ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Immunosuppression"

  • 2015 American Transplant Congress

    Explorative Analysis of ZEUS After 5 Years: Histological Assessment from Biopsy Analyses

    U. Eisenberger,1 K. Budde,1 O. Witzke,1 F. Lehner,1 C. Sommerer,1 R. Wuethrich,3 P. Reinke,1 A. Muehlfeld,1 K. Heller,1 R. Stahl,1 H. Wolters,1 I. Hauser,1 M. Porstner,2 W. Arns.1

    1ZEUS Study Group, Germany; 2Novartis, Pharma, Germany; 3ZEUS Study Group, Switzerland.

    Background: Analysis of pathologists' assessments and histological data allow for deeper insight on patient outcome together with investigator's final clinical diagnoses. Here we present 5…
  • 2015 American Transplant Congress

    Calcineurin Inhibitor-Free Immunossupresion After Kidney Transplantation, Using Everolimus De Novo – Single Center Experience

    M. Stronka, Z. Adamska, L. Cichanska, J. Kubiak, M. Gamrat, M. Karczewski.

    Department of Transplantology, General, Vascular and Plastic Surgery, Clinical Hospital of Poznan University of Medical Sciences, Poznan, Poland.

    The aim of the study was to analyse the clinical outcome in kidney transplant recipients treated with CNI (calcineurin inhibitors)-free protocol versus kidney transplant recipients…
  • 2015 American Transplant Congress

    Liver Allograft Provides Immunoprotection for the Cardiac Allograft in Combined Heart-Liver Transplantation

    T. Wong, J. Stulak, J. Heimbach, M. Stegall, T. Taner.

    Mayo Clinic, Rochester, MN.

    When transplanted simultaneously, the liver allograft has been thought to have an immunoprotective role on other organs. However, detailed studies on simultaneous heart-liver transplantation (SHLT)…
  • 2015 American Transplant Congress

    Pancreas Transplantation Immunosuppression Induction With Rabbit Antithymocyte Globulin +/- Rituximab and Early Steroid Withdrawal: Experience With >500 Recipients

    J. Fridell,1 R. Mangus,1 J. Chen,2 M. Mujtaba,3 T. Taber,3 M. Goble,1 J. Powelson.1

    1Surgery, Indiana University School of Medicine, Indianapolis, IN; 2Pharmacy, Indiana University School of Medicine, Indianapolis, IN; 3Medicine, Indiana University School of Medicine, Indianapolis, IN.

    T-cell depleting antibody induction, often combined with steroid withdrawal, has become standard practice for pancreas transplantation. In this study, outcomes of >500 pancreas transplants using…
  • 2015 American Transplant Congress

    Improved Long-Term Graft Survival in Renal Transplant Recipients With Donor Specific Antibodies (DSA) After Mycophenolic Acid Escalation

    L. Rebellato,1 K. Parker,2 F. Rana,3 S. Kendrick,4 C. Morgan,5 C. Haisch,5 M. Everly,6 R. Harland,5 P. Bolin.3

    1Pathology and Laboratory Medicine, East Carolina University, Brody School of Medicine, Greenville, NC; 2Vidant Medical Center, Greenville, NC; 3Internal Medicine, East Carolina University, Brody School of Medicine, Greenville, NC; 4Eastern Nephrology Associates, Greenville, NC; 5Surgical Immunology and Transplantation, East Carolina University, Brody School of Medicine, Greenville, NC; 6Terasaki Foundation, Los Angeles, CA.

    Background: DSA formation in post-renal transplant patients is associated with chronic rejection and graft failure. Previous studies in our population indicate DSA formation is a…
  • 2015 American Transplant Congress

    Incidence and Outcomes of Polyomavirus Infection in 639 Kidney Transplant Recipients: Are High Immunological Risk Characteristics More Relevant Than Specific Induction Or Maintenance Immunosuppressive Regimens?

    E. Favi,1 L. Harris,2 J. Worsfold,2 R. Cacciola,1 C. Puliatti,1 C. Sammartino,1 R. Sivaprakasam.1

    1Transplantation, Royal London Hospital, London, United Kingdom; 2Barts and The London School of Medicine and Dentistry, London, United Kingdom.

    Introduction. Polyomavirus-associated nephropathy (PVAN) is now recognized as an important cause of graft dysfunction and early kidney transplant loss. Over-immunosuppression is the main risk factor…
  • 2015 American Transplant Congress

    Safety and Efficacy of Early Everolimus in De Novo Orthotopic Liver Transplantation

    M. Gastaca,1 I. Bilbao,2 M. Jimenez,3 J. Bustamente,1 C. Dopazo,2 R. Gonzalez,3 R. Charco,2 J. Santoyo,4 J. Ortiz de Urbina.1

    1Liver Transplantation Unit, Cruces University Hospital. University of the Basque Country, Bilbao, Vizcaya, Spain; 2Hepatobiliopancreatic Surgery and Liver Transplant Unit, Hospital Universitario Vall d´Hebron, Barcelona, Spain; 3Unidad de Hepatología-Trasplante Hepático, Hospital Regional Universitario de Malaga, Malaga, Spain; 4Unidad de Cirugía Hepatobiliar-Trasplante Hepático, Hospital Regional Universitario de Malaga, Malaga, Spain.

    Purpose: To study the safety and efficacy of immunosuppression with Everolimus (EVL) within the first month after orthotopic liver transplantation.Patients and methods: Recipients who had…
  • 2015 American Transplant Congress

    Non-Cytoreductive Immunosuppression Prevents Rejection of Vascularized Composite Allografts

    B. Oh, G. Furtmüller, M. Fryer, G. Raimondi, D. Cooney, W. Lee, G. Brandacher.

    Department of Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, United Kingdom.

    [Background] Reconstructive transplantation represents a valid therapeutic option after devastating tissue loss such as an extremity or face. Immunosuppression-free donor-specific immunological tolerance has been successfully…
  • 2015 American Transplant Congress

    A Randomized Cross-Over Phase 3b Study of the Pharmacokinetics of Once-Daily Extended Release MeltDose® Tacrolimus (Envarsus® XR) Versus Twice-Daily Tacrolimus in African-Americans (ASERTAA)

    J. Trofe-Clark,1,2 D. Brennan,3 P. West-Thielke,4 M. Milone,5 M. Lim,2 R. Bloom.2

    1Pharmacy Services, Hospital of the University of Pennsylvania, Philadelphia; 2Renal Division, Perelman School of Medicine, University of Pennsylvania, Philadelphia; 3Renal Division, Washington University, St. Louis; 4University of Illinois at Chicago, Chicago; 5Penn Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia.

    The CYP3A5*1 genotype, highly prevalent in African Americans (AA), commonly necessitates higher tacrolimus (tac) dose requirements and may hinder efforts to obtain therapeutic drug levels.…
  • 2015 American Transplant Congress

    First Dose Tacrolimus Level Is Better Than CYP3A5 Genotyping in Prediction of Target Tacrolimus Dose

    N. Townamchai,1 W. Chancharoenthana,1 S. Wattanatorn,1 S. Vadcharavivad,2 P. Chariyavilaskul,3 A. Leelahavanichkul,4 Y. Avihingsanon,1 K. Praditpornsilpa.1

    1Department of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital, Bangkok, Thailand; 2Department of Pharmacy Practice, Chulalongkorn University, Bangkok, Thailand; 3Pharmacokinetic Research Unit, Chulalongkorn University, Bangkok, Thailand; 4Department of Microbiology, Chulalongkorn University, Bangkok, Thailand.

    Background: Tacrolimus dose highly varies among Asian kidney transplant recipients. This can be explained by variety of CYP3A5 expression. CYP3A5 genotyping is highly recommended for…
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