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American Transplant Congress abstracts

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Articles tagged "Immunosuppression"

  • 2016 American Transplant Congress

    Modification of DC Phenotype and Function via Targeted Porous Silicon Nanoparticles.

    S. Stead,1 S. McInnes,2 S. Kireta,3 P. Rose,1 D. Rojas-Canales,3 S. Jesudason,3 S. Grey,4 R. Carroll,3 N. Voelcker,2 P. Coates.1,3

    1School of Medicine, University of Adelaide, Adelaide, Australia; 2Future Industries Institute, University of South Australia, Adelaide, Australia; 3CNARTS, Royal Adelaide Hospital, Adealide, Australia; 4Transplantation Immunology, Garvan Institute of Medical Research, Sydney, Australia.

    Aims: Dendritic cells (DC) are the most potent antigen-presenting cell and are fundamental in the establishment of transplant tolerance. Targeting DC via the DC-SIGN receptor…
  • 2016 American Transplant Congress

    Effect of Complement Inhibition Therapy (Eculizumab) in Patients with C1q-Binding Donor-Specific Anti-HLA Antibodies: A Molecular Appraisal.

    C. Lefaucheur,1 L. Hidalgo,2 J. Reeve,2 D. Viglietti,1 C. Gosset,1 O. Aubert,3 C. Ulloa,3 C. Legendre,3 D. Glotz,1 P. Halloran,2 A. Loupy.3

    1Saint-Louis Hospital, Paris, France; 2University of Alberta, Edmonton, Canada; 3Necker Hospital, Paris, France.

    Complement-binding anti-HLA DSA have demonstrated higher rejection rate and decreased allograft outcome. We investigated the effect of terminal complement inhibition (Eculizumab) in a cohort of…
  • 2016 American Transplant Congress

    Comparison of Pharmacokinetic and Clinical Outcomes of Tacrolimus Hexal® with Prograf® Based Regimen in De Novo Kidney Transplant Recipients: Results from the Randomized, SparTacus Study.

    W. Arns,1 A. Huppertz,1 T. Rath,1 S. Ziefle,1 L. Rump,1 A. Hansen,1 D. Baeumer,2 K. Budde,1 L. Lehner,1 T. Klein,1 P. Schenker.1

    1SparTacus Study Group, Cologne, Germany; 2Novartis Pharma GmbH, Nuernberg, Germany.

    Background: There is very limited evidence on the pharmacokinetic (PK) and clinical outcomes, comparing a generic tacrolimus with the standard reference drug in transplant (Tx)…
  • 2016 American Transplant Congress

    Impact on Wound Healing Events After Early Conversion to Everolimus in De Novo Renal Transplant Recipients: 24-Month Results from the Randomized ELEVATE Study.

    B. Nashan,1 M. van der Giet,1 H. Holdaas,1 M. Zeier,1 J. Pascual,1 Y. Avihingsanon,1 P. Lopez,2 J. Aguilar-Sanchez,2 J. Kochuparampil,2 Z. Wang,3 J. Cruzado,1 J. De Fijter.1

    1ELEVATE Study Group, Hamburg, Germany; 2Novartis, Basel, Switzerland; 3Novartis Pharmaceutical Corporation, East Hanover.

    BackgroundWound healing events (WHE) are probably the most common type of post-transplant (Tx) surgical complication. Due to its antiproliferative properties, mammalian target of rapamycin inhibitors…
  • 2016 American Transplant Congress

    Do We Need an Individually Tailored Immunosuppression Strategy for Living Donor Kidney Transplant Recipients with PreTransplant Donor Specific Antibodies? A Retrospective Analysis.

    S. Bhutani,1 A. Ponnusamy,2 Q. Tak,1 S. Shah,1 J. Worthington,1 A. Summers,1 K. Poulton,1 D. Van Dellen,1 M. Morton,1 M. Picton.1

    1Department of Renal & Transplant Medicine, Manchester Royal Infirmary, Manchester, United Kingdom; 2Department of Renal Medicine, Royal Hospital Preston, Preston, United Kingdom.

    Introduction:Pre-Transplant Microbead donor HLA specific antibody(DSA) positive but cell crossmatch negative transplants are considered to be at increased immunological risk. This study aimed to address…
  • 2016 American Transplant Congress

    Treatment of Late Antibody-Mediated Rejection: Observations from Clinical Practice.

    G. Einecke,1 J. Bräsen,2 A. Schwarz,1 H. Haller,1 F. Njau.1

    1Nephrology, Medical School of Hannover, Hannover, Germany; 2Pathology, Medical School of Hannover, Hannover, Germany.

    Antibody-mediated rejection (AMR) is a major cause of late renal allograft failure. The benefit of treatment of chronic ABMR is unknown. Currently there is no…
  • 2016 American Transplant Congress

    Role of Preformed IgM Donor Human Leucocyte Antigen (HLA) Specific Antibodies in HLA Incompatible Renal Transplantation.

    A. Andreou, A. Babu, T. Barber, R. Higgins, D. Briggs, D. Mitchell, N. Khovanova, T. Shaikhina, S. Daga.

    Renal, University Hospitals Coventry and Wawickshire, Coventry, United Kingdom; Life Sciences, University of Warwick, Coventry, United Kingdom; School of Mathematics and Engineering, University of Warwick, Coventry, United Kingdom.

    Introduction: Pre-transplant IgG antibody screening is common due to its established role of predicting rejection and graft survival; the role of pre-formed IgM human leukocyte…
  • 2016 American Transplant Congress

    Donor-Specific Antibodies in a Single-Center Pediatric Kidney Transplant Population – Incidence and Risk Factors.

    M. Bock,1 L. Starkey,1 C. Buchanan,2 E. Steinberg,2 A. Sikora,2 K. McKinnon,2 M. Wachs,2 J. Goebel.1

    1Transplant Surgery, Children's Hospital Colorado, Aurora, CO; 2Pediatric Nephrology, Children's Hospital Colorado, Aurora, CO.

    In mid-2015, we implemented donor-specific antibody (DSA) monitoring in our pediatric kidney transplant recipient (pKTR) population as recommended (Transplantation 2013;95:19-). We now cross-sectionally analyzed our…
  • 2016 American Transplant Congress

    Tacrolimus Levels in Patients Treated with Direct Acting Antivirals Post-Transplant.

    J. Wiegel, T. Egbuka.

    Pharmacy, Oregon Health & Science University, Portland, OR.

    Purpose: To determine if treatment of recurrent hepatitis C virus (HCV) post-liver transplant with the direct-acting antivirals (DAAs) sofosbuvir, simeprevir, and ledipasvir (in combination and/or…
  • 2016 American Transplant Congress

    P-Glycoprotein Function: Association with Race, Gender and Tacrolimus Pharmacokinetics.

    K. Tornatore,1,4 H. Minderman,2 K. Attwood,3 K. O'Loughlin,2 R. Venuto.4

    1Translational Pharmacology Research, School of Pharmacy, Buffalo; 2Flow Cytometry Laboratory, Roswell Park Cancer Institute, Buffalo; 3Biostatistics, School of Public Health, Buffalo; 4Medicine, School of Medicine;UB, Buffalo.

    Background: Long term allograft survival remains poorer in African American(AA) renal transplant recipients(RTR) compared to Caucasians(C) and may be due to racial differences in calcineurin…
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