Articles tagged "HLA matching"

2015 American Transplant Congress
Repeat Donor HLA Mismatch Antigens and Kidney Transplant Outcome
P. Lokhandwala,¹ M. Wang,² Z. Kadry,³ R. Shah,³ A. Jain,³ J. Gaspari,¹ N. Ghahramani,⁴ C. Abendroth,¹ H. Shike.¹
¹Pathology, Penn State Hershey Medical Center, Hershey, PA; ²Public Health Sciences, Penn State College of Medicine, Hershey; ³Transplant Surgery, PSHMC, Hershey; ⁴Nephrology, PSHMC, Hershey.
Background: Historically, poorer outcome has been reported in kidney re-transplant patients with repeat HLA mismatch antigens. Transplant practice has evolved. Risk of repeat mismatch antigen…
2015 American Transplant Congress
DQB1 Epitope Matching Predicts the Development of De Novo DSA and Antibody Mediated Rejection
M. Willicombe,¹ M. Blow,² P. Brookes,² E. Santos,² D. Taube.¹
¹Imperial College Kidney and Transplant Centre, Hammersmith Hospital, London, United Kingdom; ²H&I, Hammersmith Hospital, London, United Kingdom.
HLA DQ antibodies are the commonest de novo [DN] DSA specificity seen post renal transplantation. Their presence is associated with antibody mediated injury and allograft…
2015 American Transplant Congress
Graft-Versus-Host Disease After Orthotopic Liver Transplantation: Multivariate Analysis of Risk Factors
M. Elfeki, P. Genco, S. Pungpapong, J. Nguyen, D. Harnois.
Transplantation, Mayo Clinic, Jacksonville, FL; Laboratory Medicine and Pathology, Mayo Clinic, Jacksonville, FL.
Introduction:Acute graft versus host disease (GVHD) is a rare fatal complication following orthotopic liver transplantation (OLT). It involves activation of donor T lymphocytes by antigen…
2015 American Transplant Congress
The Synergistic Effect of Class II HLA Epitope-Mismatch and Non-Adherence on Acute Rejection and Graft Survival
C. Wiebe,^1,2 T. Nevins,³ W. Robiner,^3,4 W. Thomas,⁵ A. Matas,⁶ P. Nickerson.^1,2,8
¹Medicine, University of Manitoba, Winnipeg, MB, Canada; ²Transplant Immunology, Diagnostic Services of Manitoba, Winnipeg, MB, Canada; ³Pediatrics, University of Minnesota, Minneapolis, MN; ⁴Medicine, University of Minnesota, Minneapolis, MN; ⁵Public Health, University of Minnesota, Minneapolis, MN; ⁶Surgery, University of Minnesota, Minneapolis, MN; ⁷Immunology, University of Manitoba, Winnipeg, MB, Canada.
Predicting long-term outcomes in renal transplant recipients is essential to optimize medical therapy and determine the frequency of post-transplant pathologic and serologic monitoring. Non-adherence and…
2015 American Transplant Congress
Highly Accurate High-Resolution HLA Imputation Using Dense Genotyping Data
B. Keating,¹ Y. Li,¹ T. Guettouche,² K. Olthoff,¹ A. Shaked.¹
¹Surgery (Division of Transplantation), University of Pennsylvania, Philadelphia, PA; ²Genetics, Children's Hospital of Philadelphia, Philadelphia, PA.
HLA similarity between donors (D) and recipients (R) of solid organ transplantation (SOT) plays a central role in determining the risk of rejection or graft-versus-host…
2015 American Transplant Congress
HLA Matching Affects Patient Survival, Graft Survival, and Incidence of Rejection Episodes in Largest Analysis to Date
J. Weiner, Z. Cui, S. Mohan, E. Verna, A. Griesemer, J. Emond.
Columbia Center for Liver Disease and Transplantation, New York Presbyterian-Columbia University Medical Center, New York, NY.
Introduction: Though human leukocyte antigen (HLA) matching between donor and recipient affects both graft and patient survival after kidney and heart transplantation, prior analysis has…
2015 American Transplant Congress
A Single Centre Experience With the Living Donor Kidney Sharing Scheme: More Is Better!
K. Thomas, H. Crawshaw, S. Sinha, P. Mason, P. Harden, C. Winnearls, E. Sharples, S. Reddy, M. Sullivan, J. Gilbert, I. Quiroga, R. Ploeg, A. Vaidya, P. Friend.
Oxford Transplant Centre, Oxford University Hospitals, Oxford, Berkshire, United Kingdom.
Introduction: The living donor kidney sharing scheme was introduced in the UK to expand the donor pool. In this study we have reviewed our experience…
2015 American Transplant Congress
Do Induction Therapy, Patient-Level and Post-Operative Factors Impact Outcomes in Moderate to High Immunologic Risk Simultaneous Kidney-Pancreas Transplantation in the Era of Stringent HLA Cross-Matching?
V. Rohan, D. Taber, D. Taraskiewicz, S. Nadig, J. Mcgillicuddy, K. Chavin, P. Baliga, C. Bratton.
MUSC, Charleston, SC.
Background: Simultaneous kidney and pancreas transplantation (SPK) is a lifesaving procedure for patients with diabetes mellitus. The success of SPK is dependent upon minimization of…