ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "HLA antigens"

  • 2022 American Transplant Congress

    HLA-II Subclasses Behave Differently Between Themselves and Between Humans: Cues to Understand Alloreactivity

    S. Beland, O. Desy, M. Marcoux, M. Thivierge, J. Desgagnes, S. A. De Serres

    Transplantation Unit, Renal Division, University Health Center of Quebec, Faculty of Medicine, Universite Laval, Quebec, QC, Canada

    *Purpose: De novo anti-HLA-II DSAs (dnDSA) are associated with antibody-mediated rejection. However, some patients with anti-HLA-II DSAs will not develop rejection, suggesting that the development…
  • 2022 American Transplant Congress

    Site-Directed Mutagenesis as a Tool to Investigate Immunogenicity of HLA Epitopes for Humoral Alloreactivity

    C. H. Maguire1, P. Crivello2, A. Tambur1

    1Northwestern University, Chicago, IL, 2University Hospital Essen, Essen, Germany

    *Purpose: Molecular mismatch load (MML) analysis has been a proposed approach to assess donor/recipient compatibility in support of organ allocation algorithms. While conceptually appealing, MML…
  • 2022 American Transplant Congress

    Acute Graft versus Host Disease (AGVHD) Related to Solid Organ Transplant (SOT) – A Fatal Complication

    H. Shaikh1, J. Awosika1, B. Barakoti1, B. Hambley1, C. Alquist2

    1University of Cincinnati Medical Center, Cincinnati, OH, 2Hoxworth Blood Center, Cincinnati, OH

    *Purpose: This case series highlights our institution's experience with solid-organ transplant (SOT) associated acute graft versus host disease (aGVHD), a rare and deadly complication of…
  • 2022 American Transplant Congress

    Simultaneous Lung and Kidney Transplant in a Young Patient with COVID-19

    M. Bitar1, J. G. Youssef2, S. Yau2, A. Goodarzi2, G. Youssef3

    1Houston Methodist Academic Pulmonary Medicine, Houston Methodist Hospital, Houston, TX, 2Houston Methodist Pulmonary Transplant Center, Houston Methodist Hospital, Houston, TX, 3Department of Lymphoma and Myeloma, MD Anderson Cancer Center, Houston, TX

    *Purpose: Lung transplant is the last resort for COVID-19 refractory ARDS. Dual organ transplant is seen as a relative contraindication at many institutions. We describe…
  • 2022 American Transplant Congress

    Novel Avenue of Allograft Monitoring: Direct Measurement of Donor-Derived Extracellular Vesicles in Human Plasma

    W. W. Woud, D. A. Hesselink, M. J. Hoogduijn, C. C. Baan, K. Boer

    Internal Medicine, Erasmus MC Transplant Institute, Rotterdam, Netherlands

    *Purpose: Extracellular Vesicles (EV) - regarded as “snapshots” of their cell of origin - represent promising liquid biomarkers to monitor allograft function post transplantation. Recently,…
  • 2022 American Transplant Congress

    Racial Differences in HLA Mismatch Potential Among Kidney Registrations

    A. Robinson1, K. Lindblad1, D. Stewart1, J. Kim2, V. Casingal3, P. Lalli3, J. Lunz4, C. Murphey5, M. Pavlakis6

    1UNOS, Richmond, VA, 2Surgery, Keck Medicine of USC, Los Angeles, CA, 3Carolinas Medical Center, Charlotte, NC, 4LifeLink Foundation Transplant Immunology Lab, Tampa, FL, 5Southwest Immunodiagnostics, Inc., San Antonio, TX, 6Beth Israel Deaconess Med Ctr, Boston, MA

    *Purpose: HLA matched kidneys are associated with better long-term post-transplant graft survival. However, prioritizing patients well-matched with an available donor has historically resulted in disparities…
  • 2021 American Transplant Congress

    Antibodies to Hla Molecules Lead to Induction and Release of Circulating Exosomes with Lung Self-Antigens

    R. Ravichandran, M. Smith, R. Bremner, T. Mohanakumar

    St. Joseph’s Hospital and Medical Center, Phoenix, AZ

    *Purpose: Antibodies (Abs) to human leukocyte antigen (HLA) (anti-HLA) can injure allograft by complement-dependent/independent mechanisms. Crosslinking of HLA-class I with Abs associate with integrin β4…
  • 2021 American Transplant Congress

    K562 Cells Expressing HLA-A2 Stimulate Alloreactive CD8+ T Cells

    A. B. Morris, E. Peek, A. Hadley, C. P. Larsen

    Emory Transplant Center, Emory University, Atlanta, GA

    *Purpose: T cell-mediated rejection is a significant factor that leads to graft damage and loss in transplant recipients. Due to the complexity of the TCR:pMHC…
  • 2021 American Transplant Congress

    Disparities in HLA Representation by Single Antigen Reagents in Different Ethnic Populations

    J. C. Quon1, J. Menteer2, N. Fotiadis2, R. M. Lestz2, L. A. Baxter-Lowe2

    1Keck School of Medicine of USC, Los Angeles, CA, 2Children's Hospital Los Angeles, Los Angeles, CA

    *Purpose: It is not possible to test for antibodies against the antigens encoded by every HLA allele due to cost and throughput constraints. When alleles…
  • 2021 American Transplant Congress

    Antibody-mediated Rejection and Sponge Effect in a Redo Lung Transplant Recipient: A Case Report

    A. Arjuna, M. T. Olson, S. Tokman, R. Walia, T. Mohanakumar, A. S. Hashimi, M. A. Smith, R. M. Bremner, A. Omar

    Norton Thoracic Institute, St. Joseph's Hospital and Medical Center, Phoenix, AZ

    *Purpose: Antibody-mediated rejection (AMR) typically presents with elevated titers of circulating donor specific antibodies (DSA) and increased mean fluorescence intensity (MFI), a surrogate marker for…
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