Articles tagged "HLA matching"

2022 American Transplant Congress
Successful Transplantation of CPRA 95-100% HLA Incompatible (HLA I) KPD Candidates: A New Combined KPD Matching Strategy at a Single Centre
H. Helwani¹, D. Broering², I. Alahmadi³, T. Ali¹, F. Alzayer⁴, M. Mankowski⁵, A. Algharabli¹
¹Kidney & Pancreas Health Centre, OTCoE, King Faisal Specialist Hospital & Research Centre, Riyadh, Saudi Arabia, ²Organ Transplant Centre of Excellence, King Faisal Specialist Hospital & Research Centre, Riyadh, Saudi Arabia, ³Kidney & Pancreas Transplant Surgery, King Faisal Specialist Hospital & Research Centre, Riyadh, Saudi Arabia, ⁴King Faisal Specialist Hospital & Research Centre, Riyadh, Saudi Arabia, ⁵King Abdullah University for Science & Technology, Saudi Arabia, Saudi Arabia
*Purpose: The six components of the new strategy are Universal flexible assignments of unacceptable antigens (UA); individualized deletion of carefully selected UA; inclusion of compatible…
2022 American Transplant Congress
Does ABO/HLA Matching Matter in Uterus Transplantation?
L. Johannesson¹, M. Askar¹, A. Wall², G. Testa¹
¹Baylor University Medical Center, Dallas, TX, ²Baylor Scott and White Dallas, Dallas, TX
*Purpose: Uterus transplantation (UTx) is the most commonly performed vascular composite allograft and is rapidly becoming an accepted treatment for absolute uterine-factor infertility (AUFI). There…
2022 American Transplant Congress
Clinical Relevance of Class II HLA Mismatches in Living Donor Kidney Transplantation
J. Lan¹, M. Kadatz¹, D. Chang¹, R. Liwski², E. Wagner², P. Campbell², J. Gill¹, J. Gill¹
¹University of British Columbia, Vancouver, BC, Canada, ²On behalf of Canadian HLA Advisory Committee, Ottawa, ON, Canada
*Purpose: The benefit of class II HLA matching is primarily shown in deceased donor kidney transplantation. The objective of this study was to determine the…
2022 American Transplant Congress
HLA-DRB1 and DQB1 Amino Acid Mismatches as Determinants of Kidney Allograft Failure
L. Gragert¹, K. P. McCullough², G. L. Wager³, R. Urbanowicz⁴, R. M. Merion², M. Kamoun⁴
¹Tulane Cancer Center, Tulane University, New Orleans, LA, ²Arbor Research Collaborative for Health, Ann Arbor, MI, ³Tulane University, New Orleans, LA, ⁴University of Pennsylvania, Philadelphia, PA
*Purpose: It was previously reported that HLA-DRB1 amino acid (AA) mismatches (MMs) at peptide-binding pockets of this molecule account for significant incremental risk of kidney…
2022 American Transplant Congress
Understanding The Modification Of Eplet Mismatch Risk By Immunosuppression Regimen
A. Johnson¹, X. Zhang¹, L. Gragert², C. Larsen¹
¹Emory University School of Medicine, Atlanta, GA, ²Tulane University School of Medicine, New Orleans, LA
*Purpose: Solid organ transplant donor-recipient eplet mismatch has been correlated with subsequent donor specific antibody (DSA) formation, antibody mediated rejection, and overall rejection rates. However,…
2022 American Transplant Congress
The Effects of Race-Matching in Small Intestine Transplantation
C. G. Yergin¹, C. Warren², S. Duarte³, T. Beduschi⁴, A. Zarrinpar⁵
¹College of Medicine, University of Florida, Gainesville, FL, ²-, -, AL, ³University of Florida, Gainesville, FL, ⁴Department of Surgery, University of Florida, Gainesville, FL, ⁵University of California Los Angeles, Gainesville, FL
*Purpose: We sought to investigate whether race-matching in small intestine (SI) transplantation correlates with better transplantation outcomes, as well as lower odds of graft rejection.*Methods:…
2022 American Transplant Congress
Improving Value Delivery in Compatible Living Donor Kidney (CLD) Transplant Through Zero-Low Eplet Mismatch via National Kidney Registry (NKR)
S. Anand¹, J. Sanchez-Garcia¹, W. Stapley¹, J. Browning¹, M. Egbert¹, S. Dow¹, A. Raza¹, T. Srinivas², D. Morris¹
¹Intermountain Medical Center, Murray, UT, ²CareDX, South San Francisco, CA
*Purpose: Despite advances in diagnostics and therapeutics, kidney allograft survival rates have not increased considerably. Kidney For Life (KFL) through NKR aims to increase access…
2022 American Transplant Congress
Does Black Race Modify the Risk of Transplant Failure Associated with HLA Mismatch in First Adult Kidney Allografts from Deceased Donors?
K. Atiemo
Tulane University, New Orleans, LA
*Purpose: Current US- based data suggests Black patients awaiting kidney re-transplantation are more likely to be highly sensitized compared to other races. Degree of HLA…
2022 American Transplant Congress
HLA-DQ Mismatches Are More Likely to Be Listed as Unacceptable Antigens After Renal Graft Failure in African American Recipients as Compared to Other Racial/Ethnic Groups
D. Isaacson¹, M. W. Gmeiner², V. Kosmoliaptsis³, J. D. Schold⁴, A. R. Tambur¹
¹Northwestern University, Chicago, IL, ²London School of Economics, London, United Kingdom, ³Cambridge University, Cambridge, United Kingdom, ⁴Cleveland Clinic, Cleveland, OH
*Purpose: Growing evidence suggests that donor-recipient mismatches at the HLA-DQ locus are the most immunogenic and pathogenic, evidenced by generation of DQ donor-specific antibodies (DSA).…
2022 American Transplant Congress
Impact of HLA Matching on Graft Survival in Kidney Transplant Recipients
J. Miller¹, N. Salkowski¹, B. Thompson¹, R. Kandaswamy², P. Stock³, A. Israni¹
¹Scientific Registry of Transplant Recipients, Minneapolis, MN, ²Department of Surgery, University of Minnesota Medical School, Minneapolis, MN, ³Department of Surgery, University of California San Francisco, San Francisco, CA
*Purpose: This study aims to estimate the association of HLA matching at the A, B, DR, and DQ loci with posttransplant graft failure and patient…

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