2016 American Transplant Congress
Immunogenic HLA-DR Eplet Mismatches as Predictors of Transplant Glomerulopathy.
BackgroundThe number of HLA-DR eplet mismatches (eplet load) is a risk factor for the development of anti-HLA antibodies and transplant glomerulopathy (TG). In the case…2016 American Transplant Congress
High Concentrations of CXCL9 and CXCL10 Chemokines but Not CXCL8 (IL-8), IL-6, TNF-a or IFN-g in Biopsy Tissue Are Associated with Pathological Staging of Rejection After Kidney Transplantation.
Background: Extensive expression profiling efforts of biopsy tissue after kidney transplantation indicate that rejection, especially antibody-mediated rejection (AMR) can be defined by distinct signatures. Thus,…2016 American Transplant Congress
A Novel Humanized Mouse Model Incorporating Non-Fetal Tissue.
Surgery/Transplant Division, University of Wisconsin-Madison, Madison, WI.
Pre-clinical research into allogeneic tissue transplantation therapies, as well as patient-specific regenerative medicine studies, require animal models that closely mimic the typical patient's immune response.…2016 American Transplant Congress
Activation of Innate Immunity During Human OLT-IRI Triggers Adaptive Immunity and Correlates with the Degree of IRI Injury.
1Surgery, Dumont-UCLA Transplant Ctr, Los Angeles, CA; 2Pathology, UCLA, Los Angeles, CA.
Ischemia reperfusion injury (IRI) in orthotopic liver transplantation (OLT) can severely compromise graft and recipient survival. We postulate this is mediated by interactions between the…2016 American Transplant Congress
Optimizing the Immunogenicity and Immunomodulatory Properties of MSC for Cellular Therapy.
Mesenchymal stromal cells (MSC) are candidates for immunotherapy after transplantation. MSC have shown to be immunomodulatory and low immunogenic, which is favorable for cellular therapy…2016 American Transplant Congress
Dendritic Cells and Damage-Associated Molecular Patterns in Aging.
Recently, it has been shown that Dendritic Cells (DCs) of old organs accelerate graft rejection by orchestrating IL-17A-mediated T cell responses. Moreover, cell-free DNA has…2015 American Transplant Congress
Immune Rejection of iPS Cells Is Triggered By Gamete-Associated Proteins (GAPs)
Induced pluripotent stem (iPS) cells have emerged as a new source for cell based therapies. However, the safety of iPS cells in autologous recipients has…2015 American Transplant Congress
Identifying Barriers Specific to Xenoislets by Direct Comparison to Alloislets in a Dual Transplant Model
Purpose:The xenotransplantation of neonatal porcine islets (NPIs) may alleviate the shortage of islets currently limiting islet allotransplantation. However, successful implementation requires understanding of the immune…2015 American Transplant Congress
Immunologic, Proangiogenic and Neurogenic Assessment of Allogenic Epineurium of the Human Peripheral Nerve for Potential Application in Prevention of Neuroma Formation
Purpose: Transplantation of epineural sheath may support nerve regeneration after traumatic nerve injuries. Unsolved problem after nerve injury is painful neuroma formation. Natural biologic material,…2015 American Transplant Congress
Immunological Evaluation of Acellular Extracellular Matrix Upon Transplantation
Background : To mitigate the scanty supply of donor organs, porcine tissues can be utilized since, it embrace the potential to accomplish the task of…
American Transplant Congress abstracts