Articles tagged "Immunosuppression"

2022 American Transplant Congress
Everolimus in Liver Transplantation for Diffuse, Unresectable Neuroendocrine Tumor
J. M. Vanatta¹, R. A. Helmick², C. Eymard², N. Nezakatgoo², P. Horton², J. P. Kothadia², S. P. Nair², J. D. Eason²
¹Transplantation, University of Tennessee/Methodist University Hospital, Memphis, TN, ²Transplantation, University of Tennessee, Memphis, TN
*Purpose: Liver transplantation (LT) has emerged as a therapy in selected patients for neuroendocrine tumor (NET) by providing cytoreduction. Progression-free survival in NET has been…
2022 American Transplant Congress
Single-Cell RNA Sequencing Highlights the Role of Epithelial-Immune Dual Feature of Proximal Tubule Cells in BK Virus Nephropathy
G. Huang, F. Yang, X. Chen, G. Zhao, H. Zhang, J. Luo, S. Yang, L. Zhou
Organ Transplant Center, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China
*Purpose: BK virus nephropathy (BKVN) may cause renal allograft dysfunction and failure. However, a specific antiviral agent for BK virus does not exist. Increasing evidence…
2022 American Transplant Congress
Clinical Stratification of Pediatric Liver Transplant Recipients 4-5 Years Post-Transplant: 1^St Step Towards Personalized Management
W. Dixon¹, E. R. Perito¹, M. Tavakol¹, J. Bucuvalas², S. Feng¹
¹University of California, San Francisco, San Francisco, CA, ²Mount Sinai Kravis Children's Hospital and Recanati/Miller Transplantation Institute, Mount Sinai Health System, New York, NY
*Purpose: Recent surveillance biopsy studies strongly associate high normal ALT (>35U/L) with inflammatory histopathology and low normal ALT (15yrs (n=13; p=0.0006), chronic rejection (CR) diagnosis…
2022 American Transplant Congress
Adoptive Transfer OfMesenchymal Stem Cells Activates Hedgehog/SMO/Gli1 Signaling And Inhibits STING-mediated Innate Immune Response In Liver Transplant Inflammatory Injury
D. Xu¹, X. Qu¹, Y. Tian¹, M. Sheng¹, Y. Lin¹, Y. Zhan¹, F. M. Kaldas¹, R. W. Busuttil¹, D. G. Farmer¹, J. W. Kupiec-Weglinski¹, Q. Xia², B. Ke¹
¹Surgery, Dumont - UCLA Transplant Ctr, Los Angeles, CA, ²Liver Surgery, Shanghai Jiaotong University School of Medicine, Shanghai, China
*Purpose: The stimulator of interferon genes (STING) pathway has been recognized as a crucial signaling cascade of the innate immune system. Activation of the Hedgehog…
2022 American Transplant Congress
Outcomes of Primary Simultaneous Pancreas-Kidney Transplants by Induction Agent in the United States
A. Cerise¹, T. Shaker¹, K. Ramanathan¹, S. Jackson², R. Kandaswamy¹, S. Riad³
¹Surgery, University of Minnesota, Minneapolis, MN, ²Analytics, MHealth-Fairview, Minneapolis, MN, ³Medicine, University of Minnesota, Minneapolis, MN
*Purpose: Induction immunosuppression choice for simultaneous pancreas-kidney (SPK) transplants varies widely in the United States. We examined the association between induction agents and outcomes of…
2022 American Transplant Congress
Evaluating the Risk and Benefit of Once Daily Delayed Release Mycophenolate in Pediatric Kidney Transplant Recipients
L. Maestretti¹, A. McGrath¹, A. Fong¹, A. Brubaker², A. Gallo³, P. Grimm³, A. Chaudhuri³
¹Pediatric Kidney Transplant, Stanford Children's Health, Palo Alto, CA, ²Transplant Surgery, Stanford University, Palo Alto, CA, ³Stanford University, Palo Alto, CA
*Purpose: Medication non-adherence continues to particularly affect adolescent kidney transplant recipients. Standard immunosuppressive regimen at our center includes tacrolimus, and mycophenolate with or without steroids.…
2022 American Transplant Congress
Outcomes of Very Small Pediatric Donor Kidneys Utilizing Belatacept-Based Immunosuppression in Adult Recipients
K. Heinen¹, A. Carlson², A. Chan¹, M. M. Eiting¹, T. Larson¹, B. Sirandas¹, C. Truax¹, L. Smith¹
¹University of Utah Health, Salt Lake City, UT, ²Medical University of South Carolina, Johnston, SC
*Purpose: Due to the lack of data utilizing belatacept as primary immunosuppression for adult recipients of very small pediatric donor kidneys, this study seeks to…
2022 American Transplant Congress
Serological Response To Three, Four And Five Doses Of Sars-cov-2 Vaccine In Kidney Transplant Recipients
S. Ronicke¹, B. Osmanodja¹, K. Budde¹, A. Jens¹, C. Hammett¹, K. Nadine¹, J. Waiser¹, B. Zukunft¹, F. Bachmann¹, M. Choi¹, W. Ulrike¹, B. Eberspächer², J. Hofmann², F. Grunow¹, M. Mikhailov¹, L. Liefeldt¹, K. Eckardt¹, F. Halleck¹, E. Schrezenmeier¹
¹Department of Nephrology and Medical Intensive Care, Charité – Universitätsmedizin Berlin, Berlin, Germany, ²Labor Berlin - Charité Vivantes GmbH, Berlin, Germany
*Purpose: Mortality from COVID-19 among kidney transplant recipients (KTR) is unacceptably high, and their response to up to three vaccinations against SARS-CoV-2 is strongly impaired.…
2022 American Transplant Congress
An Interim Report on a Prospective Randomized Trial of Extended-Release Tacrolimus in Liver Transplantation with Anti-Thymocyte Induction in a Steroid Free Protocol
R. A. Helmick, S. Naik, C. Eymard, J. Eason, J. Vanatta
James D. Eason Transplant Institute at Methodist University Hospital and University of Tennessee Health Science Center, Memphis, TN
*Purpose: Our study hypothesis was that once daily dosing of extended-release tacrolimus (ERT) would be a safe and effective immunosuppression (IS) with the potential to…
2022 American Transplant Congress
Comparing Infection Rate Between Steroid Withdrawal and Ongoing Maintenance Among Simultaneous Pancreas-Kidney Transplant Recipients
M. McCord¹, Z. Yetmar², A. Lemke¹, K. Mara³, M. T. Seville⁴, W. Bosch⁵, P. Dean⁶, E. Beam², S. Bernard¹
¹Department of Pharmacy, Mayo Clinic, Rochester, MN, ²Division of Infectious Diseases, Mayo Clinic, Rochester, MN, ³Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN, ⁴Division of Infectious Diseases, Mayo Clinic Arizona, Scottsdale, AZ, ⁵Division of Infectious Diseases, Mayo Clinic, Jacksonville, FL, ⁶Division of Transplantation Surgery, Mayo Clinic, Rochester, MN
*Purpose: Compare infection rates of simultaneous pancreas-kidney transplant (SPK) recipients who continue maintenance steroids to those with steroid withdrawal post transplant.*Methods: This study is a…