Articles tagged "Immunoglobulins (Ig)"

2021 American Transplant Congress
Outcomes of IVIG Monotherapy for Donor-Specific Antibodies After Lung Transplantation
K. Spence, S. Heeney, M. Morrison, S. A. Rega, F. D. Irene, K. B. Harrison, C. M. Shaver
Vanderbilt University Medical Center, Nashville, TN
*Purpose: De novo donor-specific antibodies (DSA) are a risk factor for antibody mediated rejection (AMR) and poor clinical outcomes after lung transplant (LT). Intravenous immune…
2021 American Transplant Congress
The Role of Notch2 in Antibody-mediated Alloimmune Response
R. Benedetti Gassen¹, N. Murakami², T. J Borges¹, A. Al Jurdi¹, A. Alessandrini¹, L. V Riella¹
¹Center of Transplantation Science, Massachusetts General Hospital, Boston, MA, ²Brigham and Women's Hospital, Boston, MA
*Purpose: Antibody mediated rejection is the leading cause of chronic allograft rejection. Developing a novel therapeutic target to inhibit chronic rejection is an urgent need…
2021 American Transplant Congress
Use of a Novel Bead-based Assay to Measure the Impact of Imlifidase on ABO IgG Antibodies
A. Halpin¹, B. Motyka², T. Ellis², J. Pearcey², T. L. Lowary³, A. Runström⁴, L. Winstedt⁴, R. Bockermann⁴, S. Järnum⁴, A. Robertson⁴, L. J. West⁵
¹Department of Pediatrics and Laboratory Medicine and Pathology, University of Alberta and Alberta Precision Laboratories, Edmonton, AB, Canada, ²Department of Pediatrics, University of Alberta, Edmonton, AB, Canada, ³Department of Chemistry, University of Alberta, Edmonton, AB, Canada, ⁴Hansa Biopharma, Lund, Sweden, ⁵Department of Pediatrics and Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB, Canada
*Purpose: The accurate assessment and measurement of ABO antibodies (ABO-Ab) is a critical component of ABO-incompatible (ABOi) transplantation. ABO-Ab comprise both IgG and IgM, which…
2020 American Transplant Congress
In-Vivo Application of Ides (Imlifidase) in Nonhuman Primates Results in Xenoreactive Desensitization: A Novel Anti-Humoral Therapy
B. P. Lovasik¹, A. J. Matar¹, D. A. Faber¹, D. V. Mathews¹, C. Breeden¹, S. C. Kim¹, A. J. Tector², A. Robertson³, C. Kjellman³, A. B. Adams¹
¹Emory University School of Medicine, Atlanta, GA, ²University of Miami, Miami, FL, ³HANSA Biopharma, Lund, Sweden
*Purpose: Antibody-mediated rejection is a formidable barrier to xenograft survival. A novel anti-humoral IdeS therapy, which cleaves serum IgG, represents a promising therapy to reduce…
2020 American Transplant Congress
Pretransplant BKV-IgG Serostatus and BKV-Specific ELISPOT Assays for the Prediction of BKV Infection
H. Bae¹, J. Jang¹, H. Lee², S. Yun¹, E. Oh³
¹Department of Biomedical Science, Graduate School, Catholic University of Korea, Seoul 137-040, Korea, Republic of, ²Department of Laboratory Medicine, Catholic Kwandong University of Korea, Incheon, Korea, Republic of, ³Department of Laboratory Medicine, Catholic University of Korea, Seoul 137-040, Korea, Republic of
*Purpose: BK Polyomavirus (BK) can lead to major infectious complications and damage to the graft in kidney transplantation (KT). We investigated whether pretransplant BK serostatus…
2020 American Transplant Congress
Carfilzomib-Based Desensitization: Effects on HLA, Non-HLA, Auto, and Antiviral Antibodies
S. Tremblay¹, E. Portwood¹, A. R. Shields², R. R. Alloway¹, P. A. Brailey¹, E. Woodle¹
¹U Cincinnati, Cincinnati, OH, ²U Cincinnati, Christ Hospital, Cincinnati, OH
*Purpose: An important question in plasma cell (PC) therapies is the specificity of therapy for PC populations. It is known that plasmablast populations are exquisitely…
2020 American Transplant Congress
Novel micro-RNA and Microbiome Signature Profiles as Biomarkers for Predicting the Risk of Autoimmune Type 1 Diabetes Development
P. Chhabra¹, G. Ricardo¹, A. Spano², V. Mas¹, M. Timko², K. Brayman¹
¹Dept of Surgery, University of Virginia Health System, Charlottesville, VA, ²Dept of Biology, University of Virginia Health System, Charlottesville, VA
*Purpose: To identify reliable microRNA (miRNA) and microbiome biomarkers for predicting risk of autoimmune beta-cell destruction in type 1 diabetes (T1D) and to investigate alterations…
2020 American Transplant Congress
Renal Safety of Entecavir and Tenofovir with Hepatitis B Immunoglobulin in Liver Transplant Patients
J. Lee¹, E. Kim¹, S. Yang¹, D. Kim², S. Kim¹, J. Park³, H. Choi⁴, B. Kim³, D. Joo¹, M. Kim¹, S. Kim¹, J. Lee¹
¹Department of Transplantation Surgery, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea, Republic of, ²Department of Surgery, Wonju Severance Hospital, Yonsei University College of Medicine, Wonju, Korea, Republic of, ³Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea, Republic of, ⁴Department of Internal Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea, Republic of
*Purpose: Combination of potent nucleos(t)ide analougues (NAs) and hepatitis B immunoglobulin is recommended after liver transplantation for the prevention of hepatitis B virus (HBV) recurrence.…
2020 American Transplant Congress
Long-Term Islet Allo- and Xenograft Survival is Promoted by Immunoglobulin M Immunotherapy
M. Ma, K. Brayman, P. Chhabra
Department of Surgery, University of Virginia Health System, Charlottesville, VA
*Purpose: To investigate if islet allo- and xenotransplant rejection is mitigated by IgM immunotherapy.*Methods: a) New onset diabetic NOD mice (n=14) were treated with IgM…
2020 American Transplant Congress
Recurrence of IgA Nephropathy after Kidney Transplantation – Tango Multicenter Study
A. Uffing¹, P. Cravedi², L. V. Riella¹
¹Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ²Icahn School of Medicine at Mount Sinai, New York, NY
*Purpose: In patients with IgA nephropathy as the cause of ESKD, IgA deposits can recur in the transplanted kidney. However,the incidence and clinical impact of…