Articles tagged "Immunosuppression"

2016 American Transplant Congress
Evaluation of the Major Adverse Cardiac Events Risk with Everolimus-Based Calcineurin Inhibitor Reduction or Withdrawal Regimen in Liver Transplant Recipients: 3-Year Post-Hoc Analysis of the Randomized H2304 Extension Study.
P. Bernhardt,¹ G. Dong,² P. Lopez,¹ G. Hustache,¹ G. Bader.¹
¹Novartis Pharma AG, Basel, Switzerland; ²Novartis Pharmaceuticals Corporation, East Hannover.
Purpose:Cardiovascular disease (CVD) is one of the leading causes of death in liver transplant recipients (LTxRs). Impaired glomerular filtration rate (GFR) is a risk factor…
2016 American Transplant Congress
2B4 Over-Expression Impairs Donor-Reactive CD8+ T Cell Proliferation and Accumulation Following Transplantation.
S. Laurie, D. Liu, M. Ford.
Emory Transplant Center, Emory University School of Medicine, Atlanta, GA.
T cell function is tightly regulated by a fine balance of coinhibitory signals, including those transduced by 2B4 (SLAMf4, CD244), an immunoglobulin-superfamily member constitutively expressed…
2016 American Transplant Congress
Antithymocyte Globulin (ATG) versus Anti-interleukin-2 Receptor (Anti-IL-2R) as Induction Therapy for Kidney Transplantation After a Nonrenal Transplant.
H. Mai,¹ K. Trébern-Launay,¹ C. Legendre,² M. Kessler,³ L. Rostaing,⁴ V. Garrigue,⁵ E. Morelon,⁶ S. Brouard,¹ M. Giral,¹ J.-P. Soulillou.¹
¹Service de Néphrologie et Transplantation, INSERM UMR 1064, CHU de Nantes, Nantes, France; ²Hôpital Necker, Paris, France; ³CHU de Nancy, Nancy, France; ⁴CHU de Toulouse, Toulouse, France; ⁵CHU de Montpellier, Montpellier, France; ⁶CHU de Lyon, Lyon, France.
Patients undergoing kidney transplant after a previous nonrenal organ transplant (NRT) present a small but emerging subpopulation of kidney transplant recipients. Little is known about…
2016 American Transplant Congress
Everolimus/Low Tacrolimus(TAC) Compared to MPA/RegularTAC for Renal Transplantation in the Elderly Recipient – Preliminary Analysis of the nEverOld Trial.
E. David-Neto,¹ F. Agena,¹ F. Ramos,¹ A. Triboni,¹ M. Altona,² V. Coelho,² N. Galante,¹ F. Lemos.¹
¹Kidney Transplant Service, Hospital das Clínicas, University of São Paulo School of Medicine, Sao Paulo, Brazil; ²Geriatric Service, Hospital das Clínicas, University of São Paulo School of Medicine, Sao Paulo, Brazil.
In the last decade, elderly patients (≥60y) have been more frequently listed for renal transplantation. From 2007 to 2014 the percentage of elderly renal transplant…
2016 American Transplant Congress
Hepatitis C Patients in a Multicenter Study Who Received Living Donor Liver Transplants Are Likely to Have Increased Survival.
J. Kim,¹ K.-W. Lee,² G.-W. Song,³ B.-H. Jung,³ H. Lee,⁴ N.-J. Yi,² C. Kwon,¹ S. Hwang,³ K.-S. Suh,² J.-W. Joh,¹ S.-K. Lee,¹ S.-G. Lee.³
¹Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea; ²Department of Surgery, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea; ³Division of Hepatobiliary Surgery and Liver Transplantation, Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea; ⁴Department of Surgery, Seoul National University Boramae Medical Center, Seoul, Korea.
Background: No consensus has been reached regarding comparisons of outcomes for patients with hepatitis C virus (HCV) who received living donor liver transplantation (LDLT) versus…
2016 American Transplant Congress
Porcine Islets Engineered with SA-FasL Protein Induces Robust Tolerance in Mice through CD4⁺CD25⁺FoxP3⁺ Treg Cells.
K. Woodward,¹ H. Zhao,¹ H. Shirwan,¹ F. Wang,¹ M. Graham,² B. Hering,² E. Yolcu.¹
¹Institute for Cellular Therapeutics and Department of Microbiology and Immunology, University of Louisville, Louisville, KY; ²Schulze Diabetes Institute and Department of Surgery, University of Minnesota, Minneapolis, MN.
Introduction: We have shown that porcine islets engineered to transiently display SA-FasL protein on their surface establish tolerance in mice following transplantation under the kidney…
2016 American Transplant Congress
Elderly Kidney Transplant Recipients Need Optimized Immunosuppression According to Comorbidity and Infection.
E. Kang,¹ S. Park,¹ S. Park,¹ S. Yang,² I. Jung,³ S.-K. Park,⁴ Y. Kim,⁵ D.-J. Han,¹ Y. Kim,¹ J. Lee.⁶
¹Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea; ²Kidney Research Institute, Seoul National University College of Medicine, Seoul, Korea; ³Department of Surgery, Seoul National University Boramae Medical Center, Seoul, Korea; ⁴Department of Internal Medicine, Asan Medical Center and University of Ulsan College of Medicine, Seoul, Korea; ⁵Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea; ⁶Department of Internal Medicine, Seoul National University Boramae Medical Center, Seoul, Korea.
Backgrounds: The numbers of elderly kidney transplantation is increasing, but there are limited studies about the use of immunosuppressant in this group. We investigated the…
2016 American Transplant Congress
Rare Presentation of PTLD as Parotitis.
R. Pullalarevu, A. Posadas Salas, G. Mour, T. Srinivas, N. Salazar, P. Mohan.
Medicine, MUSC, Charleston, SC.
28y/o AAF w/ hx of CAH, HTN, and ESRD, was on HD for 3 yrs. Pt was EBV seronegative prior to transplant (tx). She received…
2016 American Transplant Congress
Kinetics of Cytomegalovirus Load in Kidney Transplant Recipients Receiving Everolimus or Mycophenolate Sodium and No Pharmacological Prophylaxis.
G. Basso, C. Felipe, A. Ferreira, M. Cristelli, N. Oliveira, T. Sandes-Freitas, J. Mansur, L. Viana, W. Aguiar, E. Campos, M. Gerbasi-DeLima, H. Tedesco-Silva, J. Medina-Pestana.
Hospital do Rim, São Paulo, Brazil.
The purpose of this analysis is to investigate the kinetics of cytomegalovirus (CMV) viral load in kidney transplant recipients receiving tacrolimus (TAC) plus everolimus (EVR)…
2016 American Transplant Congress
Belatacept Conversion in Adult Kidney Transplant Recipients for Cause: A Single Center Observational Cohort.
M. Savic,¹ M. Cruz,² A. Rossi,¹ J. Vella.¹
¹Maine Transplant Program, Maine Medical Center, Portland, ME; ²University of Connecticut, Storrs, CT.
Background: Calcineurin inhibition (CNI) is the single most effective strategy to prevent allograft rejection however tolerability is limited by toxicity. To date, alternate strategies have…