2021 American Transplant Congress
Impact of Rituximab Induction Therapy on Donor-specific Anti-HLA Antibodies in Abo-compatible Kidney Transplant Recipients
*Purpose: Development of de novo donor-specific anti-HLA antibodies (dnDSA) after kidney transplantation remains strongly associated with antibody-mediated rejection (AMR), which leads to poor graft outcome.…2021 American Transplant Congress
Transplant Glomerulopathy in the Absence of Donor-specific HLA Antibodies: Risk Factors, Histopathological Features and Graft Outcome
Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium
*Purpose: Transplant glomerulopathy (TG) is established as a hallmark of chronic antibody-mediated rejection in kidney transplant patients with donor-specific HLA antibodies (HLA-DSA). The clinical importance…2021 American Transplant Congress
The Use of Donor Derived Cell Free DNA in Children to Monitor Therapy of Kidney Rejection
Oregon Health & Science Univ, Portland, OR
*Purpose: Elevated donor-derived cell-free DNA (dd-cfDNA) in the presence of HLA donor-specific antibodies (DSA) are shown to correlate with acute antibody-mediated rejection (AMR) in adult…2021 American Transplant Congress
High Donor-Derived Cell-Free DNA Levels Predict Development of De Novo HLA Donor-Specific Antibodies After Kidney Transplantation – Data from the ADMIRAL Study
*Purpose: Donor-derived cell-free DNA (dd-cfDNA) as a marker of injury can serve to quantify subclinical inflammation and molecular injury. As the release of graft genomic…2021 American Transplant Congress
Bortezomib for Antibody-Mediated Rejection of Renal Transplant in Youth
The Children’s Hospital of Philadelphia, Philadelphia, PA
*Purpose: The purpose of the study was to examine preliminary efficacy and tolerability of bortezomib, a protease inhibitor, in treatment-refractory antibody mediated rejection (AMR) in…2021 American Transplant Congress
Prospective Intensive Monitoring for Anamnestic DSA Responses Allows Near Elimination of Early Clinical AMR
1U Cincinnati, Cincinnati, OH, 2Christ Hospital, Cincinnati, OH
*Purpose: Anamnestic donor specific antibody (aDSA) responses can result in severe, graft threatening antibody-mediated rejection (AMR). We hypothesized that intensive DSA monitoring (IDM) for aDSA…2021 American Transplant Congress
Membrane versus Centrifuge‑Based Therapeutic Plasma Exchange to Treat Antibody-Mediated Rejection in Kidney Transplantation
*Purpose: Therapeutic plasma exchange (TPE) is either performed using a highly permeable filter with standard multifunctional renal replacement equipment (mTPE) or a centrifugation device (cTPE).…2021 American Transplant Congress
Is There a Role for Donor-Specific Antibody Testing in Simultaneous Liver-Kidney Transplantation? A Single Center Analysis of Outcomes
University of Southern California, Los Angeles, CA
*Purpose: Simultaneous liver-kidney transplantation (SLKT) has grown exponentially since its conception in the 1960’s. The role for donor specific antibody (DSA) testing in SLKT is…2021 American Transplant Congress
De Novo Membranous Nephropathy Associated with Antibody-mediated Rejection in Renal Transplant Recipients
*Purpose: Membranous nephropathy (MN) is a rare autoimmune disease, with the potential to develop a persistent nephrotic syndrome and end-stage chronic renal disease in some…2020 American Transplant Congress
HLA-DR/DQ Molecular Mismatch Dictates Early Risk of De Novo Donor-Specific Antibody Development and Offers a Personalized Approach to Immunosuppression Management in Kidney Transplantation
*Purpose: Clinicians have few tools to predict the risk of alloimmune injury in a patient undergoing renal transplantation, as traditional demographic or clinical variables lack…
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