Articles tagged "Immunosuppression"

2022 American Transplant Congress
Pediatric Liver Transplant Factors That Influence Tacrolimus Absorption
M. Chandran¹, D. Yoeli¹, A. Sater², F. Karrer¹, M. Adams¹
¹Children's Hospital Colorado, Aurora, CO, ²University of Colorado, Aurora, CO
*Purpose: The aim of this study was to investigate the association between various pediatric recipient characteristics at time of liver transplant and FK506 absorption 6…
2022 American Transplant Congress
Impact of Respiratory Viral Panel Testing on Clinical Decision-Making Among Lung Transplant Recipients Based on Extent of Immunosuppression
A. C. Vostal¹, A. Lynen², S. Chintalapati¹, M. Uehling¹, K. Prakash², A. Shishido¹, J. Baghdadi²
¹University of Maryland Medical Center, Baltimore, MD, ²University of Maryland School of Medicine, Baltimore, MD
*Purpose: Lung transplant recipients (LTRs) are at high risk for complications from viral respiratory infection, including chronic allograft dysfunction. Thus, multiplex molecular testing for respiratory…
2022 American Transplant Congress
Longitudinal Characterization of the Microvirome in a Cohort of Renal Transplant Recipients
A. C. Johnson, G. Karadkhele, C. P. Larsen
Emory University, Atlanta, GA
*Purpose: The selective targeting of T cells in transplant immunosuppression medications leads to a high rate of viral infections, with different immunosuppression regimens resulting in…
2022 American Transplant Congress
Outcomes of a Novel Belatacept-Based Regimen – Beyond 2 Years of Follow-Up
G. Katz-Greenberg¹, J. Byrns²
¹Department of Medicine, Duke University Medical Center, Durham, NC, ²Department of Pharmacy, Duke University Medical Center, Durham, NC
*Purpose: For kidney transplant recipients (KTR) there are limited choices of immunosuppression (IS) maintenance regimens. The most commonly used regimen consists of a calcineurin inhibitor…
2022 American Transplant Congress
Early Experience with 4-drug Maintenance Immunosuppression in Kidney and Pancreas Transplant Recipients
S. Mouawad¹, C. Shoemaker², J. Geyston³, A. Nishio Lucar³
¹University of Virginia Health System, Charlottesville, VA, ²Pharmacy, UVA Health, Charlottesville, VA, ³University of Virginia, Charlottesville, VA
*Purpose: Belatacept based immunosuppression regimens in kidney transplant recipients have been associated with better kidney function, improved metabolic profile, less de novo DSA formation and…
2022 American Transplant Congress
COVID-19 Syndrome After Liver Transplant: Immunosuppression Role and Risk Factors for Mortality
M. M. Pascale¹, F. Frongillo¹, G. Bianco¹, F. Galiandro², E. Nure¹, S. Agnes¹, F. Giovinazzo¹
¹General Surgery and Liver Transplant Unit, Fondazione IRCSS - Policlinico "A. Gemelli", Roma, Italy, ²General Surgery Unit, ULSS3 Serenissima, Venezia, Italy
*Purpose: Data on mortality and immunosuppression role regarding Liver transplant recipients affected by COVID-19 are still under debate. The present study identified risk factors for…
2022 American Transplant Congress
Disruption of B Cell Population is Associated with Increased Infections in Pediatric Transplant Recipients
B. Geng, L. Loop, C. Anterasian, D. Mortazavi, J. Kitsen, C. Collins, K. Newton, E. Ingulli
Pediatrics, UCSD Rady Children's, San Diego, CA
*Purpose: Solid-organ transplant recipients are placed on long-term immunosuppression, preventing graft rejection but increasing the risk of infection. Pediatric transplant recipients are at increased risk…
2022 American Transplant Congress
Accepting Rejection in Liver Transplant Recipients Requiring Renal Replacement Therapy: A Practice Paradigm
S. Farghaly¹, T. Sparkes¹, B. Masters¹, A. Haririan², N. Jakhete³, R. N. Barth⁴, D. Maluf⁵, S. Freedman¹
¹Pharmacy, University of Maryland Medical Center, Baltimore, MD, ²Nephrology, University of Maryland Medical Center, Baltimore, MD, ³Hepatology, University of Maryland Medical Center, Baltimore, MD, ⁴Transplant Surgery, University of Chicago Medical Center, Chicago, IL, ⁵Transplant Surgery, University of Maryland Medical Center, Baltimore, MD
*Purpose: The purpose of this study is to evaluate rejection outcomes in those requiring renal replacement therapy (RRT) after liver transplant.*Methods: This was a single…
2022 American Transplant Congress
The Application of Activated Stem Cells from Human Exfoliated Deciduous Teeth (SHED) in Islet Transplantation for Novel Immunosuppressive Therapy
K. Ishiyama¹, M. Kato², S. Tsunekawa², Y. Miwa¹, K. Iwasaki¹, H. Kamiya², T. Kobayashi¹
¹Division of Kidney Transplantation, Department of Surgery, Aichi Medical University, Nagakute, Japan, ²Division of Diabetes, Department of Internal Medicine, Aichi Medical University, Nagakute, Japan
*Purpose: While various attempts have been made to improve the efficiency of islet transplantation, we have been working on the analysis of the mechanism of…
2022 American Transplant Congress
Chimeric Antigen Receptor Regulatory T Cells (CAR-Tregs) Provide Significantly Greater Modulation of Alloimmune Responses Than Alternative Alloantigen-Specific Treg Strategies
A. S. Kurt¹, P. Ruiz¹, E. Kodela¹, G. Lombardi¹, M. Martinez-Llordella², A. Sanchez-Fueyo¹
¹King's College London, London, United Kingdom, ²Quell Therapeutics, London, United Kingdom
*Purpose: Conferring alloantigen-specificity to ex vivo expanded CD4+CD25+Foxp3+ Tregs increases their capacity to counteract effector alloimmune responses following adoptive transfer into transplant recipients. This has…