ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "HLA antigens"

  • 2020 American Transplant Congress

    The Impact of a Positive Crossmatch on KAS Patients and Organs

    J. Lee1, K. Sjöholm2, C. Kjellman2, T. Lorant2, L. Winstedt2, V. Nigro2, K. M. Roupé2, Å. Schiött2, A. Runstrom2, S. Taranto3, T. Baker3, D. Stewart3

    1Medical Affairs, Hansa Biopharma, Camas, WA, 2Hansa Biopharma, Lund, Sweden, 3UNOS, Richmond, VA

    *Purpose: Evaluate the potential effects of offer refusals due to positive crossmatch (+XM) on both patients and re-allocated organs with a focus on waitlist outcomes,…
  • 2020 American Transplant Congress

    Role of APC Subsets in Rejection and Graft-Versus-Host-Disease in Intestinal Transplantation

    H. Dhani, N. Svetlicky, J. Kang, S. Moturi, A. Duttargi, K. Khan, C. Matsumoto, T. S. Fishbein, A. Kroemer

    Transplant Institute, MedStar Georgetown University, Washington, DC

    *Purpose: Intestinal transplantation (ITx) is arguably the most immunogenic and complex organ transplantation, often accompanied with high rates of allograft rejection (AR) and graft-versus-host disease…
  • 2020 American Transplant Congress

    Donor-Recipient Genetic Relationship and Outcomes of Living Donor Liver Transplantation (LDLT): Does it Really Matter?

    A. M. Elsabbagh1, A. Mohamed1, E. M. Elsabbagh2, A. Al-Kurd1, T. Ivanics1, E. Ulrich1, T. Kitajima1, M. Rizzari1, K. Collins1, A. Yoshida1, M. Abouljoud1, S. Nagai1

    1Henry Ford Hospital, Detroit, MI, 2University of Chicago Medical Center, Chicago, IL

    *Purpose: The impact of donor-recipient genetic relationship on LDLT outcomes has been raised by some recent reports. We sought to study this over a large…
  • 2020 American Transplant Congress

    Outcome of Induction Therapies in Low Sensitized Renal Transplant Recipients with Two HLA DR Mismatch in Tacrolimus Era

    K. Soliman1, T. Fulop1, A. Osman2, H. Ali3

    1Medicine, Medical University of South Carolina, Charleston, SC, 2Medicine, Cairo University, Cairo, Egypt, 3Medicine, Royal Stoke, Royal Stoke, United Kingdom

    *Purpose: A mismatch for two HLA DR antigens portends high immunological risk in renal transplant recipients (RTRs). Induction therapies with both rabbit Anti-thymocyte Globulin (r-ATG)…
  • 2020 American Transplant Congress

    Impact of Catch-Up Vaccinations on Anti-HLA Antibody Responses in Pediatric Kidney Transplant Candidates

    H. Sweiss1, J. Lyons2, R. Hall1, K. Hitchman3, D. Ranch4, E. Kincaide1, B. Crowther5

    1University Health System, San Antonio, The University of Texas Health Science Center at San Antonio, San Antonio, TX, 2Loyola University Medical Center, Chicago, IL, 3University Health System, San Antonio, TX, 4The University of Texas Health Science Center at San Antonio, San Antonio, TX, 5University of Colorado Health, Aurora, CO

    *Purpose: Evaluate antibody (Ab) response after catch-up vaccinations in pediatric kidney transplant candidates (PKTC).*Methods: A single center retrospective review of PKTC less than or equal…
  • 2019 American Transplant Congress

    Can Imputation of HLA Allele Level Typing Be Used Clinically in a Multiethnic Population?

    R. M. Engen1, A. M. Jedraszko1, A. Tambur2

    1Ann & Robert H Lurie Children's Hospital of Chicago, Chicago, IL, 2Northwestern University, Chicago, IL

    *Purpose: Assignment of eplets in transplantation for the purpose of matching or risk stratification requires high-resolution HLA typing, which is not readily available. Computer algorithms…
  • 2019 American Transplant Congress

    EBV Latent Proteins Encode for Peptides That Prevent Natural Killer Cell Inhibition

    B. Mbiribindi1, J. K. Pena1, O. Hatton2, C. Romero Moreno1, C. O. Esquivel1, O. M. Martinez1, S. M. Krams1

    1Department of Surgery/ Division of Abdominal Transplant, Stanford University - School of Medicine, Stanford, CA, 2Department of Molecular Biology, Colorado College, Colorado Springs, CO

    *Purpose: Epstein-Barr virus (EBV) infects more than 90% of adults worldwide and is associated with several malignancies, including post-transplant lymphoproliferative disorder (PTLD). Although EBV infection…
  • 2018 American Transplant Congress

    The Relative Immunogenicity of HLA Mismatches in Adult Liver Transplant Recipients

    V. Jucaud,1 A. Shaked,2 M. DesMarais,3 P. Sayre,3 M. Everly.1

    1Terasaki Research Institute, Los Angeles, CA; 2University of Pennsylvania, Philadelphia, PA; 3Immune Tolerance Network, Seattle, WA.

    Determining the immunogenicity of HLA mismatches (MM) may help preventing the appearance of de novo DSA (dnDSA) and avoiding antibody-mediated injuries.We studied the development of…
  • 2018 American Transplant Congress

    The Brazilian Epitope Virtual Crossmatch Protocol: A Reliable Tool for Increasing Kidney Allocation among Highly Sensitized Patients

    L. Sousa,1 A. Silva,1 M. Marroquim,1 A. Coelho,1 A. Lima,1 F. Silva,1 C. Carracosa,2 G. Willcox,3 T. Leão,3 B. Correa,3 E. Guimarães,3 G. Maciel,3 J. Andrade,4 A. Andrade,4 R. Neto,4 S. Cavalcante,4 C. Leão,4 F. Cavalcante,5 A. Holanda,5 N. Gomes,6 A. Rego,6 S. Monte.1

    1UFPI, Teresina, PI, Brazil; 2PUC, Curitiba, PR, Brazil; 3HLA Diagnostico, Recife, PE, Brazil; 4IMIP, Recife, PE, Brazil; 5RHP, Recife, PE, Brazil; 6CNCDO, Recife, PE, Brazil.

    Background: In Brazil (BZ), the kidney allocation policy for highly sensitized patients (HS) (PRA ≥ 80%) does not involve prioritization and transplants 10 times less…
  • 2018 American Transplant Congress

    Informatics Tools for Mapping Molecular HLA Typing Data to UNOS Antigen Equivalencies

    N. Kaur,1 E. Kransdorf,2 M. Pando,3 M. Maiers,4 L. Gragert.1,4

    1Tulane University School of Medicine, New Orleans; 2Cedars-Sinai Heart Institute, Los Angeles; 3Baylor Scott and White, Temple; 4National Marrow Donor Program / Be The Match, Minneapolis.

    Introduction:Molecular HLA typing must be converted to antigen equivalencies for entry into the UNOS database, UNet. Maintaining an up-to-date mapping table for this purpose has…
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