ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "HLA matching"

  • 2017 American Transplant Congress

    The Outcome of 0 Mismatch Kidney in Pediatric Population with High Immunologic. The Impact of Induction Therapy. An Analysis of UNOS Database.

    V. Whittaker, M. Laftavi, Z. Acun, R. Gruessner, A. Gruessner.

    Surgery, State University New York, Syracuse, NY

    Background: 0 mismatch kidneys have superior outcomes in primary transplant recipient. We performed Analysis UNOS database to determine the outcome of high PRA transplant pediatric…
  • 2017 American Transplant Congress

    Kidney Transplant Rejection Associated with DQ Eplet Mismatches.

    S. Chakola,1 P. Warner,2 N. Andeen,3 B. Najafian,3 N. Leca,1 C. Blosser.1

    1Medicine, University of Washington, Seattle, WA; 2Bloodworks Northwest, Seattle, WA; 3Pathology, University of Washington, Seattle, WA

    The presence of anti-HLA antibodies is associated with acute rejection, allograft dysfunction and earlier graft loss. HLA antibodies are recognized as being specific to these…
  • 2017 American Transplant Congress

    Graft-versus-Host Disease Following Deceased Donor Liver Transplant.

    K. Putchakayala, S. Skorupski, S. Farhan, M. Chaffins, S. Ilias, H. Pahari, K. Collins, S. Nagai, M. Abouljoud.

    Henry Ford Hospital, Detroit, MI

    We reviewed our institutional experience with graft-versus-host disease (GVHD) following orthotopic liver transplantation (OLT). All OLT from 10/1/2013-10/1/2016 were reviewed. Five cases of GVHD were…
  • 2017 American Transplant Congress

    Zero HLA Mismatch Matters in ABO Incompatible Kidney Transplant.

    T. Alhamad,1 K. Lentine,2 K. Venkatachalam,1 A. Malone,1 D. Brennan.1

    1Washington University in St. Louis, St. Louis; 2Saint Louis University, St. Louis

    Transplantation across blood group incompatibilities (ABOi) after preconditioning has emerged as an acceptable option for expanding live donor kidney transplantation (LKDT) to more patients who…
  • 2017 American Transplant Congress

    HLA Eplet Mismatches Predict DSA Formation, Graft Survival, and Re-Transplantation Rate in Pediatric Renal Transplantation.

    M. Sypek,1,2 S. Hiho,3 L. Cantwell,3 P. Hughes,2 A. Le Page,4 J. Kausman.1

    1Royal Children's Hospital, Melbourne, Australia; 2Royal Melbourne Hospital, Melbourne, Australia; 3Victorian Transplant and Immunogenetics Service, Melbourne, Australia; 4Monash Children's Hospital, Melbourne, Australia

    The potential benefits of HLA epitope based matching are greatest for pediatric recipients, however, there is little published data on the association of epitope mismatches…
  • 2017 American Transplant Congress

    HLA-C Mismatching and Humoral Alloimmune Responses in Pediatric Kidney Recipients with Subclinical Vascular Injury.

    M. Seifert, M. Yanik, V. Hauptfeld-Dolejsek, R. Mannon.

    University of Alabama at Birmingham, Birmingham, AL

    Background: Antibodies to mismatched donor HLA antigens (DSA) have been associated with poor long-term outcomes in adult kidney recipients. We recently demonstrated a high prevalence…
  • 2017 American Transplant Congress

    Effects of New KPD Histocompatibility Policy on Refusal Rate and Transplants.

    R. Leishman,1 M. Aeder,2 M. Leffell,3 C. Murphey,4 N. Reinsmoen,5 S. Saidman,6 T. Sandholm,7 A. Toll,1 A. Harper,1 N. Turgeon.8

    1UNOS, Richmond, VA; 2Univ Hosp Med Ctr, Cleveland, OH; 3Johns Hopkins Univ, Baltimore, MD; 4SW Immunodiagnostics, San Antonio, TX; 5Cedars-Sinai Health, Los Angeles, CA; 6Mass Gen Hosp, Boston, MA; 7Carnegie Mellon Univ, Pittsburgh, PA; 8Emory Univ, Atlanta, GA

    Background: Transplant centers commonly refuse kidney paired donation (KPD) match offers due to unacceptable crossmatch (XM). To reduce XM refusals a new OPTN KPD histocompatibility…
  • 2017 American Transplant Congress

    The New Kidney Allocation System in France Meets it's Targets: Improving Age and HLA DR-QD Matching for Young Adults.

    C. Jacquelinet, B. Audry, F. Bayer, M. Macher.

    Direction Medicale et Scientifique, Agence de la Biomedecine, Saint-Denis, France

    A new KAS was implemented in France as of February 2015, resulting from an intensive 3 yrs-simulation work in interaction with KTx advisory committee and…
  • 2017 American Transplant Congress

    Development of De Novo Donor Specific Antibodies (dnDSAs) Not the Presence of Pre-Transplant Donor Specific Antibodies (Pre-DSAs) Increase Rejection Risk in Crossmatch Negative Kidney Transplant Recipients.

    H. Khamash, L. Archambault, M. Buras, H. Kosiorek, M. Pando, K. Reddy, B. Kaplan, R. Heilman.

    Mayo Clinic Arizona, Phoenix, AZ

    Aim: Study the impact of Pre-DSAs on allograft outcomes in crossmatch negative kidney transplant recipients.Methods: Single center retrospective analysis of characteristics and outcomes of kidney…
  • 2017 American Transplant Congress

    A Novel Computational HLA Matching Algorithm for Improving Donor-Recipient Histocompatibility and Graft Outcomes After Kidney Transplantation.

    V. Kosmoliaptsis,1 D. Mallon,1 S. Fuggle,2 R. Johnson,2 C. Watson,1 J. Bradley,1 C. Taylor.1

    1Department of Surgery, University of Cambridge, Cambridge, United Kingdom; 2NHS Blood and Transplant, Bristol, United Kingdom

    Introduction: Human Leukocyte Antigen (HLA) matching is a central objective of kidney allocation policies, but current assessment of histocompatibility is inadequate. Building on our previous…
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