Articles tagged "Immunosuppression"

2016 American Transplant Congress
Preimplantation and Post-Transplant Serial Biopsies of Standard and Extended Criteria Donor Kidneys: Intragraft Molecular Profiles and Effect of Different Immunosuppressive Protocols.
C. Mazeti,¹ H. Caldas,¹ I. Fernandes-Charpiot,² M. Baptista,² M. Abbud-Filho.^1,2,3
¹Laboratory of Immunology and Experimental Transplantation, Medical School, Sao Jose do Rio Preto, SP, Brazil; ²Department of Medicine/Nephrology, Medical School, Sao Jose do Rio Preto, SP, Brazil; ³Urology and Nephrology Institute, Urology and Nephrology Institute, Sao Jose do Rio Preto, SP, Brazil.
Background: Use of extended criteria donor kidneys (ECD) carries the fear of to transplant of inferior quality and therefore of high discard rate. Clinical tools…
2016 American Transplant Congress
Pneumocystis Pneumonia Following Solid Organ Transplantation, Systematic Review and Meta-Analysis.
S. Hosseini-Moghaddam,^1,2 R. Krishnan.²
¹Medicine, Western University, London, ON, Canada; ²Epidemiology and Biostatistics, Western University, London, ON, Canada.
Background: Different variables have been reported that may increase the risk of pneumocystis pneumonia (PCP) in solid organ transplant patients (SOT).Objectives:To investigate the effect of…
2016 American Transplant Congress
Quality Improvement Initiative to Provide Comprehensive Pharmacy Services to Kidney Transplant Patients at a Small Transplant Center.
J. Dickson,¹ W. Vincent III,¹ L. Wu,² J. Thurman,¹ J. Francis,³ M. Nuhn.⁴
¹Pharmacy, Boston Medical Center, Boston, MA; ²Northeastern University, Boston, MA; ³Renal Medicine, Boston Medical Center, Boston, MA; ⁴Transplant Surgery, Boston Medical Center, Boston, MA.
Purpose: Previously, kidney transplant pharmacy services at our institution were limited to medication profile review before and after transplant surgery. Following an OPTN accreditation site…
2016 American Transplant Congress
Conditional Long Term Intestine Patient and Graft Survival Is Improving Under rATG Immunosuppression in Pediatric Intestine Transplantation.
N. Celik,¹ F. Vyas,¹ G. Bond,¹ K. Soltys,¹ J. Rudolph,² R. Sindhi,¹ G. Mazariegos.¹
¹Hillman Center for Pediatric Transplantation, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA; ²Intestinal Care and Rehabilitation Center, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA.
Aim: We reviewed conditional graft survival and short and long term improvements in children receiving rATG (rabbit anti-thymocyte globulin) immunosuppression for intestine transplantation at a…
2016 American Transplant Congress
Foxp3 Controls Oxidative Phosphorylation in Regulatory T Cells.
U. Beier,¹ A. Angelin,² J. Jiao,¹ H. Xiao,¹ L. Wang,³ S. Dahiya,³ A. Wells,³ D. Wallace,² W. Hancock.³
¹Pediatric Nephrology, Children's Hospital of Philadelphia and University of Pennsylvania, Philadelphia, PA; ²Center for Mitochondrial and Epigenomic Medicine, Children's Hospital of Philadelphia, Philadelphia, PA; ³Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia and University of Pennsylvania, Philadelphia, PA.
Current immunosuppressive therapies are limited by non-specificity and toxicities, and new pharmacologic approaches to immunosuppressive therapies are needed. Many T cell subsets have distinct metabolic…
2016 American Transplant Congress
Pre-Transplant IgM to Post-Transplant IgG DSA Conversion May Be Affected by Immunosuppression.
A. Nguyen,¹ M. Everly,¹ L. Rebellato,² C. Haisch,² K. Briley,² P. Bolin,² S. Kendrick,² C. Morgan,² A. Maldonado,² P. Terasaki.¹
¹Terasaki Foundation Laboratory, Los Angeles, CA; ²East Carolina University, Greenville, NC.
Post-transplant (tx) IgG donor-specific antibodies (DSA), but not IgM DSA has been identified as one of the major causes of late graft loss. Considering the…
2016 American Transplant Congress
Establishing the Relationship Between Receptor Occupancy, Serum Exposure and Pathway Inhibition by the Blocking, Non-Depleting Anti-CD40 Antibody CFZ533 to Inform Dose Selection in Clinical Transplantation.
P. Espie, J. Munz, T. Flandre, B. Haraldsson, P. Ulrich, J. Rush.
Novartis Institutes for Biomedical Research, Basel, Switzerland.
Background. CD40-CD154 pathway blockade significantly prolongs renal allograft survival in non-human primates (NHPs), and trials of the novel blocking, non-depleting anti-CD40 monoclonal antibody (mAb) CFZ533…
2016 American Transplant Congress
CoCl2 Induced ER Stress Protein Mediated Cytotoxicity in FK506 Treated Hepatoma HepG2 Cells.
S. Choi, S. Chung.
Surgery, Chonnam National University Hospital, Gwangju, Republic of Korea; Surgery, Chonnam National University Hospital, Gwangju, Republic of Korea.
Background; The effects of FK506 on the endoplasmic reticulum (ER) mediated stress pathway accelerates CoCl2 - induced cytotoxicity in human hepatoma HepG2 cell line were…
2016 American Transplant Congress
Comparison of Once-Daily and Twice-Daily Low-Dose Tacrolimus in Living Related Kidney Transplantation – Prospective Trial of Once-Daily vs. Twice-Daily Tac – 5 Years Second Report.
T. Tsuchiya, H. Ishida, T. Nozaki, H. Shirakawa, T. Shimizu, K. Omoto, M. Okumi, K. Tanabe.
Department of Urology, Tokyo Women's Medical University, Tokyo, Japan.
Background; Previously, we reported a comparison of the safety and pharmacokinetics between a prolonged-release formulation of Tacrolimus (Tac-QD) and twice-daily tacrolimus (Tac-BD) in the early…
2016 American Transplant Congress
Significant Pharmacokinetic Interaction Between Everolimus and Tacrolimus in De Novo Renal Transplant Recipients.
H.-P. Chang,¹ C.-Y. Lee,² C.-C. Si,¹ M.-K. Tsai,² F.-L. Lin Wu.^1,3
¹Graduate Institute of Clinical Pharmacy, National Taiwan University, College of Medicine, Taipei, Taiwan; ²Surgery, National Taiwan University Hospital, College of Medicine, Taipei, Taiwan.
Studies on the effect of everolimus on tacrolimus pharmacokinetics (PK) were limited and the results were inconsistent. In contrast, studies showed there was little effect…