2019 American Transplant Congress
Successful Kidney Transplantation of Highly Sensitized Candidates across Positive Cross Match and Strong Donor-Specific HLA-DP Antibodies without Desensitization
*Purpose: Over 50% of kidney transplant (Ktx) candidates with 100% CPRA display HLA-DP antibodies, which impair the chances of finding a compatible deceased donor (DD)…2019 American Transplant Congress
High HLA-DQ Epitope Mismatch Load and Low Tacrolimus Level Are Associated with Development of De Novo Donor Specific Antibody
*Purpose: Purpose of our study is to evaluate the clinical significance of HLA class II epitope mismatch loads for the development of de novo DSA…2019 American Transplant Congress
Computational Assessment of T-cell and B-cell Allorecognition to Predict Donor HLA Immunogenicity
*Purpose: Donor-specific alloantibody (DSA) development after solid-organ transplantation is a major cause of graft loss, and limits future transplant options. We have previously shown that…2019 American Transplant Congress
Correlation of Crossmatch Predictions with Actual Results and Clinical Outcomes
1Vanderbilt University Medical Center, Nashville, TN, 2Dialysis Clinic, Inc, Nashville, TN
*Purpose: Flow cytometry crossmatching (FXM) is recognized as a valuable tool to assess immunological risk prior to renal transplantation. The increased resolution in HLA typing…2019 American Transplant Congress
Predictors and Outcomes of Acute Graft-versus-Host Disease after Liver Transplant
*Purpose: Graft-versus-Host Disease (GVHD) is a rare complication of liver transplant (LT) that has an estimated incidence of 0.1%-2% per year and is associated with…2019 American Transplant Congress
Development of a Recurrence Risk Score in IgA Nephropathy after Kidney Transplantation: Role of Recipient Age and HLA-B Mismatch
*Purpose: Recurrence of IgA nephropathy is an important and growing cause of kidney allograft dysfunction. The purpose of this observational retrospective study was to characterize…2019 American Transplant Congress
Comparative Analysis of Belatacept and Mycophenolate Monotherapy-Based Regimens for HLA Identical Living Donor Kidney Transplantation
Univ. of Cincinnati, Cincinnati, OH
*Purpose: HLA identical (HLA ID) living donor kidney transplants (KTx) provide long-term survival with substantially reduced rejection risk; aspects that can be exploited in designing…2019 American Transplant Congress
Severe Acute Rejection In Human Leukocyte Antigen Identical Renal Transplants: Reviving Mixed Lymphocyte Culture
*Purpose: Human leukocyte antigen-identical renal transplants among siblings account for a minority of all renal transplants, but have excellent long-term outcomes due to very minimal…2019 American Transplant Congress
Transplant Nephrologist
*Purpose: Matching rates of very highly sensitized patients with cPRA of 91 - 100% (VHSP) and blood type O recipients of ABO incompatible donors (ABO…2019 American Transplant Congress
Specific Donor/Recipient HLA Disparities are Associated with Better Long-Term Kidney Allograft Survival among 4-, 5-, and 6-HLA (A/B/DR)-Mismatched Pairs
University of Toledo, Toledo, OH
*Purpose: The vast majority of deceased donor kidneys are allocated without any consideration for the HLA disparities, which may improve or worsen the survival the…
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