Articles tagged "Immunosuppression"

2015 American Transplant Congress
Longterm Outcome in Pancreas Grafts After Polyomavirus Infection in Combined Kidney-Pancreas Transplants: A Single Center Report
C. Boesmueller,¹ C. Margreiter,¹ M. Rudnicki,² R. Oellinger,³ S. Schneeberger,¹ M. Maglione.¹
¹Transplant Surgery, University Hospital, Innsbruck, Austria; ²Nephrology, University Hospital, Innsbruck, Austria; ³General Surgery, University Charité Virchow Hospital, Berlin, Germany.
Purpose: We retrospectively analyzed the longterm survival and function in pancreas grafts after reduction of immunosuppression due to polyomavirus infection in simultaneous pancreas kidney transplants…
2015 American Transplant Congress
Antithymocyte Globulin-Induced Platelet Hypercoagulability Is a Consequence of Complement Activation and Microvesicle Release
D. Zecher,^1,4 A. Cumpelik,¹ D. Tsakiris,² M. Dickenmann,³ J. Schifferli.¹
¹Department of Research, Basel University Hospital, Basel, Switzerland; ²Department of Hematology, Basel University Hospital, Basel, Switzerland; ³Department of Nephrology, Basel University Hospital, Basel, Switzerland; ⁴Department of Nephrology, Regensburg University Hospital, Regensburg, Germany.
T cell depletion with antithymocyte globulins (ATG) can be complicated by thrombopenia andhypercoagulability. The underlying mechanism is still unclear. We found that binding of ATG…
2015 American Transplant Congress
Conversion from Immediate to Prolonged Release Tacrolimus Did Not Change Intra-Patient Variability in Renal Transplant Patients
T. El-Nahhas,^1,2 M. Moreton,² J. Popoola,³ S. Abat,³ A. Johnston,^1,2 I. MacPhee.³
¹Clinical Pharmacology Department, William Harvey Research Institute, Barts and The London, Queen Mary University of London, London, United Kingdom; ²Analytical Services International, St. George's University of London, London, United Kingdom; ³Institute of Medical and Biomedical Education-Renal Medicine, St. George's University of London, London, United Kingdom.
Background. Tacrolimus has a narrow therapeutic index and is characterized by a large inter- and intra-patient variability (IPV). Variable blood tacrolimus concentrations have been shown…
2015 American Transplant Congress
Electronic Health Service to Improve Therapeutic Drug Monitoring of Immunosuppressants
M. Barten,¹ J. Garbade,² I. Hausladen,² F. Mohr.²
¹Cardiovascular Surgery, University Heart Center Hamburg, Hamburg, Germany; ²Cardiac Surgery, University Leipzig Heart Center, Leipzig, Germany.
PurposeTherapeutic drug monitoring (TDM) of immunosuppressants is critical to avoid rejection or toxic side effects by under- or over-immunosuppression after heart transplantation (HTx). Hence, in…
2015 American Transplant Congress
The Use of Eculizumab to Treat the Highly Sensitized Patient Awaiting Heart Transplant
J. Patel, D. Dilibero, M. Kittleson, S. Sana, F. Liou, D. Chang, A. Hage, L. Czer, A. Trento, N. Reinsmoen, J. Kobashigawa.
Cedars-Sinai Heart Institute, Los Angeles, CA.
Purpose: Highly sensitized patients (pts) awaiting heart transplantation remain a significant challenge due to prolonged often prohibitive wait times for suitable organs and increased rejection…
2015 American Transplant Congress
Everolimus Versus Mycophenolate for Recipients of Kidney Transplants from Expanded Criteria Donors (ECD) Receiving Anti-Thymocyte Globulin and Tacrolimus
H. Tedesco-Silva,¹ C. Felipe,¹ A. Ferreira,¹ M. Cristelli,¹ A. Bessa,¹ P. Ueno,¹ T. Sandes- Freitas,¹ G. Bassos,¹ W. Aguiar,² H. Proença,³ J. Medina-Pestana.¹
¹Nephrology, Hospital do Rim UNIFESP, Sao Paulo, Brazil; ²Urology, Hospital do Rim UNIFESP, Sao Paulo, Brazil; ³Pathology, UNIFESP, Sao Paulo, Brazil.
Introduction: Recipients of kidneys recovered from expanded criteria donors are at higher risk to develop delayed graft function (DGF) and acute rejection (AR), leading to…
2015 American Transplant Congress
CD28-Directed Therapy Prolongs Survival in a Non-Human Primate Kidney Transplant Model
L. Higginbotham,¹ D. Mathews,¹ C. Breeden,¹ W. Wakwe,¹ C. Larsen,¹ S. Nadler,² A. Adams.¹
¹Emory Transplant Center, Emory University School of Medicine, Atlanta; ²Bristol-Myers Squibb, Princeton.
Introduction. Costimulation blockade using belatacept has the potential to improve long-term renal function and reduce cardiovascular risk by avoiding calcineurin inhibitors, yet higher rates and…
2015 American Transplant Congress
A Novel Maintenance Regimen With Calcineurin Inhibitor, MMF and Everolimus Initiated By Dual Induction Therapy With Anti-CD20/25 Antibodies in Renal Transplantation
N. Masaki, K. Iwado, I. Nakagima, S. Fuchinoue.
Surgery III, Tokyo Women's Medical University Hospital, Shinjuku-ku,Tokyo, Japan.
【background】Calcineurin inhibitor (CNI), MMF and steroid has been the gold standard of maintenance regimen in renal transplantation (RTx). A line of new immunosuppressants has emerged…
2015 American Transplant Congress
microRNA-494 Promotes Cyclosporine-Induced Nephrotoxicity and Epithelial to Mesenchymal Transition By Inhibiting PTEN
J. Yuan,¹ C. Benway,^1,2 J. Bagley,¹ J. Iacomini.^1,2
¹Department of Developmental, Molecular and Chemical Biology, Tufts University School of Medicine, Boston, MA; ²Sackler School of Biomedical Sciences Programs in Immunology and Genetics, Tufts University School of Medicine, Boston, MA.
Purpose: A major complication associated with cyclosporine (CsA) treatment is nephrotoxicity. MicroRNAs (miRs) have been shown to play an important role in various pathological conditions,…
2015 American Transplant Congress
Evaluation of Medication Regimen Complexity Over Time Following Heart Re-Transplantation
B. Bryant,¹ A. Libby,¹ R. Page,¹ J. Lindenfeld,² C. Aquilante.¹
¹University of Colorado Skaggs School of Pharmacy and Pharmaceutical Sciences, Aurora, CO; ²University of Colorado School of Medicine, Aurora, CO.
Medication regimen complexity (MRC) includes many characteristics of a drug regimen. Previously, we showed that MRC is high and persists over time after primary heart…