2020 American Transplant Congress
Low HLA Class I Epitope Mismatch Associated with Improved Pancreas Graft Survival in Simultaneous Pancreas-Kidney Transplantation
University of Alabama-Birmingham, Birmingham, AL
*Purpose: Antibody-mediated rejection remains the principal cause of allotransplant graft failure. Human leukocyte antigen (HLA) matching between donor and recipients significantly reduces the risk of…2020 American Transplant Congress
HLA Cw12 in Kidney Transplant Recipients is a Novel Risk Factor for the Development of Post-Transplantation Diabetes: A Single-Centre Retrospective Study
*Purpose: Counselling kidney transplant candidates for their personalised risk of developing post-transplantation diabetes mellitus (PTDM) requires an understanding of risk factors. While some risk factors…2020 American Transplant Congress
The Clinical Significance of C1q+ Antibodies in Pediatric Kidney Transplant Recipients
1Montefiore Medical Center, Bronx, NY, 2Westchester Medical Center, Valhalla, NY
*Purpose: To evaluate the impact of denovo DSA (C1q+ vs C1q-) on graft outcomes in pediatric kidney transplant recipients.*Methods: Children transplanted between 2009 and 2016…2020 American Transplant Congress
Identification of the dnDSA Inducing HLA Mismatches Across Multiple Renal Transplant Centers: A 3-Year Longitudinal Analysis of >11,000 HLA Mismatches in 2271 Patients
*Purpose: The presence of a mismatch (MM) between donor and recipient HLA does not always lead to the patient developing a de novo donor-specific anti-HLA…2020 American Transplant Congress
The Impact of a Positive Crossmatch on KAS Patients and Organs
1Medical Affairs, Hansa Biopharma, Camas, WA, 2Hansa Biopharma, Lund, Sweden, 3UNOS, Richmond, VA
*Purpose: Evaluate the potential effects of offer refusals due to positive crossmatch (+XM) on both patients and re-allocated organs with a focus on waitlist outcomes,…2019 American Transplant Congress
Can Imputation of HLA Allele Level Typing Be Used Clinically in a Multiethnic Population?
*Purpose: Assignment of eplets in transplantation for the purpose of matching or risk stratification requires high-resolution HLA typing, which is not readily available. Computer algorithms…2019 American Transplant Congress
EBV Latent Proteins Encode for Peptides That Prevent Natural Killer Cell Inhibition
*Purpose: Epstein-Barr virus (EBV) infects more than 90% of adults worldwide and is associated with several malignancies, including post-transplant lymphoproliferative disorder (PTLD). Although EBV infection…2018 American Transplant Congress
Eluates from Fine-Needle Allograft Biopsy Increase Donor-Specific Antibody Identification in Antibody Mediated Rejection
1University of Cincinnati, Cincinnati; 2Hoxworth Blood Center, Cincinnati.
Aim. Antibody mediated rejection (AMR) represents a risk for graft loss, and the presence of circulating donor-specific antibody (cDSA) is a major criterion for AMR…2018 American Transplant Congress
Serum Treatment with Fetal Bovine Serum Significantly Increases Luminex-Based HLA Antibody Assay Specificity by Reducing Heterophile Antibody Interference
Mean fluorescence intensity (MFI) values obtained from Luminex-based HLA antibody assays are used to determine the relative strength of HLA antibodies. However, MFI values can…2018 American Transplant Congress
Do Protocol Biopsies in the Highly Sensitized Improve Renal Allograft Survival? A Single Center Evaluation of 2 Year Graft Function
Organ Transplant Center, University of Iowa, Iowa City, IA.
Highly sensitized kidney transplant recipients (hsKTR) are at an increased risk of antibody mediated rejection (AMR). Following implementation of the new kidney allocation system (KAS)…
American Transplant Congress abstracts