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American Transplant Congress abstracts

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Articles tagged "Immune deviation"

  • 2022 American Transplant Congress

    Early Mortality After Liver Transplant is Associated with Pre-Transplant Alterations in Monocyte Phenotype and Gene Expression

    L. Jin1, A. Lemenze2, G. Panayotova1, S. Simonishvili1, Y. Qin1, T. Ayorinde1, G. Prakash1, L. J. Minze3, F. Paterno1, L. Brown1, A. Amin1, X. C. Li3, R. Ghobrial3, J. V. Guarrera1, K. E. Lunsford1

    1Department of Surgery, Rutgers New Jersey Medical School, Newark, NJ, 2Center for Immunity and Inflammation, Rutgers Biomedical and Health Sciences, Newark, NJ, 3J.C. Walter Jr. Center for Transplantation, Houston Methodist Hospital, Houston, TX

    *Purpose: Persistence of pre-liver transplant (LT) immune dysfunction (immune frailty) significantly increases post-LT morbidity and mortality. We have identified a pre-LT biomarker panel, the liver…
  • 2022 American Transplant Congress

    Degree of Pre-Liver Transplant Immune Dysfunction Correlates with Post-Transplant Cancer Recurrence

    G. S. Prakash1, G. G. Panayotova1, S. Simonishvili1, Y. Qin1, L. Jin1, T. Ayorinde1, L. J. Minze2, F. Paterno1, L. Brown1, A. Amin1, D. Liu1, R. Ghobrial2, J. V. Guarrera1, K. E. Lunsford1

    1Rutgers New Jersey Medical School, Newark, NJ, 2Houston Methodist Hospital, Houston, TX

    *Purpose: Despite stringent selection criteria for liver transplant (LT) in patients with liver-limited malignancy, post-transplant cancer recurrence remains problematic. We have previously identified a pre-LT…
  • 2022 American Transplant Congress

    Alloimmune Recognition Blocks Recipient Macrophage Differentiation into Reparative Subsets

    J. Warunek1, A. Lucas2, L. R. Mathews2, M. Oberbarnscheidt2, F. Lakkis2, H. Turnquist2

    1Immunology, Thomas E. Starzl Transplantation Institute, University at Pittsburgh, Pittsburgh, PA, 2Surgery, Thomas E. Starzl Transplantation Institute, Pittsburgh, PA

    *Purpose: Monocytes differentiate into macrophage subsets that orchestrate tissue repair in response to damage signals and local cytokines. After heart transplant (Tx), graft IL-33 acts…
  • 2022 American Transplant Congress

    Internal Validation of a Pre-Transplant Biomarker Panel to Predict Post-Transplant Mortality: The Liver Immune Frailty Index

    G. G. Panayotova1, D. T. Nguyen2, E. A. Graviss2, L. J. Minze2, S. Simonishvili1, Y. Qin1, T. Ayorinde1, G. Prakash1, F. Paterno1, L. Brown1, A. Amin1, X. C. Li2, R. M. Ghobrial2, J. V. Guarrera1, K. E. Lunsford1

    1Rutgers New Jersey Medical School, Newark, NJ, 2Houston Methodist Hospital, Houston, TX

    *Purpose: Infection and sepsis are the greatest contributors to early post-liver transplant (LT) mortality. These often result from ongoing immune dysfunction, or “Immune Frailty”. We…
  • 2021 American Transplant Congress

    Hypothermic Oxygenated Machine Perfusion Protects Against Cholangiocyte and Hepatocyte Injury and Mitigates Inflammation vs Static Cold Storage: Preliminary Results from a Single Center

    G. Panayotova, F. Paterno, M. McCarty, G. Dikdan, S. Simonishvili, Y. Qin, L. Brown, A. Amin, K. E. Lunsford, J. V. Guarrera

    Transplant Surgery, Rutgers NJMS, Newark, NJ

    *Purpose: Hypothermic-oxygenated machine perfusion (HMP-O2) is a promising preservation technique with potential to mitigate ischemia/reperfusion injury and improve graft and patient outcomes. Here we present…
  • 2021 American Transplant Congress

    The Gut Microbiotainduces Local and Systemic Immune Modulation

    V. Saxena, R. Lakhan, J. Iyyathurai, W. Piao, L. Li, T. Zhang, M. W. Shirkey, B. Ma, E. F. Mongodin, J. Bromberg

    U Maryland, Baltimore, MD

    *Purpose: We previously demonstrated that gut microbiome alterations, through fecal microbiota transfer (FMT) or single bacteria transfer, had specific immune effects for cardiac allograft outcome.…
  • 2021 American Transplant Congress

    Human Liver-derived Mesenchymal Stromal Cells (MSC) are Superior Inhibitors of Natural Killer Cells Compared to Bone Marrow or Adipose Tissue-derived MSC

    F. Yigitbilek, M. J. Hansen, W. D. Park, M. D. Stegall, T. Taner

    Mayo Clinic, Rochester, MN

    *Purpose: Guided by the liver allografts’ unique tolerogenic microenvironment and the immunoprotective impact on simultaneously transplanted organs, we recently isolated liver mesenchymal stromal cells (L-MSC)…
  • 2021 American Transplant Congress

    Laminins Differentially Regulate Tolerogenic T Cell Migration and Homing to Lymph Nodes

    L. Li1, M. Shirkey1, W. Piao1, Y. Xiong1, V. Saxena2, T. Zhang1, J. Iyyathurai2, R. Lakhan1, R. Abdi3, J. Bromberg1

    1Surgery, UMB, Baltimore, MD, 2CVID, UMB, Baltimore, MD, 3Harvard University, Boston, MA

    *Purpose: Laminin α5 (Lama5) and α4 (Lama4), which are produced by lymph node (LN) stromal cells, influence CD4 T cell migration and stimulation. We hypothesized…
  • 2021 American Transplant Congress

    Dysregulation of Immune Cell Glycolysis and Oxidative Phosphorylation Correlates with Development of Pre-liver Transplant Immune Dysfunction and Post-transplant Mortality

    G. Panayotova1, L. Jin1, A. Lemenze1, S. Simonishvili1, Y. Qin1, L. Minze2, G. Dikdan1, F. Paterno1, X. C. Li2, M. Ghobrial2, J. V. Guarrera1, K. E. Lunsford1

    1Transplant Surgery, Rutgers NJMS, Newark, NJ, 2Transplant Surgery, Houston Methodist Hospital, Houston, TX

    *Purpose: Cirrhosis-related immune dysfunction contributes to early morbidity and mortality following liver transplant (LT). We have previously identified a pre-LT biomarker panel, the immune frailty…
  • 2020 American Transplant Congress

    The Gut Microbiota Stimulates Dendritic Cells for Immune Modulation

    V. Saxena, W. Piao, L. Hittle, L. Li, T. Simon, C. Palusckievicz, Y. Xiong, T. Zhang, M. Shirkey, E. F. Mongodin, J. S. Bromberg

    University of Maryland, Baltimore, Baltimore, MD

    *Purpose: The gut microbiota is a driving force in host immune regulation, and thus a potential target for intervention and drug development. We previously showed…
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