2019 American Transplant Congress
Relationship between HLA-DPB1 Gene Expression in Pre-Implantation Kidney Biopsies, Rs9277534 Polymorphism, and Late Graft Function
*Purpose: A previous gene expression microarray study in pre-implantation biopsies (PIB) from kidneys of adult deceased donors (D) showed association between high class II HLA…2019 American Transplant Congress
Impact of HLA Mismatches and Cytomegalovirus Seropositivity on Outcomes Following Heart Transplantation
Division of Cardiology/ JC Walter Jr. Transplant Center, Houston Methodist Hospital, Houston, TX
*Purpose: Cytomegalovirus (CMV) infection is associated with the development of cardiac allograft vasculopathy (CAV). CAV is one of the leading causes of death and graft…2019 American Transplant Congress
Influence Of HLA-DR Mismatches On Long Term Outcomes Following Heart Transplantation
Division of Cardiology/ JC Walter Jr. Transplant Center, Houston Methodist Hospital, Houston, TX
*Purpose: In the field of kidney transplantation, there is strong support for the beneficial effect of minimizing donor-recipient HLA incompatibility, and HLA-DR matching in particular…2019 American Transplant Congress
Effect of HLA Mismatch on Recurrence and Graft Loss in Living versus Deceased Kidney Transplant Recipients with IgA Nephropathy
Johns Hopkins School of Medicine, Baltimore, MD
*Purpose: A registry based study from Australia and New Zealand reported increased risk of recurrent IgA nephropathy (IgAN) in zero-HLA-mismatched living donor kidney transplant (LDKT)…2019 American Transplant Congress
Emergence of Anti-HLA Antibodies after Catch-Up Vaccinations in Pediatric Kidney Transplant Candidates
*Purpose: Evaluate anti-HLA antibody (Ab) emergence after catch-up vaccinations in pediatric kidney transplant candidates (PKTC).*Methods: A single center retrospective review of PKTC 25% from baseline,…2019 American Transplant Congress
Kidney Transplantation in Older Recipients with HLA-DR Mismatch: Impact of Induction Type on Outcomes
*Purpose: In kidney transplantation, donor-recipient HLA-DR mismatch signals high immunologic risk and can result in poor transplant outcomes. Older kidney transplant recipients (KTRs) are more…2019 American Transplant Congress
Successful Kidney Transplantation of Highly Sensitized Candidates across Positive Cross Match and Strong Donor-Specific HLA-DP Antibodies without Desensitization
*Purpose: Over 50% of kidney transplant (Ktx) candidates with 100% CPRA display HLA-DP antibodies, which impair the chances of finding a compatible deceased donor (DD)…2019 American Transplant Congress
High HLA-DQ Epitope Mismatch Load and Low Tacrolimus Level Are Associated with Development of De Novo Donor Specific Antibody
*Purpose: Purpose of our study is to evaluate the clinical significance of HLA class II epitope mismatch loads for the development of de novo DSA…2019 American Transplant Congress
Computational Assessment of T-cell and B-cell Allorecognition to Predict Donor HLA Immunogenicity
*Purpose: Donor-specific alloantibody (DSA) development after solid-organ transplantation is a major cause of graft loss, and limits future transplant options. We have previously shown that…2019 American Transplant Congress
Correlation of Crossmatch Predictions with Actual Results and Clinical Outcomes
1Vanderbilt University Medical Center, Nashville, TN, 2Dialysis Clinic, Inc, Nashville, TN
*Purpose: Flow cytometry crossmatching (FXM) is recognized as a valuable tool to assess immunological risk prior to renal transplantation. The increased resolution in HLA typing…
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