2022 American Transplant Congress
Pre-Transplantation Liver Immunoadsorption Reduces Liver-Specific Antibody and Complement Deposition without Prolonging Survival in Porcine to Baboon Liver Xenotransplantation
1Massachusetts General Hospital/Harvard Medical School, Boston, MA, 2eGenesis, Inc, Cambridge, MA
*Purpose: Triple knock-out pigs lacking GGTA1, β4GALNT2, CMAH genes are hypothesized to be the optimal donor for human xenotransplantation, however there is evidence that TKO…2020 American Transplant Congress
Impact of Rituximab and Apheresis Techniques in Acute Rejection Rates in ABO Incompatible Living Donor Kidney Transplant
*Purpose: ABO incompatibility (ABOi) is a widespread option of living kidney donor transplantation (LKDT). However, controversies in rejection, and death-censored graft survival rates are published,…2019 American Transplant Congress
Eight-Year Outcomes Following ABO-Incompatible Kidney Transplantation Performed after Desensitization by Antigen-Unspecific Immunoadsorption Devices
*Purpose: Owing to the unmet need of available kidney grafts, ABO-incompatible kidney transplantation (KTX) has been established to enlarge the possible donor pool. The current…2019 American Transplant Congress
Successful Use of Nonantigen Specific Immunoadsorption In ABO-Incompatible Desensitization and Humoral Rejection Treatment in Kidney Transplantation
Servei de Nefrologia i Trasplantament Renal, Hospital Clínic de Barcelona, Barcelona, Spain
*Purpose: : Immunoadsorption (IA) is an apheresis procedure that has been shown to be effective in the ABO incompatible living donor kidney transplantation (ABOi LDKT)…2018 American Transplant Congress
AT1R Antibody Analysis: High Proportion of Non-Specific Reactivity?
INTRODUCTION:The angiotensin II type 1 receptor (AT1R) is expressed on vascular endothelium. AT1R antibodies (Ab) have been studied to examine their relevance in renal and…2018 American Transplant Congress
Immuoadsorption-Based Desensitization in Highly Sensitized Patients Awaiting Deceased Donor Kidney Transplantation.
Urgences Néphrologiques et Transplantation Rénale, Tenon Hospital, APHP, Paris, France.
An estimated 30% of patients on the waiting list are deemed highly sensitized due to preexisting anti-HLA antibodies often irrevocably precluding kidney transplantation (KT). Immunoadsorption…2018 American Transplant Congress
HLA Desensitization Using Rituximab/ Immunoadsorption before Kidney Transplantation
Nephrology, Hemodialyis, Apheresis and Transplantation, CHU Grenoble-Alpes, Grenoble, France.
Introduction: Many kidney-transplant (KT) candidates are sensitized against HLA-antigens, making it difficult to find a suitable HLA-compatible donor. Pretransplant HLA-desensitization strategies have shown improved patient…2018 American Transplant Congress
Pretransplant Use of Rituximab is Associated with Posttransplant Malignancies Events and Death by Neoplasia in Incompatibility Living Donor Kidney Transplants
Introduction: Incompatibilities is a challenge in kidney transplantation. Potent immunosuppression approach based on desensitization protocols (DS) are usually needed; However, controversies in results and lack…2017 American Transplant Congress
Differential Effect of Antibody Removal on ABO Blood Group Type Chain Specific Antibodies Over Time.
Introduction: The trisaccharide epitope defines A&B blood group antigens where antibody binds to subtype chains (I-VI), but only subtype II is expressed on cardiac vascular…2016 American Transplant Congress
Deceased Non-A2 Donor ABO-Incompatible Liver Transplantation – Promising Results with Anti-A/B Antibody Reduction Both Pre- and Post-Transplant.
IntroductionOne way to expand the donor pool for patients with acute liver failure could be to use deceased donor (DD) ABO-incompatible (ABOi) liver grafts. However,…
American Transplant Congress abstracts