2017 American Transplant Congress
De Novo Donor-Specific Antibody Formation After Kidney Retransplant Is Associated with Specificity Against Class I.
Retransplant (RTx) patients are often sensitized due to donor-specific antibody (DSA) formation, with higher acute rejection rates during subsequent transplants vs patients without DSA. However,…2017 American Transplant Congress
Patient Outcomes Following the Disappearance of Donor Specific Antibody in Crossmatch Positive Simultaneous Liver-Kidney Transplant Recipients.
Background: Simultaneous liver and kidney transplantation (SLKT) remains as the gold standard for patients with chronic renal and liver diseases. Pre-transplant donor-specific antibody (DSA) to…2017 American Transplant Congress
A Novel 3-Dimensional Culture System Enables In Vitro Study of Human Bone Marrow Plasma Cells.
Purpose: Historically, in vitro study of human plasma cells (PCs) has been greatly limited by their short survival (48-72 hrs). Therefore, systems that maintain viability…2017 American Transplant Congress
Donor-Specific B Cell Responses: Predicting the Future of Kidney Transplants.
Allogeneic cell and tissue transplants nearly always evoke B cell responses ascertainable by detecting donor-specific antibodies (DSA) in the circulation of the recipient. DSA are…2017 American Transplant Congress
Prognostic Tools to Choose Candidates for Successful Desensitization.
1Northwestern University, Chicago, IL; 2Johns Hopkins, Baltimore, MD
Antibodies to donor HLA antigens are a barrier to solid organ transplantation. Strategies to desensitize patients have improved, but the ability to predict response to…2017 American Transplant Congress
Renal Transplant Patient Outcomes Following Plasmapheresis, Thymoglobulin, and Rituximab Induction for High Risk DSA Positive Recipients.
Background: Kidney transplantation is associated with improved survival and quality of life relative to dialysis for patients with end-stage renal disease (ESRD). Patients who are…2017 American Transplant Congress
Limited Impact of Pre-Existing Donor Specific HLA Antibodies on Long Term Survival After First Adult Liver Transplantation.
Donor specific antibodies (DSA) are known to play a pivotal role in long term kidney allograft survival. Their importance in liver transplanted patients (LTX) is…2017 American Transplant Congress
De Novo, Non-Donor Specific HLA Antibodies Are Associated with Inferior Allograft Outcomes After Kidney and Simultaneous Kidney-Pancreas Transplantation.
Introduction: Donor specific antibodies [DSAs] occurring after transplantation are associated with poorer outcomes. However the significance of non-donor directed HLA antibodies [ndHLAs] after transplantation in…2017 American Transplant Congress
Specific Gene Expression Signature of Complement-Activating Donor Specific Anti-HLA Antibody-Mediated Rejection in Kidney Allografts.
Complement-binding anti-HLA DSA have demonstrated higher rejection rate and decreased allograft survival. However, their specific effects on rejection pathogenesis have not been identified. We investigated…2017 American Transplant Congress
Presence of Complement Activating Donor Specific Antibodies Is Associated with Poor Renal Allograft Survival: Two Centre Retrospective Study.
Introduction: Complement fixing donor specific antibodies (DSA) as detected by presence of C3d at the time of rejection is associated with poor graft outcome;no studies…
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