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Articles tagged "HLA matching"

  • 2015 American Transplant Congress

    Impact of Pretransplant Pregnancy On Immunization and Immunologic Outcome in Kidney Transplantation

    O. Staeck,1 D. Khadzhynov,1 S. Kreimer,1 E. Rajakangas,1 C. Schönemann,2 N. Lachmann,2 K. Budde,1 F. Halleck.1

    1Nephrology, Charité Universitätsmedizin, Berlin, Germany; 2Zentrum für Transfusionsmedizin, Charité Universitätsmedizin, Berlin, Germany.

    BACKGROUND:The detailed impact of pretransplant pregnancy on HLA alloimmunization and outcome after kidney transplantation is so far not well known.PATIENTS AND METHODS:A retrospective single center…
  • 2015 American Transplant Congress

    HLA-Cw Mismatches Are Not Associated With Worse Graft Outcomes After Kidney Transplantation Even in High Levels of Antigen Expression

    M. Askar,1 N. Elfadawy,1,2 S. Flechner,1 K. Abu-Elmagd,1 J. Fung,1 J. Schold.1

    1Cleveland Clinic, Cleveland; 2University of Alexandria, Alexandria, Egypt.

    The HLA-Cw antigens are distinct in having relatively lower expression on the cell surface compared to the other HLA class I loci. Higher HLA Cw…
  • 2015 American Transplant Congress

    Human Leukocyte Antigen Mismatch and Steroid Maintenace in Kidney Transplantation

    K. Sureshkumar, R. Marcus, B. Chopra.

    Nephrology and Hypertension, Allegheny General Hospital, Pittsburgh, PA.

    Kidney transplant recipients (KTRs) with zero/minimal HLA mismatches against their donors enjoy superior long term outcomes related to diminished immune response of the recipient against…
  • 2015 American Transplant Congress

    “Unexpected” Positive Crossmatchs in Zero-HLA-A-B-DR Mismatched or HLA-DR-Matched Organs

    K. Haarberg,1 M. Cusick,1 M. Abecassis,1 A. Jaramillo,2 B. Kaplan,3 A. Tambur.1

    1Transplant Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL; 2Gift of Hope Organ and Tissue Donor Network, Itasca, IL; 3Center for Transplantation, University of Kansas Medical Center, Kansas City, KS.

    Deceased donor kidney allocation is currently prioritized by HLA-A,-B and-DR serologic matching, which disregards both specificity at the allele level, and the contributions of HLA-C,-DQ,…
  • 2015 American Transplant Congress

    The Differential Effect of HLA-DQ Mismatching on Renal Allograft Survival in Zero HLA-A,B,DR Mismatched Deceased Donor Transplants

    M. Casey,1 X. Wen,1 S. Rehman,1 A. Santos,1 S. Goldstein,1 K. Andreoni,1 B. Kaplan,2 K. Womer.1

    1University of Florida, Gainesville; 2University of Kansas, Kansas City.

    The role of HLA-DQ matching in renal graft survival is not well understood and difficult to interpret in the presence of other HLA antigen mismatches.…
  • 2015 American Transplant Congress

    Repeat Donor HLA Mismatch Antigens and Kidney Transplant Outcome

    P. Lokhandwala,1 M. Wang,2 Z. Kadry,3 R. Shah,3 A. Jain,3 J. Gaspari,1 N. Ghahramani,4 C. Abendroth,1 H. Shike.1

    1Pathology, Penn State Hershey Medical Center, Hershey, PA; 2Public Health Sciences, Penn State College of Medicine, Hershey; 3Transplant Surgery, PSHMC, Hershey; 4Nephrology, PSHMC, Hershey.

    Background: Historically, poorer outcome has been reported in kidney re-transplant patients with repeat HLA mismatch antigens. Transplant practice has evolved. Risk of repeat mismatch antigen…
  • 2015 American Transplant Congress

    DQB1 Epitope Matching Predicts the Development of De Novo DSA and Antibody Mediated Rejection

    M. Willicombe,1 M. Blow,2 P. Brookes,2 E. Santos,2 D. Taube.1

    1Imperial College Kidney and Transplant Centre, Hammersmith Hospital, London, United Kingdom; 2H&I, Hammersmith Hospital, London, United Kingdom.

    HLA DQ antibodies are the commonest de novo [DN] DSA specificity seen post renal transplantation. Their presence is associated with antibody mediated injury and allograft…
  • 2015 American Transplant Congress

    Graft-Versus-Host Disease After Orthotopic Liver Transplantation: Multivariate Analysis of Risk Factors

    M. Elfeki, P. Genco, S. Pungpapong, J. Nguyen, D. Harnois.

    Transplantation, Mayo Clinic, Jacksonville, FL; Laboratory Medicine and Pathology, Mayo Clinic, Jacksonville, FL.

    Introduction:Acute graft versus host disease (GVHD) is a rare fatal complication following orthotopic liver transplantation (OLT). It involves activation of donor T lymphocytes by antigen…
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