Articles tagged "HLA matching"

2016 American Transplant Congress
Exome Sequencing and HLA-Independent Prediction of Long-Term Kidney Allograft Function.
L. Mesnard,^1,3,6 T. Muthukumar,^2,9 M. Burbach,² C. Li,² H. Shang,⁴ D. Dadhania,^2,3 J. Lee,^2,3 V. Sharma,² J. Xiang,⁴ M. Carmagnat,⁵ C. Suberbielle,⁵ N. Ouali,⁶ E. Rondeau,^6,1 J. Friedewald,⁸ M. Abecassis,⁷ M. Suthanthiran,^2,9 F. Campagne.³
¹UMR1155, INSERM, Paris, France; ²Division of Nephrology and Hypertension, New York Presbyterian Hospital, New York; ³Department of Physiology and Biophysics, The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, New York, NY; ⁴Genomics Core Facility, Weill Cornell Medical College, New York, NY; ⁵Laboratoire d'histocompatibilité Hôpital Saint Louis, APHP, Paris, France; ⁶Service des Urgences Néphrologiques et Transplantation Rénale, APHP, Paris, France; ⁷Comprehensive Transplant Center, Northwestern University Feinberg School of Medicine, Chicago, IL; ⁸Northwestern University Feinberg School of Medicine, Chicago, IL; ⁹Department of Transplantation Medicine, Weill Cornell Medical College, New York, NY.
Current strategies to improve graft outcome following kidney transplantation consider information at the HLA loci. We asked whether information outside of the HLA loci can…
2016 American Transplant Congress
Donor Specific Antibody Used to Predict Crossmatch Results: A Clinically Useful Algorithm Derived from the College of American Pathologists Survey.
S. Wrenn,¹ D.-S. Hain,² S. Harm,² S. Hillyard,² D. Shah,² P. Hammond,² C. Marroquin,¹ M. Fung.²
¹Transplant Surgery, University of Vermont Medical Center, Burlington, VT; ²Pathology, University of Vermont Medical Center, Burlington, VT.
Purpose: While there are multiple modalities to perform a preoperative crossmatch for organ transplant surgery, the cytotoxic crossmatch remains the gold standard for detection of…
2016 American Transplant Congress
Improving Kidney Allocation System with Higher Resolution.
M. Cusick, J. Friedewald, K. Haarberg, J. Leventhal, A. Tambur.
Northwestern University, Chicago, IL.
Purpose: The new kidney allocation system (KAS) was implemented to help identify compatible donors for the most highly sensitized patients. Our experience, as well as…
2016 American Transplant Congress
Presence of Highly Immunogenic Mismatch Eplets Is Associated with Development of Chronic Active Antibody-Mediated Rejection: A First Report from Japan.
D. Iwami, K. Morita, H. Sasaki, H. Higuchi, Y. Takada, N. Shinohara.
Urology, Hokkaido University Hospital, Sapporo, Hokkaido, Japan.
Backgrounds: De novo donor specific antibody (dnDSA) correlates with chronic active antibody-mediated rejection (CAAMR), a major leading cause of graft loss. It will be a…
2016 American Transplant Congress
Protective Impact of the Kidney in SPK Transplants – Mechanisms for Improved Outcomes Compared with Solitary Transplants.
E. Finger, T. Dunn, A. Kukla, V. Kirchner, R. Kandaswamy.
Surgery, University of Minnesota, Minneapolis, MN.
Purpose: Outcomes for SPK txps are superior to solitary pancreas txps. The basis for this difference is unknown. We sought to identify the biologic mechanism…
2015 American Transplant Congress
The Synergistic Effect of Class II HLA Epitope-Mismatch and Non-Adherence on Acute Rejection and Graft Survival
C. Wiebe,^1,2 T. Nevins,³ W. Robiner,^3,4 W. Thomas,⁵ A. Matas,⁶ P. Nickerson.^1,2,8
¹Medicine, University of Manitoba, Winnipeg, MB, Canada; ²Transplant Immunology, Diagnostic Services of Manitoba, Winnipeg, MB, Canada; ³Pediatrics, University of Minnesota, Minneapolis, MN; ⁴Medicine, University of Minnesota, Minneapolis, MN; ⁵Public Health, University of Minnesota, Minneapolis, MN; ⁶Surgery, University of Minnesota, Minneapolis, MN; ⁷Immunology, University of Manitoba, Winnipeg, MB, Canada.
Predicting long-term outcomes in renal transplant recipients is essential to optimize medical therapy and determine the frequency of post-transplant pathologic and serologic monitoring. Non-adherence and…
2015 American Transplant Congress
Highly Accurate High-Resolution HLA Imputation Using Dense Genotyping Data
B. Keating,¹ Y. Li,¹ T. Guettouche,² K. Olthoff,¹ A. Shaked.¹
¹Surgery (Division of Transplantation), University of Pennsylvania, Philadelphia, PA; ²Genetics, Children's Hospital of Philadelphia, Philadelphia, PA.
HLA similarity between donors (D) and recipients (R) of solid organ transplantation (SOT) plays a central role in determining the risk of rejection or graft-versus-host…
2015 American Transplant Congress
HLA Matching Affects Patient Survival, Graft Survival, and Incidence of Rejection Episodes in Largest Analysis to Date
J. Weiner, Z. Cui, S. Mohan, E. Verna, A. Griesemer, J. Emond.
Columbia Center for Liver Disease and Transplantation, New York Presbyterian-Columbia University Medical Center, New York, NY.
Introduction: Though human leukocyte antigen (HLA) matching between donor and recipient affects both graft and patient survival after kidney and heart transplantation, prior analysis has…
2015 American Transplant Congress
A Single Centre Experience With the Living Donor Kidney Sharing Scheme: More Is Better!
K. Thomas, H. Crawshaw, S. Sinha, P. Mason, P. Harden, C. Winnearls, E. Sharples, S. Reddy, M. Sullivan, J. Gilbert, I. Quiroga, R. Ploeg, A. Vaidya, P. Friend.
Oxford Transplant Centre, Oxford University Hospitals, Oxford, Berkshire, United Kingdom.
Introduction: The living donor kidney sharing scheme was introduced in the UK to expand the donor pool. In this study we have reviewed our experience…
2015 American Transplant Congress
Do Induction Therapy, Patient-Level and Post-Operative Factors Impact Outcomes in Moderate to High Immunologic Risk Simultaneous Kidney-Pancreas Transplantation in the Era of Stringent HLA Cross-Matching?
V. Rohan, D. Taber, D. Taraskiewicz, S. Nadig, J. Mcgillicuddy, K. Chavin, P. Baliga, C. Bratton.
MUSC, Charleston, SC.
Background: Simultaneous kidney and pancreas transplantation (SPK) is a lifesaving procedure for patients with diabetes mellitus. The success of SPK is dependent upon minimization of…