Articles tagged "HLA matching"

2019 American Transplant Congress
Emergence of Anti-HLA Antibodies after Catch-Up Vaccinations in Pediatric Kidney Transplant Candidates
H. Sweiss¹, J. Lyons¹, D. Ranch², K. Hitchman², E. Kincaide¹, B. Crowther¹
¹University Health System, The University of Texas at Austin, College of Pharmacy, Pharmacotherapy Division, Austin, TX, The University of Texas Health Science Center at San Antonio, San Antonio, TX, ²University Health System, The University of Texas Health Science Center at San Antonio, San Antonio, TX
*Purpose: Evaluate anti-HLA antibody (Ab) emergence after catch-up vaccinations in pediatric kidney transplant candidates (PKTC).*Methods: A single center retrospective review of PKTC 25% from baseline,…
2019 American Transplant Congress
Kidney Transplantation in Older Recipients with HLA-DR Mismatch: Impact of Induction Type on Outcomes
K. K. Sureshkumar¹, N. L. Thai², B. Chopra¹
¹Nephrology and Hypertension, Allegheny General Hospital, Pittsburgh, PA, ²Abdominal Transplantation, Allegheny General Hospital, Pittsburgh, PA
*Purpose: In kidney transplantation, donor-recipient HLA-DR mismatch signals high immunologic risk and can result in poor transplant outcomes. Older kidney transplant recipients (KTRs) are more…
2019 American Transplant Congress
Successful Kidney Transplantation of Highly Sensitized Candidates across Positive Cross Match and Strong Donor-Specific HLA-DP Antibodies without Desensitization
R. Rajalingam¹, D. D. Gae², Z. G. Laszik³, M. M. Tavakol⁴, A. B. Webber⁵, K. Cunniffe², G. da Gente², R. Hirose⁴, G. Roll⁴, C. E. Freise⁴, J. P. Roberts⁴
¹Immunogenetics and Transplantation Laboratory (ITL), San Francisco, CA, ²Department of Surgery, Immunogenetics and Transplantation Laboratory (ITL), San Francisco, CA, ³Department of Pathology, University of California San Francisco, San Francisco, CA, ⁴Department of Surgery, University of California San Francisco, San Francisco, CA, ⁵Department of Medicine, University of California San Francisco, San Francisco, CA
*Purpose: Over 50% of kidney transplant (Ktx) candidates with 100% CPRA display HLA-DP antibodies, which impair the chances of finding a compatible deceased donor (DD)…
2019 American Transplant Congress
High HLA-DQ Epitope Mismatch Load and Low Tacrolimus Level Are Associated with Development of De Novo Donor Specific Antibody
D. Lee¹, B. Kim², J. Kim³, I. Kim⁴, M. Jeon⁵, J. Ahn¹, S. Choi⁶
¹Nephrology, Maryknoll Medical Center, Busan 48972, Korea, Republic of, ²Laboratory Medicine, Maryknoll Medical Center, Busan 48972, Korea, Republic of, ³Surgery, Maryknoll Medical Center, Busan 48972, Korea, Republic of, ⁴Urology, Maryknoll Medical Center, Busan 48972, Korea, Republic of, ⁵Pathology, Maryknoll Medical Center, Busan 48972, Korea, Republic of, ⁶Transplantation Center, Coordinator : Nurse, Maryknoll Medical Center, Busan 48972, Korea, Republic of
*Purpose: Purpose of our study is to evaluate the clinical significance of HLA class II epitope mismatch loads for the development of de novo DSA…
2019 American Transplant Congress
Computational Assessment of T-cell and B-cell Allorecognition to Predict Donor HLA Immunogenicity
H. C. Copley¹, M. Elango¹, V. Kosmoliaptsis²
¹Department of Surgery, University of Cambridge and NIHR Cambridge Biomedical Research Centre, Cambridge University Hospital, Cambridge, United Kingdom, ²University of Cambridge and NIHR Cambridge Biomedical Research Centre, Cambridge University Hospital & NIHR Blood and Transplant Research Unit in Organ Donation and Transplantation at the University of Cambridge, Cambridge, UK., Cambridge, United Kingdom
*Purpose: Donor-specific alloantibody (DSA) development after solid-organ transplantation is a major cause of graft loss, and limits future transplant options. We have previously shown that…
2019 American Transplant Congress
Correlation of Crossmatch Predictions with Actual Results and Clinical Outcomes
R. Forbes¹, B. Concepcion¹, S. Fossey²
¹Vanderbilt University Medical Center, Nashville, TN, ²Dialysis Clinic, Inc, Nashville, TN
*Purpose: Flow cytometry crossmatching (FXM) is recognized as a valuable tool to assess immunological risk prior to renal transplantation. The increased resolution in HLA typing…
2019 American Transplant Congress
Predictors and Outcomes of Acute Graft-versus-Host Disease after Liver Transplant
A. Caines¹, S. Nagai², R. Salgia¹
¹Gastroenterology and Hepatology, Henry Ford Health System, Detroit, MI, ²Transplant Surgery, Henry Ford Health System, Detroit, MI
*Purpose: Graft-versus-Host Disease (GVHD) is a rare complication of liver transplant (LT) that has an estimated incidence of 0.1%-2% per year and is associated with…
2019 American Transplant Congress
Development of a Recurrence Risk Score in IgA Nephropathy after Kidney Transplantation: Role of Recipient Age and HLA-B Mismatch
L. M. Rodas Marin¹, E. Ruiz², A. García³, M. Blasco¹, P. Ventura¹, E. de Soussa¹, O. Viñas⁴, F. Diekmann¹, L. Quintana¹
¹Nephrology and Renal Trasplantation, Hospital Clinic, Barcelona, Spain, ²Immunology, Hospital Clinic, Barcelona, Spain, ³Pathology, Hospital Clinic, Barcelona, Spain, ⁴Inmunology, Hospital Clinic, Barcelona, Spain
*Purpose: Recurrence of IgA nephropathy is an important and growing cause of kidney allograft dysfunction. The purpose of this observational retrospective study was to characterize…
2019 American Transplant Congress
Comparative Analysis of Belatacept and Mycophenolate Monotherapy-Based Regimens for HLA Identical Living Donor Kidney Transplantation
M. Yamada, K. Meganathan, A. Shields, P. Brailey, S. Tremblay, A. Govil, R. R. Alloway, S. Shah, E. S. Woodle, B. G. Abu Jawdeh
Univ. of Cincinnati, Cincinnati, OH
*Purpose: HLA identical (HLA ID) living donor kidney transplants (KTx) provide long-term survival with substantially reduced rejection risk; aspects that can be exploited in designing…
2019 American Transplant Congress
Severe Acute Rejection In Human Leukocyte Antigen Identical Renal Transplants: Reviving Mixed Lymphocyte Culture
P. Rajendran¹, M. Cusick², S. Dhingra³, B. Murthy¹
¹Baylor College of Medicine, Houston, TX, ²Division of Abdominal Transplantation, Baylor College of Medicine, Houston, TX, ³Pathology, Baylor College of Medicine, Houston, TX
*Purpose: Human leukocyte antigen-identical renal transplants among siblings account for a minority of all renal transplants, but have excellent long-term outcomes due to very minimal…

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