Articles tagged "HLA matching"

2017 American Transplant Congress
Effects of New KPD Histocompatibility Policy on Refusal Rate and Transplants.
R. Leishman,¹ M. Aeder,² M. Leffell,³ C. Murphey,⁴ N. Reinsmoen,⁵ S. Saidman,⁶ T. Sandholm,⁷ A. Toll,¹ A. Harper,¹ N. Turgeon.⁸
¹UNOS, Richmond, VA; ²Univ Hosp Med Ctr, Cleveland, OH; ³Johns Hopkins Univ, Baltimore, MD; ⁴SW Immunodiagnostics, San Antonio, TX; ⁵Cedars-Sinai Health, Los Angeles, CA; ⁶Mass Gen Hosp, Boston, MA; ⁷Carnegie Mellon Univ, Pittsburgh, PA; ⁸Emory Univ, Atlanta, GA
Background: Transplant centers commonly refuse kidney paired donation (KPD) match offers due to unacceptable crossmatch (XM). To reduce XM refusals a new OPTN KPD histocompatibility…
2017 American Transplant Congress
The New Kidney Allocation System in France Meets it's Targets: Improving Age and HLA DR-QD Matching for Young Adults.
C. Jacquelinet, B. Audry, F. Bayer, M. Macher.
Direction Medicale et Scientifique, Agence de la Biomedecine, Saint-Denis, France
A new KAS was implemented in France as of February 2015, resulting from an intensive 3 yrs-simulation work in interaction with KTx advisory committee and…
2017 American Transplant Congress
Development of De Novo Donor Specific Antibodies (dnDSAs) Not the Presence of Pre-Transplant Donor Specific Antibodies (Pre-DSAs) Increase Rejection Risk in Crossmatch Negative Kidney Transplant Recipients.
H. Khamash, L. Archambault, M. Buras, H. Kosiorek, M. Pando, K. Reddy, B. Kaplan, R. Heilman.
Mayo Clinic Arizona, Phoenix, AZ
Aim: Study the impact of Pre-DSAs on allograft outcomes in crossmatch negative kidney transplant recipients.Methods: Single center retrospective analysis of characteristics and outcomes of kidney…
2017 American Transplant Congress
A Novel Computational HLA Matching Algorithm for Improving Donor-Recipient Histocompatibility and Graft Outcomes After Kidney Transplantation.
V. Kosmoliaptsis,¹ D. Mallon,¹ S. Fuggle,² R. Johnson,² C. Watson,¹ J. Bradley,¹ C. Taylor.¹
¹Department of Surgery, University of Cambridge, Cambridge, United Kingdom; ²NHS Blood and Transplant, Bristol, United Kingdom
Introduction: Human Leukocyte Antigen (HLA) matching is a central objective of kidney allocation policies, but current assessment of histocompatibility is inadequate. Building on our previous…
2016 American Transplant Congress
Zero and One Mismathing for HLA DR10,14,16 Produces Increased Kidney Graft Survival.
J. Cicciarelli,^1,2 Y. Cho,² M. Altrich,¹ N. Kasahara,^1,3 N. Lemp.¹
¹Viracor-IBT HLA Lab, Viracor-IBT Laboratories, Los Angeles, CA; ²USC Keck School of Medicine, Los Angeles, CA; ³University of Miami, Miami, FL.
Aims: HLA DR matching has shown measureable significant effects in kidney graft survival. Part and parcel of this association is the HLA Class II allele…
2016 American Transplant Congress
Do Highly Sensitized Recipients Benefit from the Immunological Advantages of Zero Mismatched (0MM) Deceased Donors (DD) Kidney Allografts?
N. Elfadawy,¹ S. Flechner,² J. Schold.²
¹Internal Medicine, Case Western Reserve University, Cleveland, OH; ²Glickman urological and kidney institute, Cleveland Clinic, Cleveland, OH.
HLA 0MM DD transplants have superior outcomes compared with outcomes for grafts with ≥1 HLA mismatches, but when past reports analyzed 0MM outcomes in DD,…
2016 American Transplant Congress
Complex Constellation of HLA Antibodies Contributes to Decreasing Trend of Transplant Rate in Candidates with 100% CPRA.
R. Rajalingam, D. Hyon Gae, D. Kopchaliiska, O. Buenaventura, K. Cunniffe, G. Da Gente, J. Roberts.
Immunogenetics and Transplantation Laboratory; Department of Surgery, University of California-San Francisco, San Francisco, CA.
The key component of new KAS is offering an increased priority for sensitized candidates. While transplants (tx) have increased six-fold for recipients with a CPRA…
2016 American Transplant Congress
Exome Sequencing and HLA-Independent Prediction of Long-Term Kidney Allograft Function.
L. Mesnard,^1,3,6 T. Muthukumar,^2,9 M. Burbach,² C. Li,² H. Shang,⁴ D. Dadhania,^2,3 J. Lee,^2,3 V. Sharma,² J. Xiang,⁴ M. Carmagnat,⁵ C. Suberbielle,⁵ N. Ouali,⁶ E. Rondeau,^6,1 J. Friedewald,⁸ M. Abecassis,⁷ M. Suthanthiran,^2,9 F. Campagne.³
¹UMR1155, INSERM, Paris, France; ²Division of Nephrology and Hypertension, New York Presbyterian Hospital, New York; ³Department of Physiology and Biophysics, The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, New York, NY; ⁴Genomics Core Facility, Weill Cornell Medical College, New York, NY; ⁵Laboratoire d'histocompatibilité Hôpital Saint Louis, APHP, Paris, France; ⁶Service des Urgences Néphrologiques et Transplantation Rénale, APHP, Paris, France; ⁷Comprehensive Transplant Center, Northwestern University Feinberg School of Medicine, Chicago, IL; ⁸Northwestern University Feinberg School of Medicine, Chicago, IL; ⁹Department of Transplantation Medicine, Weill Cornell Medical College, New York, NY.
Current strategies to improve graft outcome following kidney transplantation consider information at the HLA loci. We asked whether information outside of the HLA loci can…
2016 American Transplant Congress
Donor Specific Antibody Used to Predict Crossmatch Results: A Clinically Useful Algorithm Derived from the College of American Pathologists Survey.
S. Wrenn,¹ D.-S. Hain,² S. Harm,² S. Hillyard,² D. Shah,² P. Hammond,² C. Marroquin,¹ M. Fung.²
¹Transplant Surgery, University of Vermont Medical Center, Burlington, VT; ²Pathology, University of Vermont Medical Center, Burlington, VT.
Purpose: While there are multiple modalities to perform a preoperative crossmatch for organ transplant surgery, the cytotoxic crossmatch remains the gold standard for detection of…
2016 American Transplant Congress
Improving Kidney Allocation System with Higher Resolution.
M. Cusick, J. Friedewald, K. Haarberg, J. Leventhal, A. Tambur.
Northwestern University, Chicago, IL.
Purpose: The new kidney allocation system (KAS) was implemented to help identify compatible donors for the most highly sensitized patients. Our experience, as well as…