2015 American Transplant Congress
Pharmacokinetics of Tacrolimus (TAC) in Elderly Compared to Young Recipients in the First Year After Renal Transplantation. Data from the NEverOLd Trial
Elderly (≥60years) recipients are nowadays receiving renal transplants more frequently. The pharmacokinetics studies (PK) of immunosuppressive drugs in healthy volunteers, rarely, if ever, include old…2015 American Transplant Congress
Outcomes of Kidney Transplant Recipients Minimally Immunosuppressed: A Cohort Study Analysis
Background: Renal transplantation is the treatment of choice for endstage renal disease. Nevertheless, it involves immunosuppressive treatments with Serious Adverse Events (SAE) such as infections…2015 American Transplant Congress
No Significant Outcome Benefit for Brand-Name Versus Generic Tacrolimus in Kidney Transplant Recipients: SRTR Analysis
IntroGeneric formulations of tacrolimus have been available for maintenance immunosuppression since 2009. Our aim was to evaluate the frequency of use of generic tacrolimus and…2015 American Transplant Congress
Significant Association Between Foxp3 Gene Polymorphism and Outcomes in HBV-Related Liver Transplant Patients
Gastroenterological and Transplant Surgery, Hiroshima University, Hiroshima, Japan.
Background: Previous studies have demonstrated that CD4+Foxp3+ regulatory T (Treg) cells regulate HBV-related disease progression. The present study investigated the association between Treg cells and…2015 American Transplant Congress
Analysis of In-Vitro Effects of Immunosuppression on NK Cell Subsets in the Presence of Cytomegalovirus
Background: NK cells may play an important role in the control of CMV replication post-transplant. NK cells can be divided into subsets based on surface…2015 American Transplant Congress
Renal Dysfunction by BK Virus Infection Is Correlated With Activated T Cell Level, Cytokines Level, Gramzymes in Renal Transplantation
Purpose:BK virus (BKV) is known to be associated with nephropathy (BKAN). Here, we investigated the relationships between BKV levels, T-cell activation, cytokines and kidney function…2015 American Transplant Congress
Plasmapharesis, Intravenous Immunoglobulin and Rituximab Successfully Treat Recurrent Progressive Familial Intrahepatic Cholestasis Type 2 (PFIC-2) After Liver Transplantation
Background:Allo-immune mediated BSEP dysfunction may occur after liver transplantation in PFIC2 patients leading to a PFIC2 like phenotype. The IgG antibodies are reactive toward a…2015 American Transplant Congress
Glycogen Synthase Kinase 3β Inhibition Promotes Human iTreg Differentiation and Suppressive Function
The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Induced regulatory T cells (iTregs) are essential to maintain immunological tolerance, immune homeostasis, and prevention of autoimmunity. Some studies suggest that glycogen synthase kinase 3β…2015 American Transplant Congress
Improved Bioavailability and Reduced Dose Requirements of Novel, Once-Daily, MeltDose® Tacrolimus Formulation Tablets (Envarsus® XR) Compared to Twice-Daily Tacrolimus Capsules (Prograf®) in De Novo Kidney Transplantation: Results of a Phase 3 Double-Dummy, Randomized Trial
Tacrolimus (tac) is an immunosuppressive drug with a narrow therapeutic range. Adequate trough levels following kidney transplantation (≥6 ng/mL depending on regimen and time post-transplant)…2015 American Transplant Congress
ABCB1 Haplotypes, Sex, Calcineurin Inhibitors and Lipid Profiles Post-Renal Transplant
Purpose: Hyperlipidemia is common in renal transplant recipients (RTR) during calcineurin inhibitor (CNI) immunosuppression. P-glycoprotein (P-gp) is an efflux transporter encoded by ABCB1 that modulates…
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