ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Immunogenicity"

  • 2016 American Transplant Congress

    Differential Regulation of the Microvascular Endothelial Cell Mediated Allogeneic CD4+ T Cell Response by Anti-HLA-DR and -DQ Alloantibodies in an Inflammatory Context.

    N. Mooney,1,2 A. Cross,1,2 J. Lion,1,2 A. Haziot,1,2 D. Glotz.1,2,3

    1INSERM UMRS 1160, Institut Universitaire d'Hématologie, Paris, France; 2Université-Paris-Diderot, Sorbonne Paris Cité, Paris, France; 3Service de Néphrologie et Transplantation, Hôpital Saint Louis, Paris, France.

    This study examines the basic mechanisms by which high levels of circulating HLA class II donor-specific-antibodies can contribute to microvasculature damage in chronic antibody mediated…
  • 2016 American Transplant Congress

    Blocking MHC Class II on Human Endothelium Mitigates Acute Rejection of Vessel Allografts by Effector Memory T Cells.

    P. Abrahimi,1 L. Qin,2 W. Chang,1 A. Bothwell,1 G. Tellides,2 W. Saltzman,3 J. Pober.1

    1Immunobiology, Yale School of Medicine, New Haven, CT; 2Surgery, Yale School of Medicine, New Haven, CT; 3Biomedical Engineering, Yale University, New Haven, CT.

    Acute allograft rejection is mediated by alloreactive CD8+ T cells that differentiate into cytotoxic lymphocytes (CTL). In most rodent models, CTL differentiate from naïve CD8+…
  • 2016 American Transplant Congress

    Everolimus in Combination with Reduced Dose Tacrolimus Is Effective as a Prophylaxis of Acute Rejection in Low-to-Moderate Immunologic Risk De Novo Kidney Transplantation Patients.

    Y. Qazi, F. Shihab, S. Mulgaonkar, K. MaCague, D. Patel.

    University of Southern California, Los Angeles; University of Utah, Salt Lake City; Barnabas Health, West Orange; Novartis Pharmaceuticals Corporation, East Hanover.

    The US92 study determined whether, in de novo renal transplant patients (pts), concentration-controlled everolimus (EVR) with reduced dose tacrolimus (RTAC) is non-inferior compared to CellCept®…
  • 2016 American Transplant Congress

    Delayed Induction of Mixed Chimerism Permits Kidney-Induced Cardiac Allograft Tolerance to be Applied to Recipients of Cadaveric Organs.

    M. Tonsho,1 G. Benichou,1 R. Yu,1 S. Boskovic,1 R. Colvin,1,2 E. Farkash,2 R.-N. Smith,2 J. Allan,1,4 A. Cosimi,1 T. Kawai,1,3 J. Madsen.1,4

    1Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Boston, MA; 2Department of Pathology, Massachusetts General Hospital, Boston, MA; 3Department of Surgery, Massachusetts General Hospital, Boston, MA; 4Division of Cardiac Surgery, Department of Surgery, Massachusetts General Hospital, Boston, MA.

    (BACKGROUND)Cardiac tolerance in nonhuman primates (NHPs) has been induced for the first time by kidney co-transplantation in combination with donor bone marrow infusion when the…
  • 2016 American Transplant Congress

    Immunogenic HLA-DR Eplet Mismatches as Predictors of Transplant Glomerulopathy.

    D. Blum,1 K. Tinckam,2 M. Marrari,3 J. Kim,2 R. Sapir-Pichhadze.1

    1McGill University, Montreal, Canada; 2University Health Network, Toronto, Canada; 3University of Pittsburgh Medical Center, Pittsburgh.

    BackgroundThe number of HLA-DR eplet mismatches (eplet load) is a risk factor for the development of anti-HLA antibodies and transplant glomerulopathy (TG). In the case…
  • 2016 American Transplant Congress

    High Concentrations of CXCL9 and CXCL10 Chemokines but Not CXCL8 (IL-8), IL-6, TNF-a or IFN-g in Biopsy Tissue Are Associated with Pathological Staging of Rejection After Kidney Transplantation.

    C. Falk,1 C. Neudörfl,1 K. Daemen,1 J. Keil,1 F. Lehner,2 H. Haller,3 J. Schmitz,4 C. Blume,5 J.-H. Bräsen.4

    1Institute of Transplant Immunology, IFB-Tx, Hannover Medical School, Hannover, Germany; 2Department of Abdominal and Transplantation Surgery, Hannover Medical School, Hannover, Deutschland, Germany; 3Department of Nephrology and Hypertension, Hannover Medical School, Hannover, Deutschland, Germany; 4Institute of Pathology, Hannover Medical School, Hannover, Deutschland, Germany; 5Institute of Technical Chemistry, Leibniz University Hannover, Hannover, Deutschland, Germany.

    Background: Extensive expression profiling efforts of biopsy tissue after kidney transplantation indicate that rejection, especially antibody-mediated rejection (AMR) can be defined by distinct signatures. Thus,…
  • 2015 American Transplant Congress

    Immune Rejection of iPS Cells Is Triggered By Gamete-Associated Proteins (GAPs)

    E.-M. Kim, G. Manzar, N. Zavazava.

    Internal Medicine, University of Iowa, Iowa City, IA; Internal Medicine, University of Iowa, Iowa City, IA; Internal Medicine, University of Iowa, Iowa City, IA.

    Induced pluripotent stem (iPS) cells have emerged as a new source for cell based therapies. However, the safety of iPS cells in autologous recipients has…
  • 2015 American Transplant Congress

    Identifying Barriers Specific to Xenoislets by Direct Comparison to Alloislets in a Dual Transplant Model

    K. Samy,1 B. Martin,2 P. Thompson,2 A. Farris,2 M. Song,2 V. Leopardi,1 B. Collins,1 A. Kirk.1

    1Department of Surgery, Duke University Medical Center, Durham, NC; 2Emory Transplant Center, Emory University, Atlanta, GA.

    Purpose:The xenotransplantation of neonatal porcine islets (NPIs) may alleviate the shortage of islets currently limiting islet allotransplantation. However, successful implementation requires understanding of the immune…
  • 2015 American Transplant Congress

    Immunologic, Proangiogenic and Neurogenic Assessment of Allogenic Epineurium of the Human Peripheral Nerve for Potential Application in Prevention of Neuroma Formation

    A. Klimczak,1 K. Futoma,2 A. Jundzill,3 D. Patrzalek,4 M. Siemionow.5

    1Clinical Immunology Department, Institute of Immunology and Experimental Therapy PAS, Wroclaw, Poland; 2Wroclaw Research Centre EIT+, Wroclaw, Poland; 3Regenerative Medicine Tissue Engineering Department, Nicolaus Copernicus University Collegium Medicum, Bydgoszcz, Poland; 4Department of Surgery, 4th Military Clinical Hospital, Wroclaw, Poland; 5Department of Orthopaedics, The University of Illinois at Chicago, Chicago, IL.

    Purpose: Transplantation of epineural sheath may support nerve regeneration after traumatic nerve injuries. Unsolved problem after nerve injury is painful neuroma formation. Natural biologic material,…
  • 2015 American Transplant Congress

    Immunological Evaluation of Acellular Extracellular Matrix Upon Transplantation

    M. Ketaki,1 P. Pradeep,1 N. Nikhil,1 G. Dellgren,3 H. Suchitra, M. Olausson.2

    1Laboratory for Transplantation Regenerative Medicine, Surgery, Gothenburg University, Gothenburg, Sweden; 2Department of Surgery, SU/Sahlgrenska University Hospital, SE 41345, Gothenburg, Sweden; 3Cardiothoracic Surgery, Transplant Institute, Sahlgrenska University Hospital, University of Gothenburg, Gothenburg, Sweden.

    Background : To mitigate the scanty supply of donor organs, porcine tissues can be utilized since, it embrace the potential to accomplish the task of…
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