2016 American Transplant Congress
Exome Sequencing and HLA-Independent Prediction of Long-Term Kidney Allograft Function.
Current strategies to improve graft outcome following kidney transplantation consider information at the HLA loci. We asked whether information outside of the HLA loci can…2016 American Transplant Congress
Donor Specific Antibody Used to Predict Crossmatch Results: A Clinically Useful Algorithm Derived from the College of American Pathologists Survey.
Purpose: While there are multiple modalities to perform a preoperative crossmatch for organ transplant surgery, the cytotoxic crossmatch remains the gold standard for detection of…2016 American Transplant Congress
Improving Kidney Allocation System with Higher Resolution.
Northwestern University, Chicago, IL.
Purpose: The new kidney allocation system (KAS) was implemented to help identify compatible donors for the most highly sensitized patients. Our experience, as well as…2016 American Transplant Congress
Presence of Highly Immunogenic Mismatch Eplets Is Associated with Development of Chronic Active Antibody-Mediated Rejection: A First Report from Japan.
Urology, Hokkaido University Hospital, Sapporo, Hokkaido, Japan.
Backgrounds: De novo donor specific antibody (dnDSA) correlates with chronic active antibody-mediated rejection (CAAMR), a major leading cause of graft loss. It will be a…2016 American Transplant Congress
Protective Impact of the Kidney in SPK Transplants – Mechanisms for Improved Outcomes Compared with Solitary Transplants.
Surgery, University of Minnesota, Minneapolis, MN.
Purpose: Outcomes for SPK txps are superior to solitary pancreas txps. The basis for this difference is unknown. We sought to identify the biologic mechanism…2015 American Transplant Congress
Do Induction Therapy, Patient-Level and Post-Operative Factors Impact Outcomes in Moderate to High Immunologic Risk Simultaneous Kidney-Pancreas Transplantation in the Era of Stringent HLA Cross-Matching?
Background: Simultaneous kidney and pancreas transplantation (SPK) is a lifesaving procedure for patients with diabetes mellitus. The success of SPK is dependent upon minimization of…2015 American Transplant Congress
Impact of Pretransplant Pregnancy On Immunization and Immunologic Outcome in Kidney Transplantation
BACKGROUND:The detailed impact of pretransplant pregnancy on HLA alloimmunization and outcome after kidney transplantation is so far not well known.PATIENTS AND METHODS:A retrospective single center…2015 American Transplant Congress
HLA-Cw Mismatches Are Not Associated With Worse Graft Outcomes After Kidney Transplantation Even in High Levels of Antigen Expression
1Cleveland Clinic, Cleveland; 2University of Alexandria, Alexandria, Egypt.
The HLA-Cw antigens are distinct in having relatively lower expression on the cell surface compared to the other HLA class I loci. Higher HLA Cw…2015 American Transplant Congress
Human Leukocyte Antigen Mismatch and Steroid Maintenace in Kidney Transplantation
Nephrology and Hypertension, Allegheny General Hospital, Pittsburgh, PA.
Kidney transplant recipients (KTRs) with zero/minimal HLA mismatches against their donors enjoy superior long term outcomes related to diminished immune response of the recipient against…2015 American Transplant Congress
“Unexpected” Positive Crossmatchs in Zero-HLA-A-B-DR Mismatched or HLA-DR-Matched Organs
Deceased donor kidney allocation is currently prioritized by HLA-A,-B and-DR serologic matching, which disregards both specificity at the allele level, and the contributions of HLA-C,-DQ,…
American Transplant Congress abstracts