Articles tagged "Image analysis"

2020 American Transplant Congress
Photo Elicitation Interviewing Exposes Educational Discordance Amidst a Web of Resources among Kidney Transplant Recipients
J. R. Montgomery, M. J. Kirsch, A. Rau, M. E. Byrnes, S. A. Waits
General Surgery, University of Michigan, Ann Arbor, MI
*Purpose: Comprehensive patient education is the bedrock of success for kidney transplant (KT) recipients. Despite the importance, we have a poor understanding of how patients…
2020 American Transplant Congress
Hyperspectral Imaging of Human Kidney Allografts
R. Sucher¹, H. Köhler², A. Lederer¹, H. M. Hau¹, I. Gockel¹, D. Seehofer¹
¹Department of Visceral, Transplant-, Thoracic and Vascular Surgery, University Clinic Leipzig, Leipzig, Germany, ²Innovation Center for Computer Assisted Surgery, University Clinic Leipzig, Leipzig, Germany
*Purpose: Hyperspectral imaging (HSI) is capable to deliver non-contact, non-ionizing and non-invasive quantitative diagnostic information about tissue pathology, morphology and composition, based on the spectral…
2020 American Transplant Congress
Accelerated Decline in Glomerular Density: An Unrecognized Pathologic Process after Kidney Transplantation
A. Denic, B. H. Smith, W. D. Park, M. V. Luhman, M. P. Alexander, A. D. Rule, M. D. Stegall
Mayo Clinic, Rochester, Rochester, MN
*Purpose: Studies in healthy adults have shown that glomerular density slowly declines with older age (-0.5% per decade), and globally sclerotic glomeruli (GSG) slowly increase…
2020 American Transplant Congress
Kidney Cortical Wedge Biopsies for Human Organ Research: Does Anatomic Variability Impact Their Utility?
C. M. Edwards¹, J. T. Langford¹, M. Reschke², J. R. DiRito¹, D. Mulligan¹, D. Haakinson¹, G. T. Tietjen¹
¹Surgery, Yale School of Medicine, New Haven, CT, ²Biomedical Engineering, Yale University, New Haven, CT
*Purpose: The purpose of this study is to characterize human kidney anatomic variability both within singular biopsies and between biopsy sites in order to investigate…
2020 American Transplant Congress
Computer-Assisted Cardiac Histologic Evaluation (CACHE) for Grading Cardiac Allograft Rejection
E. Peyster¹, S. ArabYarmohommadi², A. Janowczyk², M. Sekulic³, C. Cassol⁴, M. Feldman¹, K. Margulies¹, A. Madabhushi²
¹University of Pennsylvania, Philadelphia, PA, ²Case Western Reserve University, Cleveland, OH, ³University Hospitals Cleveland Medical Center, Cleveland, OH, ⁴Ohio State University, Columbus, OH
*Purpose: Cardiac allograft rejection (CAR) is a serious concern in heart transplantation, occurring in 30-40% of patients during the first year. Endomyocardial biopsy (EMB) with…
2020 American Transplant Congress
Noninvasive Imaging of CD122+ T Cells via Immuno-PET for Detection of Acute Cellular Rejection
A. J. Matar¹, B. P. Lovasik¹, D. Vanover², L. Rotolo², Y. Dong¹, D. A. Faber¹, D. V. Mathews¹, W. H. Kitchens¹, P. Santangelo², A. B. Adams¹
¹Surgery and Transplantation, Emory University, Atlanta, GA, ²Biomedical Engineering, Georgia Tech, Atlanta, GA
*Purpose: Acute cellular rejection (ACR) remains a clinically important problem following organ transplantation. Clinically, suspicion of ACR is dependent upon serum laboratory values, and diagnosis…
2020 American Transplant Congress
Imaging OX40+Alloreactive T Cells Provides Early Warning of Organ Transplant Rejection
T. Hirai¹, A. Mayer², T. W. Nobashi², Z. Xiao², T. Udagawa³, K. Seo⁴, F. Simonetta⁵, J. Baker⁵, A. Cheng³, S. S. Gambhir², R. S. Negrin⁵
¹Department of Urology, Tokyo Women's Medical University, Tokyo, Japan, ²Department of Radiology, Stanford University, Stanford, CA, ³Department of Otolaryngology-Head and Neck Surgery, Stanford University, Stanford, CA, ⁴Division of Cardiovascular Medicine, Stanford University, Stanford, CA, ⁵Division of Blood and Marrow Transplantation, Stanford University, Stanford, CA
*Purpose: Diagnosis of organ transplant rejection relies upon biopsy approaches to confirm alloreactive T cell infiltration in the graft. Immuno positron emission tomography (immunoPET) utilizing…
2019 American Transplant Congress
Digital Imaging Software vs. the “Eyeball” Method in Quantifying Steatosis in a Liver Biopsy
J. Long¹, J. Motter¹, S. Besharati¹, S. Jerman², R. Anders¹, A. Ortiz², D. Bowman², T. Dunn³, D. Lee⁴, A. Massie¹, R. Barth⁵, B. Philosophe¹
¹Johns Hopkins, Baltimore, MD, ²Indica Labs, Corrales, NM, ³UPenn, Philadelphia, PA, ⁴Mayo Clinic, Jacksonville, FL, ⁵University of MD, Baltimore, MD
*Purpose: The use of steatotic livers is controversial, but may represent an underutilized resource to increase the donor pool. Although
2019 American Transplant Congress
Ex Vivo Normothermic Perfusion Of Discarded Human Kidneys Reveals Cold-storage-induced Renal Fibrinogen And Provides A Platform For Therapeutic Repair
J. DiRito¹, S. A. Hosgood², M. Reschke³, M. L. Nicholson², G. T. Tietjen⁴
¹Surgery, Yale University & University of Cambridge, New Haven, CT, ²Surgery, University of Cambridge, Cambridge, United Kingdom, ³Biomedical Engineering, Yale University, New Haven, CT, ⁴Surgery - Transplantation, Yale University, New Haven, CT
*Purpose: The purpose of this study was to: 1) determine the cause of microvascular obstructions that arise during ex vivo normothermic perfusion (NMP) of human…
2019 American Transplant Congress
Indocyanine Green Fluorescence Imaging during Normothermic Ex Vivo Liver Perfusion for the Assessment of Hepatocyte, Biliary, and Vascular Function
T. Goto, I. Linares, S. Ganesh, L. Mazilescu, P. Urbanellis, N. Selzner, M. Selzner
Multi-Organ Transplant Program, Department of Surgery, Toronto General Hospital, Toronto, ON, Canada
*Purpose: Normothermic Ex Vivo Liver Perfusion (NEVLP) is a novel preservation for the storage and assessment of marginal grafts, such as Donation after Cardio-circulatory Death…