Articles tagged "Hyperacute rejection"

2022 American Transplant Congress
First Report of Xenotransplantation from a Pig to Human Recipient
J. Stern¹, V. Tatapudi¹, B. Lonze¹, Z. Stewart¹, M. Mangiola¹, M. Wu¹, S. Mehta¹, E. Weldon¹, R. Dieter¹, N. Lawson¹, A. Griesemer², B. Parent¹, G. Piper¹, P. Sommer¹, S. Cawthon¹, B. Sullivan¹, N. Ali¹, R. A. Montgomery¹
¹NYU Langone Transplant Institute, New York, NY, ²CUMC, New York, NY
*Purpose: Xenotransplantation of genetically edited pig organs into human recipients can solve the global scarcity of organs for transplantation. Humans lack the α1,3-Gal glycan ubiquitously…
2019 American Transplant Congress
Evaluation Of Complement-related Factors In Tma Post-kidney Transplantation: A Retrospective Multicenter Study
N. Fujiyama¹, M. Tasaki², H. Harada³, K. Tsutahara⁴, A. Matsumoto⁵, Y. Hara⁶, M. Okumi⁷, K. Saito², Y. Watarai⁸, N. Inoue⁹, N. Wakamiya⁹, S. Satoh¹
¹Center for Kidney Disease and Transplantaion, Akita University Hospital, Akita, Japan, ²Department of Urology, Niigata University, Niigata, Japan, ³Kidney Transplant Surgery, Sapporo City General Hospital, Sapporo, Japan, ⁴Department of Urology, Osaka General Medical Center, Osaka, Japan, ⁵Department of Urology, The University of Tokyo, Tokyo, Japan, ⁶Department of Nephrolog, Shinsyu University Hospital, Shinsyu, Japan, ⁷Department of Urology, Tokyo Women’s Medical University, Tokyo, Japan, ⁸Department of Transplant Surgery, Nagoya Daini Red Cross Hospital, Nagoya, Japan, ⁹The Japanese Association for Complement Research, Osaka, Japan
*Purpose: Post-kidney transplant thrombotic microangiopathy (KT-TMA) is a poor prognostic complication that causes a high rate of graft loss. In this study, we investigated KT-TMA-associated…
2017 American Transplant Congress
Experience with the Bacterial Enzyme IdeS (IgG Endopeptidase) for Desensitization of Highly-HLA Sensitized (HS) Kidney Allograft Recipients.
S. Jordan,¹ J. Choi,¹ C. Kjellman,² L. Winstedt,² X. Zhang,⁴ S. Louie,¹ A. Kang,¹ M. Haas,³ A. Vo.¹
¹Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA; ²Hansa Medical, Lund, Sweden; ³Dept of Pathology, Cedars-Sinai Medical Center, Los Angeles, CA; ⁴HLA, Cedars-Sinai Medical Center, Los Angeles, CA
Donor specific antibodies (DSA) create an impenetrable immunologic barrier to transplantation. Current rx aimed at modification of DSAs are not effective in the most HS…
2017 American Transplant Congress
A Combination of Anti-CD40L-Ab, Rapamycin, and Donor Apoptotic Cells Prolongs Allogeneic Pancreatic Islet Survival in Sensitized Mice by Regulating Memory Responses.
A. Dangi,¹ H.-K. Kang,¹ X. Zhang,^2,3 X. Luo.^1,2,3
¹Nephrology and Hypertension, Northwestern University, Chicago, IL; ²Comprehensive Transplant Center, Northwestern University, Chicago, IL; ³Surgery, Northwestern University, Chicago, IL
Accelerated rejection of allografts has been a clinical challenge in solid organ transplantation particularly in sensitized recipients with donor-specific antibodies (DSA) and memory cell repertoires.…
2017 American Transplant Congress
Pre-Operative Desensitization for Live Donor Liver Transplantation with Strong Donor-Specific Antibodies.
M. Fujiki,¹ K. Hashimoto,¹ A. Zhang,² F. Aucejo,¹ C. Quintini,¹ T. Diago,¹ B. Eghtesad,¹ C. Miller.¹
¹General Surgery, Cleveland Clinic, Cleveland, OH; ²Allogen Laboratories, Cleveland Clinic, Cleveland, OH
Background: Presence of strong donor-specific antibodies (DSA) (MFI>4000) likely results in uncomplicated short-term outcome in whole liver transplants due to absorption of DSA by the…
2016 American Transplant Congress
Postoperative Rebound of Anti-Blood Type Antibodies and Antibody-Mediated Rejection After ABO-Incompatible Living Related Kidney Transplantation – Is Prophylactic Treatment Necessary?
H. Ishida, T. Kondo, T. Shimizu, T. Nozaki, K. Tanabe.
Urology, Tokyo Women's Medical University Hospital, Tokyo, Japan.
PURPOSE: The role of postoperative anti-ABO titers in acute rejection under our current immunosuppressive regimen remains unclear. Some institutions recommend postoperative therapeutic plasma exchange to…
2016 American Transplant Congress
Establishment of SCID Pigs Cell Lines to Prevent Immunodeficiency Using RGEN System.
D.-H. Kim,¹ J.-S. Ahn,¹ S. Hwang,² J.-W. Lee.¹
¹Functional Genomics Reaserch Center, KRIBB, Daejeon, Korea; ²Animal Biotechnology Division, RDA, Wanju-gun, Jeollabuk-do, Korea.
Severe immune disorder is the biggest problem in xenotransplantation. To overcome the the problem, producing severe combined immune deficiency (SCID) pigs which lack T cell…
2015 American Transplant Congress
Outcomes of Eculizumab (ANTI-C5) Therapy for Treatment of Refractory Antiobdy-Mediated Rejection (ABMR) and Thrombotic Microangiopathy (TMA)
P. Wongsaroj,¹ J. Choi,¹ A. Vo,¹ J. Kahwaji,¹ A. Peng,¹ R. Villicana,¹ M. Haas,² S. Jordan.¹
¹Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA; ²Pathology, Cedars-Sinai Medical Center, Los Angeles, CA.
Introduction: ABMR results from DSA binding to donor endothelium initiating the classical complement pathway. This results in the formation of terminal MAC (C5b-C9) complex and…