2016 American Transplant Congress
Optimizing the Immunogenicity and Immunomodulatory Properties of MSC for Cellular Therapy.
Mesenchymal stromal cells (MSC) are candidates for immunotherapy after transplantation. MSC have shown to be immunomodulatory and low immunogenic, which is favorable for cellular therapy…2016 American Transplant Congress
Dendritic Cells and Damage-Associated Molecular Patterns in Aging.
Recently, it has been shown that Dendritic Cells (DCs) of old organs accelerate graft rejection by orchestrating IL-17A-mediated T cell responses. Moreover, cell-free DNA has…2016 American Transplant Congress
Biopsy-Proven Rejection in Children After Liver Transplantation Is Associated by an IL-12p40-Mediated Innate Immune Response Followed by Th1 T Cell Activation.
Sustained by adaptive immune cells and their soluble mediators is well established for infection but it has not been demonstrated for solid organ transplantation in…2016 American Transplant Congress
Potent Induction Therapy Improves Graft Outcome in Younger Pancreas Transplant Recipients (<30 Years of Age).
SUNY Upstate Medical University, Syracuse, NY.
Purpose: Pancreas transplants (tx) are increasingly performed in older patients with type 1 diabetes mellitus. This trend may be explained by the significantly higher immunologic…2016 American Transplant Congress
Assessing Return of CMV Specific Cellular Immunity Using the T-SPOT.CMV Soon After Kidney Transplant with Thymoglobulin.
Infectious Disease, Massachusetts General Hospital, Boston, MA.
Background: We do not currently have sufficient predictive tools to determine risk of CMV infection after organ transplantation. Recent data suggest that assays of the…2016 American Transplant Congress
Differential Regulation of the Microvascular Endothelial Cell Mediated Allogeneic CD4+ T Cell Response by Anti-HLA-DR and -DQ Alloantibodies in an Inflammatory Context.
This study examines the basic mechanisms by which high levels of circulating HLA class II donor-specific-antibodies can contribute to microvasculature damage in chronic antibody mediated…2015 American Transplant Congress
Immune Rejection of iPS Cells Is Triggered By Gamete-Associated Proteins (GAPs)
Induced pluripotent stem (iPS) cells have emerged as a new source for cell based therapies. However, the safety of iPS cells in autologous recipients has…2015 American Transplant Congress
Identifying Barriers Specific to Xenoislets by Direct Comparison to Alloislets in a Dual Transplant Model
Purpose:The xenotransplantation of neonatal porcine islets (NPIs) may alleviate the shortage of islets currently limiting islet allotransplantation. However, successful implementation requires understanding of the immune…2015 American Transplant Congress
Immunologic, Proangiogenic and Neurogenic Assessment of Allogenic Epineurium of the Human Peripheral Nerve for Potential Application in Prevention of Neuroma Formation
Purpose: Transplantation of epineural sheath may support nerve regeneration after traumatic nerve injuries. Unsolved problem after nerve injury is painful neuroma formation. Natural biologic material,…2015 American Transplant Congress
Immunological Evaluation of Acellular Extracellular Matrix Upon Transplantation
Background : To mitigate the scanty supply of donor organs, porcine tissues can be utilized since, it embrace the potential to accomplish the task of…
American Transplant Congress abstracts