tacrolimus (Prograf®): Results from a Phase 3, Double-Blind, Double-Dummy, Multicenter Trial

    S. Mulgaonkar, O. Pankewycz, S. Steinberg.

    St. Barnabas Medical Center, Livingston; Erie County Medical Center, Buffalo; California Institute of Renal Research, San Diego.

    Cardiovascular disease (CVD) is a leading cause of death in kidney transplant recipients (KTR). Focusing on modifiable CVD risk factors is key to decreasing CVD-related…
  • 2015 American Transplant Congress

    Combined Anti-IL6R and CTLA4Ig Therapy Attenuates Recall Alloantibody Responses in a Mouse Model of HLA Sensitization

    N.-N. Chai, G. Wu, I. Kim, A. Klein, S. Jordan.

    Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA.

    [bald]Background[/bald] We previously reported that IL-6 inhibition by anti-IL6R antibody (mMR16-1) or CD28 pathway inhibition using CTLA4Ig (abatacept) reduced recall alloantibody responses in a mouse…
  • 2015 American Transplant Congress

    Inadequate Overall Immunosuppression Is a Risk for Late Acute Rejection Despite Alemtuzumab Induction in Simultaneous Pancreas Kidney Transplant Recipients

    J. Bank,1 M. Mallat,1 P. van der Boog,1 D. Braat,2 J. Ringers,2 M. Vergunst,3 S. Heidt,3 F. Claas,3 M. Reinders,1 J. de Fijter.1

    1Nephrology, LUMC, Leiden, Netherlands; 2Surgery, LUMC, Leiden, Netherlands; 3IHB, LUMC, Leiden, Netherlands.

    Introduction: Simultaneous pancreas-kidney transplantation (SPK) has become the treatment of choice for patients with end-stage renal disease due to Type 1 Diabetes Mellitus. SPK is…
  • 2015 American Transplant Congress

    Pregnancy Outcomes in Solid Organ Transplant Recipients With Exposure to Sirolimus Without Mycophenolate

    N. Sifontis,1 L. Coscia,2 D. Armenti,2 S. Constantinescu,2,3 M. Moritz.2,4

    1Pharmacy Practice, Temple University, Philadelphia; 2National Transplantation Pregnancy Registry, Gift of Life Institute, Philadelphia; 3Temple University School of Medicine, Philadelphia; 4Lehigh Valley Health Network, Allentown.

    Results of prior sirolimus series reports have been confounded by concomitant mycophenolate exposure. The purpose of this study was to describe pregnancy outcomes with exposure…
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