2015 American Transplant Congress
Efficacy, Safety and Pharmacokinetics of Once-Daily, MeltDose® Tacrolimus (Envarsus® XR) Versus Twice-Daily Tacrolimus (Prograf®) in De Novo Kidney Transplant Recipient Sub-Groups: A 2 Year Phase 3 Randomized, Double-Blind, Double-Dummy, Trial
Differences in tacrolimus (tac) metabolism are evident in certain populations; in particular, lower tac bioavailability has been shown in females and black kidney transplant recipients…2015 American Transplant Congress
Identification of Genetic Variants Associated With Variation of Tacrolimus Levels in African Americans Using GWAS
African American kidney transplant recipients (AA) have a higher incidence of allograft failure when compared to Caucasians. We have previously reported that tacrolimus troughs (TT)…2015 American Transplant Congress
Rituximab With Intravenous Immune Globulin in Sensitized Patients Awaiting Heart Transplant: Does It Work?
Cedars-Sinai Heart Institute, Los Angeles, CA.
Purpose: Highly sensitized heart transplant (HTx) recipients with donor specific antibodies (DSA) are at increased risk of rejection and death. Rituximab with Intravenous Immune Globulin…2015 American Transplant Congress
CTLA4Ig Administered During T-Cell Priming Negates de novo Alloantibody Responses and Modulates Recall Antibody Production
Comprehensive Transplant Center, Cedars-Sinai Medical Center, Arcadia, CA.
Background CTLA4Ig (Belatacept) is a novel anti-rejection therapy aimed at costimulatory blockade. Clinical data suggest that post-transplant alloantibody formation is also reduced in patients treated…2015 American Transplant Congress
Comparison of Efficacy and Renal Function in KidneyTransplant Recipients Receiving Tacrolimus (TAC)-Based Immunosuppressive Regimens in Combination With Everolimus (EVR) or Mycophenolate (MPA)
1Nephrology, Hospital do Rim UNIFESP, Sao Paulo, Brazil; 2Pathology, UNIFESP, Sao Paulo, Brazil.
Introduction: Acute rejection and renal function are associated with long-term renal allograft survival. We evaluated these outcomes in patients receiving reduced TAC exposure combined with…2015 American Transplant Congress
Pharmacokinetics of Mycophenolic Acid (MPA) in Elderly Compared to Young Recipients in the First Year After Renal Transplantation. Data from the NEverOLd Trial
Elderly (≥60years) recipients are nowadays receiving renal transplants more frequently. The pharmacokinetics studies (PK) of immunosuppressive drugs in healthy volunteers, rarely, if ever, include old…2015 American Transplant Congress
Comparison of T Regulatory (Treg) Cell Function Pre- and Post-Lung Transplantation Shows a Major Negative Impact of Immunosuppression on Treg Function
Aim: Clinical lung Tx recipients do not have sustained long-term survival outcomes comparable to that of other recipients of solid organ allografts, despite generally comparable…2015 American Transplant Congress
Stable and Unstable Chimerism During Immunosuppressive Drug Withdrawal in Tolerant Recipients of HLA Matched Combined Kidney and Hematopoietic Cell Transplants
1Surgery, Stanford University, Palo Alto, CA; 2Medicine, Stanford University, Palo Alto, CA.
Our previous studies showed that 75-80% of HLA matched recipients of combined kidney and hematopoietic cell transplants conditioned with total lymphoid irradiation (TLI) and anti-thymocyte…2015 American Transplant Congress
Everolimus and Early Calcineurin Inhibitor Withdrawal Is Associated With Superior Renal Function: 5-Year Follow-Up of the Randomized PROTECT Liver Transplantation Study
PROTECT Study Group, Novartis Pharma GmbH, Germany.
Purpose: At the end of the 12-month (M) PROTECT core study (NCT00378014), de novo liver transplant recipients (LTxR) who switched from a calcineurin inhibitor (CNI)…2015 American Transplant Congress
Proximal Tubular Dysfunction Is Common After the First Year of Kidney Transplantation
Background: After the initial period of kidney transplantation, the prevalence of proximal tubular dysfunction (PTD) and its consequences are unknown. The aim of this study…
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