Articles tagged "IgG"

2022 American Transplant Congress
Marginal Zone Phenotype B Cells Are Required for Formation of Donor-Specific IgG After Allogeneic Sensitization
M. A. Kallarakal, G. Cohen, S. M. Krummey
Department of Pathology, Johns Hopkins University, Baltimore, MD
*Purpose: The formation of allogeneic antibody directed against non-self MHC, termed donor-specific antibody (DSA), is a significant barrier to successful transplant outcomes. Pre-formed DSA limits…
2022 American Transplant Congress
Poor Prognosis of Proliferative Glomerulonephritis with Monoclonal IgG Deposits in Renal Allografts: A Retrospective Multicenter Study from China
Q. Wu¹, D. Liang¹, X. Ni¹, T. Song², X. Wu³, M. Zhang¹, J. Chen¹, D. Cheng¹, W. Jiqiu¹
¹National Clinical Research Center of Kidney Diseases, Jinling Hospital,Nanjing University Jinling School of Medicine, Nanjing, China, ²Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, China, ³Department of Urology, Henan Provincial People's Hospital; Zhengzhou University People's Hospital, Zhengzhou, China
*Purpose: To analyze the clinicopathological characteristics, treatment efficacy and prognosis of proliferative glomerulonephritis with monoclonal IgG deposits (PGNMID) in renal allografts from multi-centers in China.*Methods:…
2022 American Transplant Congress
Longitudinal Analysis of the Lung Microbiome and Immune Status in Lung Transplant Recipients
Y. Zhao, P. Zhang, Y. Su, Y. Zhu, L. Shen
Shanghai Pulmonary Hospital, Shanghai, China
*Purpose: The dynamic remodeling of lung flora structure and the association between microbial community dynamics and immune status after lung transplantation (LTx) remain unclear.*Methods: Fourteen…
2022 American Transplant Congress
The Impact of Neutralizing Antibodies on Polyomavirus Infections in Mice
D. R. Butcher, B. D. Thompson, H. K. Singh, V. Nickeleit
Pathology and Laboratory Medicine, UNC Chapel Hill School of Medicine, Chapel Hill, NC
*Purpose: Definitive polyomavirus nephropathy (PyVN) affects kidney transplants and impacts allograft function and survival. Data suggest that neutralizing PyV strain specific antibodies can attenuate and…
2022 American Transplant Congress
Dynamic Changes in Titer and Specificity Autoantibodies in Chronic Bm12 to B/6 Kidney Rejection
I. Sayin¹, D. Yin¹, D. Ghosh², M. Clark², A. Chong¹
¹Department of Surgery, University of Chicago, Chicago, IL, ²Department of Medicine, University of Chicago, Chicago, IL
*Purpose: Loss of autoreactive B cell tolerance and production of non-HLA autoantibodies have been observed in patients undergoing chronic rejection, however, how autoreactive B cells…
2022 American Transplant Congress
Specificity and Avidity of Donor MHC-Specific B Cells in Naive, Rejecting and Tolerant Mice
I. Sayin¹, S. Khiew², D. Yin¹, P. Sage³, C. B. Cavazzoni³, R. King⁴, A. Chong¹
¹Department of Surgery, University of Chicago, Chicago, IL, ²Merck, Boston, MA, ³Brigham and Women's Hospital, Boston, MA, ⁴Department of Microbiology, University of Alabama, Birmingham, AL
*Purpose: Antibody-mediated rejection is recognized as an important mediator of graft loss in the clinic, and the induction of donor-specific B cell tolerance may contribute…
2022 American Transplant Congress
Utility of Cytomegalovirus T-Cell Immunity Panel to Predict CMV Infections in Lung Transplant Recipients
R. W. Lincoln¹, B. J. Pierce¹, C. Pham¹, S. W. Yau², A. Goodarzi², J. G. Youssef², H. J. Huang²
¹Pharmacy, Houston Methodist Hospital, Houston, TX, ²Pulmonology, Houston Methodist Hospital, Houston, TX
*Purpose: Given the limited data of cytomegalovirus T-cell immunity panels (CMV TCIP) in lung transplant recipients (LTR), we sought to describe our center’s experience with…
2022 American Transplant Congress
A Novel Immunosuppressive Compound (79-6) That Targets Bcl6 Prevents the Humoral Alloresponse
R. Kraaijeveld, D. A. Hesselink, C. C. Baan
Internal medicine - Nephrology and Transplantation, Erasmus Medical Center, Rotterdam, Netherlands
*Purpose: BCL6, is a transcription factor involved in B cell activation and differentiation. BCL6-expressing B cells play a crucial role in the development and maintenance…
2021 American Transplant Congress
Prevalence and Dynamics of SARS-COV-2 IgG in Kidney Transplant Recipients
Y. Al Azzi, P. Loarte, C. Pynadath, O. Alani, L. Liriano-Ward, M. Ajaimy, R. Bartash, J. Graham, M. Le, H. Yaffe, S. Greenstein, J. Rocca, M. Kinkhabwala, E. Akalin
Montefiore Medical Center, New York, NY
*Purpose: We aimed to investigate the prevalence and dynamics of SARS-CoV-2 IgG in kidney transplant recipients in the Bronx, New York, one of the epicenters…
2021 American Transplant Congress
Measuring the Impact of Targeting FcRn-Mediated IgG Recycling on Donor-Specific Alloantibodies in a Sensitized NHP Model
M. Manook¹, W. Flores², R. Schmitz¹, Z. Fitch¹, J. Yoon¹, Y. Bae¹, B. I. Shaw¹, M. Harnois³, S. Permar³, A. Kirk¹, D. Magnani², J. Kwun¹, S. Knechtle¹
¹Duke Transplant Center, Duke University Medical Center, Durham, NC, ²Massbiologics, University of Massachusetts Medical School, Boston, MA, ³Human Vaccine Institute, Duke University Medical Center, Durham, NC
*Purpose: In transplantation, plasmapheresis and IVIg provide the mainstay of treatment directed at reducing or removing circulating donor specific antibody (DSA), yet both have limitations.…

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