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Articles tagged "Image analysis"

  • 2021 American Transplant Congress

    The Microenvironment of Belatacept-Resistant Rejection

    A. Johnson, J. Zhang, C. Larsen

    Surgery, Emory University, Atlanta, GA

    *Purpose: Belatacept is a co-stimulation blockade immunosuppressant, that despite demonstrating improved long-term outcomes, has not been widely adopted, in part, due to concern over early…
  • 2021 American Transplant Congress

    Patterns and Inhibition of Cell Death During Static Cold Storage of Human Kidneys

    J. R. DiRito1, G. Chickering2, J. T. Langford1, D. Stern1, S. Hosgood3, M. L. Nicholson3, E. Gavathiotis4, R. N. Kitsis5, M. Saltzman2, J. S. Pober6, G. T. Tietjen7

    1Surgery, Yale School of Medicine, New Haven, CT, 2Biomedical Engineering, Yale University, New Haven, CT, 3Surgery, University of Cambridge, Cambridge, United Kingdom, 4Biochemistry and Medicine, Wilf Family Cardiovascular Research Institute, Albert Einstein College of Medicine, Bronx, NY, 5Surgery, Albert Einstein College of Medicine, Bronx, NY, 6Immunobiology, Yale University, New Haven, CT, 7Surgery and Biomedical Engineering, Yale School of Medicine, New Haven, CT

    *Purpose: As the donor population continues to age and accumulate co-morbidities, more marginal kidneys are being retrieved for transplantation. However, estimates suggest that more than…
  • 2021 American Transplant Congress

    The Tumor-suppressor Signaling of the α1-na/k-atpase- Cav-1-src Complex at the Caveola in Nash Related Hepatocellular Carcinoma

    U. S. Udoh1, J. D. Sanabria1, M. Banerjee1, P. K. Rajan1, M. Schade1, J. A. Sanabria1, A. Mallick1, G. Smith1, G. U. Udoh2, K. Sodhi1, S. Pierre2, Z. Xie2, J. Shapiro2, J. Sanabria1

    1Dept. of Surgery/ Marshall Institute for Interdisciplinary Research, Marshall University, Huntington,, WV, 2Marshall Institute for Interdisciplinary Research, Marshall University, Huntington,, WV

    *Purpose: Hepatocellular Carcinoma (HCC) is the 2nd and fastest-growing cause of cancer related mortality worldwide, mainly from the metabolic cellular disturbances promoted by the epidemic…
  • 2020 American Transplant Congress

    Multiplexed Imaging Mass Cytometry Analysis Reveals a New Role for CD68+ Macrophages in Chronic Liver Transplant Rejection

    J. Emamaullee, C. Man, J. Hoeflich, N. Ung, R. Sun, N. Matasci, J. Katz, J. Lee, S. Chopra, L. Sher, S. Asgharzadeh, O. Akbari, Y. Genyk

    University of Southern California, Los Angeles, CA

    *Purpose: Rejection continues to be an important cause of graft loss and failure post-liver transplant (LT). Recently, a novel high-resolution mass spectrometry-based technique has been…
  • 2020 American Transplant Congress

    High Laminin Alpha 5 Expression is Observed in the Pancreas of Chronic Pancreatitis Patients and Correlates with Poor Autologous Islet Transplant Outcome

    Y. Liu, K. Kumano, S. Vasu, C. M. Darden, M. Lawrence, B. Naziruddin

    Baylor University Medical Ctr, Dallas, TX

    *Purpose: During chronic pancreatitis (CP), the extracellular matrix (ECM) of the pancreas is destroyed by a vicious cycle of parenchymal autodigestion by digestive exocrine enzymes…
  • 2020 American Transplant Congress

    Deep Learning for Living Donor Surgery: AI Recognition of Surgical Video to Develop Navigation Systems for Laparoscopic Nephrectomy

    M. Nishihara1, K. Iwadoh2, M. Noriyuki1, I. Koyama2, I. Nakajima2, M. Tonsho1

    1Transplant Surgery, International University of Health and Welfare, Mita Hospital, Tokyo, Japan, 2Kidney Surgery, Tokyo Women's Medical University Hospital, Tokyo, Japan

    *Purpose: Laparoscopic surgery for living donors requires high safety, thus establishing of navigation system for surgical operation is urged. The purpose of this study was…
  • 2020 American Transplant Congress

    Prognostic Impact of Peritumoral Neutrophil Infiltration on Hepatocellular Carcinoma Recurrence Following Liver Transplantation

    M. Najjar1, K. Halazun2, M. Mondal1, A. Srivastava1, M. Moore1, E. Rizk1, R. Gartrell1, H. Remotti1, L. Fazlollahi1, E. Verna1, A. Griesemer1, A. Mathur1, B. Samstein2, J. Emond1, Y. Saenger1

    1Columbia University Irving Medical Center, New York, NY, 2Weill Cornell Medicine, New York, NY

    *Purpose: Peritumoral neutrophil (PMN) infiltration has been associated with poor clinical outcomes in various tumors; however, its role in hepatocellular carcinoma (HCC) remains understudied. Moreover,…
  • 2020 American Transplant Congress

    Neonatal Tolerance Induction: Behaviours of Allogeneic Spleen and Bone Marrow Inocula in Neonatal Mice are Largely Determined by the Nature of Their CD8 T Cells

    R. A. Bascom, K. Tao, L. J. West

    University of Alberta, Edmonton, AB, Canada

    *Purpose: Injected adult allo-spleen (SC) and bone marrow cells (BMC) traffic to secondary lymphoid organs, proliferate and spread throughout neonatal mice; allo-SC consistently cause acute…
  • 2020 American Transplant Congress

    Steatosis by PDFF Affects Percent Remnant Liver Regeneration in Living Donors without Impacting on Clinical Outcomes

    A. Duarte-Rojo, Q. Qi, K. Chupetlovska, D. R. Jorgensen, A. A. Borhani, A. Furlan, S. Ganesh, A. Humar

    University of Pittsburgh Medical Center, Pittsburgh, PA

    *Purpose: Mild steatosis (5-33% of fat) is not expected to affect liver regeneration following partial hepatectomy. Novel methods to assess steatosis, such as proton density…
  • 2020 American Transplant Congress

    Impact of Kidney Transplant Type and Previous Transplant on Baseline Donor-Derived Cell Free DNA

    K. K. Sureshkumar, B. Chopra

    Nephrology and Hypertension, Allegheny General Hospital, Pittsburgh, PA

    *Purpose: Donor derived-cell free DNA (dd-cfDNA) is a biomarker useful in predicting acute rejection in renal allografts. The technology uses next generation sequencing and does…
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