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American Transplant Congress abstracts

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Articles tagged "Image analysis"

  • 2021 American Transplant Congress

    Novel Morphologic Biomarkers of Cardiac Allograft Remodeling are Associated with Multiple Peri- and Post-transplant Inflammatory Processes

    C. Yuan1, S. Arabyarmohammadi1, H. Li1, E. Peyster2, P. Lal3, M. Feldman3, K. Margulies2, A. Madabhushi1

    1Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, 2Cardiovascular Research Institute, University of Pennsylvania, Philadelphia, PA, 3University of Pennsylvania, Philadelphia, PA

    *Purpose: It has long been recognized that transplanted hearts develop a stiffened, restrictive physiology at an accelerated rate compared to native hearts. While this is…
  • 2021 American Transplant Congress

    Indocyanine Green Fluorescence Imaging Allows Quantification of Ischemic Injury During Porcine Normothermic Ex Situ Perfusion

    T. Goto, Y. Noguchi, S. Ganesh, L. Mazilescu, T. Reichman, N. Selzner, M. Selzner

    Ajmera Transplant Program, Department of Surgery, Toronto General Hospital, Toronto, ON, Canada

    *Purpose: Normothermic Ex Situ Liver Perfusion (NEsLP) is a novel preservation technique for the storage and assessment of grafts retrieved after Donation after Cardio-circulatory Death…
  • 2021 American Transplant Congress

    Dissecting the Intrarenal Immune Response to Viral Infected Cells in Pediatric BK Virus-associated Nephropathy (BKVAN)

    D. M. Okamura1, S. W. Jackson1, V. R. Dharnidharka2, J. M. Smith1

    1Pediatric Nephrology, Seattle Children's Hospital & Research Institute, Seattle, WA, 2Pediatric Nephrology, 2St. Louis Children’s Hospital, Washington University School of Medicine, St. Louis, MO

    *Purpose: BKVAN is not only a cause of acute renal allograft injury but is a recognized cause of chronic allograft disease and in some patients,…
  • 2020 American Transplant Congress

    Hyperspectral Imaging of Human Kidney Allografts

    R. Sucher1, H. Köhler2, A. Lederer1, H. M. Hau1, I. Gockel1, D. Seehofer1

    1Department of Visceral, Transplant-, Thoracic and Vascular Surgery, University Clinic Leipzig, Leipzig, Germany, 2Innovation Center for Computer Assisted Surgery, University Clinic Leipzig, Leipzig, Germany

    *Purpose: Hyperspectral imaging (HSI) is capable to deliver non-contact, non-ionizing and non-invasive quantitative diagnostic information about tissue pathology, morphology and composition, based on the spectral…
  • 2020 American Transplant Congress

    Accelerated Decline in Glomerular Density: An Unrecognized Pathologic Process after Kidney Transplantation

    A. Denic, B. H. Smith, W. D. Park, M. V. Luhman, M. P. Alexander, A. D. Rule, M. D. Stegall

    Mayo Clinic, Rochester, Rochester, MN

    *Purpose: Studies in healthy adults have shown that glomerular density slowly declines with older age (-0.5% per decade), and globally sclerotic glomeruli (GSG) slowly increase…
  • 2020 American Transplant Congress

    Kidney Cortical Wedge Biopsies for Human Organ Research: Does Anatomic Variability Impact Their Utility?

    C. M. Edwards1, J. T. Langford1, M. Reschke2, J. R. DiRito1, D. Mulligan1, D. Haakinson1, G. T. Tietjen1

    1Surgery, Yale School of Medicine, New Haven, CT, 2Biomedical Engineering, Yale University, New Haven, CT

    *Purpose: The purpose of this study is to characterize human kidney anatomic variability both within singular biopsies and between biopsy sites in order to investigate…
  • 2020 American Transplant Congress

    Computer-Assisted Cardiac Histologic Evaluation (CACHE) for Grading Cardiac Allograft Rejection

    E. Peyster1, S. ArabYarmohommadi2, A. Janowczyk2, M. Sekulic3, C. Cassol4, M. Feldman1, K. Margulies1, A. Madabhushi2

    1University of Pennsylvania, Philadelphia, PA, 2Case Western Reserve University, Cleveland, OH, 3University Hospitals Cleveland Medical Center, Cleveland, OH, 4Ohio State University, Columbus, OH

    *Purpose: Cardiac allograft rejection (CAR) is a serious concern in heart transplantation, occurring in 30-40% of patients during the first year. Endomyocardial biopsy (EMB) with…
  • 2020 American Transplant Congress

    Noninvasive Imaging of CD122+ T Cells via Immuno-PET for Detection of Acute Cellular Rejection

    A. J. Matar1, B. P. Lovasik1, D. Vanover2, L. Rotolo2, Y. Dong1, D. A. Faber1, D. V. Mathews1, W. H. Kitchens1, P. Santangelo2, A. B. Adams1

    1Surgery and Transplantation, Emory University, Atlanta, GA, 2Biomedical Engineering, Georgia Tech, Atlanta, GA

    *Purpose: Acute cellular rejection (ACR) remains a clinically important problem following organ transplantation. Clinically, suspicion of ACR is dependent upon serum laboratory values, and diagnosis…
  • 2020 American Transplant Congress

    Imaging OX40+Alloreactive T Cells Provides Early Warning of Organ Transplant Rejection

    T. Hirai1, A. Mayer2, T. W. Nobashi2, Z. Xiao2, T. Udagawa3, K. Seo4, F. Simonetta5, J. Baker5, A. Cheng3, S. S. Gambhir2, R. S. Negrin5

    1Department of Urology, Tokyo Women's Medical University, Tokyo, Japan, 2Department of Radiology, Stanford University, Stanford, CA, 3Department of Otolaryngology-Head and Neck Surgery, Stanford University, Stanford, CA, 4Division of Cardiovascular Medicine, Stanford University, Stanford, CA, 5Division of Blood and Marrow Transplantation, Stanford University, Stanford, CA

    *Purpose: Diagnosis of organ transplant rejection relies upon biopsy approaches to confirm alloreactive T cell infiltration in the graft. Immuno positron emission tomography (immunoPET) utilizing…
  • 2020 American Transplant Congress

    Multiplexed Imaging Mass Cytometry Analysis Reveals a New Role for CD68+ Macrophages in Chronic Liver Transplant Rejection

    J. Emamaullee, C. Man, J. Hoeflich, N. Ung, R. Sun, N. Matasci, J. Katz, J. Lee, S. Chopra, L. Sher, S. Asgharzadeh, O. Akbari, Y. Genyk

    University of Southern California, Los Angeles, CA

    *Purpose: Rejection continues to be an important cause of graft loss and failure post-liver transplant (LT). Recently, a novel high-resolution mass spectrometry-based technique has been…
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