2022 American Transplant Congress
Degree of Pre-Liver Transplant Immune Dysfunction Correlates with Post-Transplant Cancer Recurrence
1Rutgers New Jersey Medical School, Newark, NJ, 2Houston Methodist Hospital, Houston, TX
*Purpose: Despite stringent selection criteria for liver transplant (LT) in patients with liver-limited malignancy, post-transplant cancer recurrence remains problematic. We have previously identified a pre-LT…2022 American Transplant Congress
Alloimmune Recognition Blocks Recipient Macrophage Differentiation into Reparative Subsets
*Purpose: Monocytes differentiate into macrophage subsets that orchestrate tissue repair in response to damage signals and local cytokines. After heart transplant (Tx), graft IL-33 acts…2022 American Transplant Congress
Internal Validation of a Pre-Transplant Biomarker Panel to Predict Post-Transplant Mortality: The Liver Immune Frailty Index
1Rutgers New Jersey Medical School, Newark, NJ, 2Houston Methodist Hospital, Houston, TX
*Purpose: Infection and sepsis are the greatest contributors to early post-liver transplant (LT) mortality. These often result from ongoing immune dysfunction, or “Immune Frailty”. We…2022 American Transplant Congress
Early Mortality After Liver Transplant is Associated with Pre-Transplant Alterations in Monocyte Phenotype and Gene Expression
*Purpose: Persistence of pre-liver transplant (LT) immune dysfunction (immune frailty) significantly increases post-LT morbidity and mortality. We have identified a pre-LT biomarker panel, the liver…2021 American Transplant Congress
Hypothermic Oxygenated Machine Perfusion Protects Against Cholangiocyte and Hepatocyte Injury and Mitigates Inflammation vs Static Cold Storage: Preliminary Results from a Single Center
Transplant Surgery, Rutgers NJMS, Newark, NJ
*Purpose: Hypothermic-oxygenated machine perfusion (HMP-O2) is a promising preservation technique with potential to mitigate ischemia/reperfusion injury and improve graft and patient outcomes. Here we present…2021 American Transplant Congress
The Gut Microbiotainduces Local and Systemic Immune Modulation
*Purpose: We previously demonstrated that gut microbiome alterations, through fecal microbiota transfer (FMT) or single bacteria transfer, had specific immune effects for cardiac allograft outcome.…2021 American Transplant Congress
Human Liver-derived Mesenchymal Stromal Cells (MSC) are Superior Inhibitors of Natural Killer Cells Compared to Bone Marrow or Adipose Tissue-derived MSC
*Purpose: Guided by the liver allografts’ unique tolerogenic microenvironment and the immunoprotective impact on simultaneously transplanted organs, we recently isolated liver mesenchymal stromal cells (L-MSC)…2021 American Transplant Congress
Laminins Differentially Regulate Tolerogenic T Cell Migration and Homing to Lymph Nodes
1Surgery, UMB, Baltimore, MD, 2CVID, UMB, Baltimore, MD, 3Harvard University, Boston, MA
*Purpose: Laminin α5 (Lama5) and α4 (Lama4), which are produced by lymph node (LN) stromal cells, influence CD4 T cell migration and stimulation. We hypothesized…2021 American Transplant Congress
Dysregulation of Immune Cell Glycolysis and Oxidative Phosphorylation Correlates with Development of Pre-liver Transplant Immune Dysfunction and Post-transplant Mortality
*Purpose: Cirrhosis-related immune dysfunction contributes to early morbidity and mortality following liver transplant (LT). We have previously identified a pre-LT biomarker panel, the immune frailty…2020 American Transplant Congress
The Gut Microbiota Stimulates Dendritic Cells for Immune Modulation
University of Maryland, Baltimore, Baltimore, MD
*Purpose: The gut microbiota is a driving force in host immune regulation, and thus a potential target for intervention and drug development. We previously showed…
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