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American Transplant Congress abstracts

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Articles tagged "Immunoadsorption"

  • 2022 American Transplant Congress

    Pre-Transplantation Liver Immunoadsorption Reduces Liver-Specific Antibody and Complement Deposition without Prolonging Survival in Porcine to Baboon Liver Xenotransplantation

    D. J. Cloonan1, T. Coe1, N. Serifis1, R. Matheson1, S. Maggipinto1, D. Firl1, R. Anand2, J. Layer2, L. Queiroz2, K. Stiede2, K. Hall2, M. Youd2, W. Qin2, M. Curtis2, S. Kimura1, I. Rosales1, J. Markmann1

    1Massachusetts General Hospital/Harvard Medical School, Boston, MA, 2eGenesis, Inc, Cambridge, MA

    *Purpose: Triple knock-out pigs lacking GGTA1, β4GALNT2, CMAH genes are hypothesized to be the optimal donor for human xenotransplantation, however there is evidence that TKO…
  • 2020 American Transplant Congress

    Impact of Rituximab and Apheresis Techniques in Acute Rejection Rates in ABO Incompatible Living Donor Kidney Transplant

    I. Revuelta1, E. De Sousa-Amorim1, M. Lozano2, D. Cucchiari1, J. Cid2, L. Peri3, E. Palou4, M. Musquera3, J. Martorell5, J. M. Campistol1, F. Oppenheimer1, F. Diekmann1

    1Renal Transplant Unit, Department of Nephrology and Kidney Transplant, Hospital Clinic, Barcelona, Spain, 2Apheresis and Cellular Therapy Unit, Hospital Clinic, Barcelona, Spain, 3Department of Urology, Hospital Clinic, Barcelona, Spain, 4Histocompatibility Lab. Department of Immunology, Hospital Clinic, Barcelona, Spain, 5Histocompatibility Lab, Department of Immunology, Hospital Clinic, Barcelona, Spain

    *Purpose: ABO incompatibility (ABOi) is a widespread option of living kidney donor transplantation (LKDT). However, controversies in rejection, and death-censored graft survival rates are published,…
  • 2019 American Transplant Congress

    Eight-Year Outcomes Following ABO-Incompatible Kidney Transplantation Performed after Desensitization by Antigen-Unspecific Immunoadsorption Devices

    C. Speer1, F. Kälble1, L. Pego da Silva1, C. Nusshag1, M. Schaier1, C. Süsal2, C. Sommerer1, M. Zeier1, C. Morath1

    1Nephrology, University of Heidelberg, Heidelberg, Germany, 2Immunology, University of Heidelberg, Heidelberg, Germany

    *Purpose: Owing to the unmet need of available kidney grafts, ABO-incompatible kidney transplantation (KTX) has been established to enlarge the possible donor pool. The current…
  • 2019 American Transplant Congress

    Successful Use of Nonantigen Specific Immunoadsorption In ABO-Incompatible Desensitization and Humoral Rejection Treatment in Kidney Transplantation

    E. Montagud-Marrahi

    Servei de Nefrologia i Trasplantament Renal, Hospital Clínic de Barcelona, Barcelona, Spain

    *Purpose: : Immunoadsorption (IA) is an apheresis procedure that has been shown to be effective in the ABO incompatible living donor kidney transplantation (ABOi LDKT)…
  • 2018 American Transplant Congress

    AT1R Antibody Analysis: High Proportion of Non-Specific Reactivity?

    A. Halpin,1,3,4,5 S. Abou-Zeki,3 I. Larsen,1,4 P. Campbell,2,3,4,5 S. Urschel,1,4,5 L. West.1,3,4,5

    1Dept of Pediatrics, U of Alberta, Edmonton, Canada; 2Dept of Medicine, U of Alberta, Edmonton, Canada; 3Dept of Lab Medicine & Pathology, U of Alberta, Edmonton, Canada; 4ATI, , Canada; 5CNTRP, , Canada.

    INTRODUCTION:The angiotensin II type 1 receptor (AT1R) is expressed on vascular endothelium. AT1R antibodies (Ab) have been studied to examine their relevance in renal and…
  • 2018 American Transplant Congress

    Immuoadsorption-Based Desensitization in Highly Sensitized Patients Awaiting Deceased Donor Kidney Transplantation.

    C. Bureau, P. Galichon, Y. Luque, N. Ouali, E. Rondeau, C. Rafat.

    Urgences Néphrologiques et Transplantation Rénale, Tenon Hospital, APHP, Paris, France.

    An estimated 30% of patients on the waiting list are deemed highly sensitized due to preexisting anti-HLA antibodies often irrevocably precluding kidney transplantation (KT). Immunoadsorption…
  • 2018 American Transplant Congress

    HLA Desensitization Using Rituximab/ Immunoadsorption before Kidney Transplantation

    P. Malvezzi, T. Jouve, D. Masson, J. Maurizi, B. Bardy, P-.L. Carron, B. Janbon, N. Terrier, L. Rostaing.

    Nephrology, Hemodialyis, Apheresis and Transplantation, CHU Grenoble-Alpes, Grenoble, France.

    Introduction: Many kidney-transplant (KT) candidates are sensitized against HLA-antigens, making it difficult to find a suitable HLA-compatible donor. Pretransplant HLA-desensitization strategies have shown improved patient…
  • 2018 American Transplant Congress

    Pretransplant Use of Rituximab is Associated with Posttransplant Malignancies Events and Death by Neoplasia in Incompatibility Living Donor Kidney Transplants

    I. Revuelta,1,2,3,4 V. Tubita,2 D. Cucchiari,1,2 E. De Sousa,1 P. Piselli,5 M. Lozano,6 J. Cid,6 E. Palou,7 J. Martorell,7 F. Oppenheimer,1,2,3,4 F. Diekmann,1,2,3,4 J. Campistol.1,2,3,4

    1Renal Transplant Unit. Department of Nephrology and Kidney Transplant. Hospital Clinic, Barcelona, Spain; 2Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain; 3REDINREN, Madrid, Spain; 4Barcelona University, Barcelona, Spain; 5Dipartamento di Epidemiologia e Ricerca Pre-Clinica. IRCCC, Roma, Italy; 6Department of Apheresis. Hospital Clinic, Barcelona, Spain; 7Department of Immunology. Hospital Clinic, Barcelona, Spain.

    Introduction: Incompatibilities is a challenge in kidney transplantation. Potent immunosuppression approach based on desensitization protocols (DS) are usually needed; However, controversies in results and lack…
  • 2017 American Transplant Congress

    Differential Effect of Antibody Removal on ABO Blood Group Type Chain Specific Antibodies Over Time.

    A. Bentall,1 M. Jeyakanthan,2 J. Pearcey,2 B. Motyka,2 C. Cairo,3 T. Lowary,3 J. Buriak,4 L. West,2 S. Ball.1

    1Department of Nephrology, University Hospital Birmingham, Birmingham, United Kingdom; 2Departs of Pediatrics, Surgery and Immunology, University of Alberta, Alberta Transplant Institute, Edmonton, Canada; 3Alberta Glycomics Centre, Univ of Alberta, Dept of Chemistry, Edmonton, Canada; 4Dept of Chemistry, National Institute of Nanotechnology, Edmonton, Canada

    Introduction: The trisaccharide epitope defines A&B blood group antigens where antibody binds to subtype chains (I-VI), but only subtype II is expressed on cardiac vascular…
  • 2016 American Transplant Congress

    ABO Incompatible Living Related Kidney Transplantation: Results of a Matched-Pair Analysis with ABO Compatible Living Donation.

    T. Vowinkel,1 H. Wolters,2 S. Reuter,3 T. Vogel,1 N. Senninger,1 B. Suwelack.3

    1Department of General and Visceral Surgery, University Hospital Muenster, Muenster, Germany; 2Department of General and Visceral Surgery, St. Josef's Hospital, Dortmund, Germany; 3Department of Internal Medicine D, University Hospital Muenster, Muenster, Germany.

    Background: Organ shortage has led to an increase in living related kidney transplantation of ABO compatible (ABOc) as well as ABO incompatible (ABOi) organs. Here…
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