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Articles tagged "Immunosuppression"

  • 2015 American Transplant Congress

    Immunosuppression and Reoperation After Simultaneous Kidney Pancreas Transplantation Convey Greatest Risk for Rejection

    C. Bratton, V. Rohan, S. Nadig, J. Mcgillicuddy, K. Chavin, P. Baliga, D. Taber.

    MUSC, Charleston, SC.

    Background: Episodes of acute cellular rejection (ACR) convey significant morbidity after simultaneous kidney and pancreas transplantation (SPK). The role of recipient sensitization, immunosuppression (IS) and…
  • 2015 American Transplant Congress

    Characterization of Peripheral Blood T and B Cells of Sensitized Kidney Transplant Recipients With Long Term Stable Graft Function

    N. Galante,1 M. Fernandes,1 F. Agena,1 A. Triboni,1 G. Freitas,1 A. Aguirre,1 W. Nahas,1 V. Coelho,2 E. David-Neto.1

    1Renal Transplant Service, Hospital das Clínicas - University of Sao Paulo School of Medicine, Sao Paulo, Brazil; 2Laboratory of Immunology, Heart Institute - University of Sao Paulo School of Medicine, Sao Paulo, Brazil.

    We examined the phenotype of T and B cells of peripheral blood of sensitized kidney transplant recipients with stable graft function (GFR > 29mL/min) enrolled…
  • 2015 American Transplant Congress

    Once Daily Dosing Is as Effective as Twice Daily Dosing of Immediate Release Tacrolimus

    L. Bowman,1 T. Horwedel,1 J. Hagopian,1 B. Bone,2 H. Wijeweera,2 D. Brennan.2

    1Barnes-Jewish Hospital, St. Louis; 2Washington University School of Medicine, St. Louis.

    Purpose: Extended release (ER) tacrolimus (tac) has been available as Advagraf® for many years and as Astagraf XL® in the US since 2013. Immediate release…
  • 2015 American Transplant Congress

    Post Hoc Subgroup Analysis of ZEUS: Outcome on Renal Function, Efficacy and Safety in Living-Donor Kidney Transplant Recipients After Conversion from a Calcineurin Inhibitor to an Everolimus Based Regimen: 5 Year Follow-Up Data

    F. Lehner,1 K. Budde,1 R. Wuethrich,2 P. Reinke,1 W. Arns,1 A. Muehlfeld,1 U. Eisenberger,1 R. Stahl,1 K. Heller,1 O. Witzke,1 B. Suwelack,1 H. Wolters,1 I. Hauser,1 M. Porstner,3 C. Sommerer.1

    1ZEUS Study Group, Germany; 2ZEUS Study Group, Switzerland; 3Novartis, Pharma, Germany.

    Background: To study renal function and patient outcome after 5 years in living donation subgroup of kidney de novo transplant recipients after conversion to an…
  • 2015 American Transplant Congress

    Generation, Cryopreservation, Function and In Vivo Fate of Ex-Vivo Expanded Cynomolgus

    H. Guo,1 H. Zhang,1 L. Lu,1 M. Ezzelarab,1 A. Thomson.1,2

    1Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA; 2Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA.

    Background:Foxp3+ regulatory T cells (Treg) function to promote immune tolerance and prevent immunopathogenesis. Preclinical studies have demonstrated that adoptive transfer of Treg prevents rejection of…
  • 2015 American Transplant Congress

    An Economic Analysis of Tolerance Induction for Two-Haplotype Match Kidney Living Donor Transplant Recipients

    K. Erickson,1 W. Winkelmayer,2 R. Lowsky,1 J. Scandling,1 S. Strober.1

    1Medicine, Stanford University, Palo Alto, CA; 2Medicine, Baylor College of Medicine, Houston, TX.

    Purpose:Tolerance induction is a novel therapy that enables some living donor kidney transplant recipients (LDKTR) to safely discontinue immunosuppressive (IS) therapy. We examine whether tolerance…
  • 2015 American Transplant Congress

    Rabbit Antithymocyte Globulin Is Associated With Improved Patient and Graft Survival in Liver Transplantation. Experience With 595 Patients

    M. Montenovo,1 F. Jalikis,2 L. Meng,3 Y. Matthew,2 D. Andre,1 H. Ryan,3 R. Jorge.1

    1Surgery, University of Washington, Seattle, WA; 2Pathology, University of Washington, Seattle, WA; 3Pharmacy, University of Washington, Seattle, WA.

    BACKGROUND: Use of induction therapy in liver transplantation is debatable. We aimed to compare clinical outcomes of different induction protocols in liver transplant recipients.METHODS: Retrospective…
  • 2015 American Transplant Congress

    Thymoglobulin Administration During Multi-Visceral and Isolated Small Bowel Procurement Does Not Adversely Affect the Survival of Harvested Organs

    G. Jain, T. Burnett, J. Preheim, L. Vargas, W. Grant, A. Langnas, D. Mercer, G. Jain.

    Division of Transplantation, Department of Surgery, University of Nebraska Medical Center, Omaha, NE.

    Anti-thymocyte globulin administration in donors before intestinal procurement may result in decreased graft versus-host disease (GVHD) due to reduced recipient lymphocyte trafficking after reperfusion. Reluctance…
  • 2015 American Transplant Congress

    Incidence and Risk Factors for Infectious Complications in Liver Transplant Patients Converted to Everolimus

    A. Islam,1 J. DeVos,2 L. Teeter,3 E. Graviss,3 S. Gordon-Burroughs,1 A. Saharia,1 C. Mobley,1 A. Gaber,1 R. Ghobrial.1

    1Department of Surgery, Houston Methodist Hospital, Houston, TX; 2Department of Pharmacy, Houston Methodist Hospital, Houston, TX; 3Department of Pathology & Genomic Medicine, Houston Methodist Hospital, Houston, TX.

    AIM:Immunosuppression with an mTOR inhibitor plus calcineurin inhibitor (CNI) minimization is increasingly used in liver transplantation to protect against the nephrotoxic and neurotoxic side effects…
  • 2015 American Transplant Congress

    Current Status of US Intestinal and Multivisceral Transplantation: An Analysis of the UNOS Intestine Transplant Registry

    J. Cai,1 A. Qing,2 G. Wu,3 M. Everly,1 P. Terasaki.1

    1Terasaki Foundation Lab, Los Angeles, CA; 2Lincoln High School, Stockton, CA; 3The 4th Military Medical University, Xi-An, China.

    The purpose of this study is to analyze the current status of US intestinal transplantation (IT). As of 9/19/2014, 2441 IT have been performed in…
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