Articles tagged "HLA antibodies"

2019 American Transplant Congress
Perioperative Blood Transfusion and Risk for Post-Transplant Sensitization and Rejection
A. Chung¹, M. Kleman¹, T. Pesavento¹, M. Abdel-Rasoul², R. Daloul¹
¹Internal Medicine, Division of Nephrology, The Ohio State University, Columbus, OH, ²Center for Biostatistics and Bioinformatics, The Ohio State University, Columbus, OH
*Purpose: Pre-transplant blood transfusion is a well-established risk factor for sensitization to human leukocyte antigens (HLA). HLA sensitization is associated with increased wait-list time, risk…
2019 American Transplant Congress
Evaluation of the Safety and Tolerability of Clazakizumab® (Anti-IL-6 Monoclonal) as a Desensitization Agent in Highly-HLA Sensitized ESRD Patients (nct03380962)
A. A. Vo, N. Ammerman, E. Huang, A. Peng, R. Najjar, S. Sethi, S. Williamsons, C. Myers, K. Lim, J. Choi, S. C. Jordan
Cedars Sinai Medical Ctr, Los Angeles, CA
*Purpose: Currently, there is growing interest in development of novel immune-modulatory drugs likely to improve allo-antibody reduction in transplantation. Clazakizumab (Vitaeris Inc.) is a humanized…
2019 American Transplant Congress
Presence of DSA Class 2 is Associated with Fibrosis Progression after OLT
M. Sterneck¹, B. Sultani², M. Rodriguez Lago³, E. Grabhorn⁴, A. Briem-Richter⁴, U. Herden⁵, L. Fischer⁵
¹University Medical Center Hamburg Eppendorf, Hamburg, Germany, ²University Transplant Center, University Medical Center Hamburg Eppendorf, Hamburg, Germany, ³Depatment of Medicine, University Medical Center Hamburg Eppendorf, Hamburg, Germany, ⁴Department of Paediatric Medicine, University Medical Center Hamburg Eppendorf, Hamburg, Germany, ⁵Department of Visceral Transplantation, University Medical Center Hamburg Eppendorf, Hamburg, Germany
*Purpose: For decades, donor-specific antibodies (DSA) have been thought not to be clinically relevant in orthotopic liver transplantation (OLT). However, recent studies have shown a…
2019 American Transplant Congress
Global Analysis of Fc-gamma Receptors Binding Capacity of Human Leukocyte Antigen Donor Specific Antibody
E. S. Woodle, A. Girnita
University of Cincinnati Academic Health Center, Cincinnati, OH
*Purpose: Functional assessment of anti-HLA antibodies has historically been limited to complement-binding assays. However, antibodies are capable of inducing injury by complement-independent mechanisms, including Fc-gamma…
2019 American Transplant Congress
Yellow Fever and Renal Transplantation: Influence of Vaccination and Infection on the Emergence of Antibody-Mediated Rejection
M. V. Sousa¹, R. L. Zollner², R. S. Stucchi³, I. F. Boin⁴, E. C. Ataide⁴, M. Mazzali¹
¹Department of Internal Medicine - Division of Nephrology, University of Campinas, Campinas, Brazil, ²Department of Internal Medicine, University of Campinas, Campinas, Brazil, ³Department of Internal Medicine - Division of Infectious Diseases, University of Campinas, Campinas, Brazil, ⁴Surgery Department, University of Campinas, Campinas, Brazil
*Purpose: Yellow fever (YF) is a viral hemorrhagic disease transmitted by mosquitos, with variable clinical disease manifestations from a mild, undifferentiated febrile illness to severe…
2018 American Transplant Congress
Elevated Serum Penteraxin in Cardiac Allograft Antibody Mediated Rejection: From Cytokine Arrays to Patients with ABMR
O. Moussa,³ M. Kavarana,² L. Klingman,¹ J. Felius,¹ S. Hall,¹ M. Askar.¹
¹Baylor Research Institute, Dallas; ²Medical University of South Carolina, Charleston; ³University of Michigan, Ann Arbor, MI.
Pentraxin 3 (PTX3) is soluble protein that has been implicated in in atherosclerosis, endothelial function, hypertension, myocardial infarction and angiogenesis (Fornai et al., 2016). We…
2018 American Transplant Congress
Evaluation of FlowDSA Crossmatch for Detection of Donor-Specific HLA Antibodies
J. Lee, J. Ryu, A. Choi, E-.J. Oh.
Laboratory Medicine, Seoul St. Mary's Hospital, the Catholic University of Korea, Seoul, Republic of Korea.
Background: Donor-specific HLA antibodies (DSA) are detected by different crossmatch techniques. Flow cytometric crossmatching (FCXM) is sensitive method, but it is subject to false (+)…
2018 American Transplant Congress
Interstitial Inflammation is Correlated with DQ Antibodies in Kidney Transplant Recipients
C. Harris, L. Anderson, R. Khaim, J. Choudhuri, R. Shapiro, S. Florman, F. Salem, M. Menon.
Icahn School of Medicine at Mount Sinai, New York.
Background: Studies have shown that borderline rejection (BR) and acute cellular rejection (ACR) often co-occur with antibody-mediated rejection (AMR). We examined the association between interstitial…
2018 American Transplant Congress
Functional Fc Gamma Receptor Gene Polymorphisms and Donor-Specific Antibody-Triggered Transplant Injury
M-.L. Arnold,¹ A. Kainz,² F. Eskandary,² N. Kozakowski,³ M. Wahrmann,² H. Haslacher,⁴ R. Oberbauer,² A. Heilos,⁵ B. Spriewald,⁶ L. Hidalgo,⁷ P. Halloran,⁸ G. Bohmig.²
¹Department of Internal Medicine 3, Friedrich-Alexander University, Erlangen-Nuremberg, Germany; ²Department of Medicine III, Medical University of Vienna, Vienna, Austria; ³Department of Pathology, Medical University of Vienna, Vienna, Austria; ⁴Department of Laboratory Medicine, Medical University of Vienna, Vienna, Austria; ⁵Department of Paediatrics and Adolescent Medicine, Medical University of Vienna, Vienna, Austria; ⁶Department of Internal Medicine 5, Friedrich-Alexander University, Erlangen-Nuremberg, Germany; ⁷Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB, Canada; ⁸Alberta Transplant Applied Genomics Centre, ATAGC, University of Alberta, Edmonton, AB, Canada.
Fc-dependent effector mechanisms may play an important role in antibody-mediated rejection (ABMR). Distinct gene polymorphisms may determine the function of Fc gamma receptors (FcγR), potentially…
2018 American Transplant Congress
Bortezomib in Late Antibody-Mediated Kidney Transplant Rejection – A Double-Blind Randomized Placebo-Controlled Trial (BORTEJECT Study)
F. Eskandary,¹ H. Regele,² G. Bond,¹ N. Kozakowski,² M. Wahrmann,¹ L. Hidalgo,³ H. Haslacher,⁴ C. Kaltenecker,¹ M-.B. Aretin,⁵ R. Oberbauer,¹ J. Reeve,⁶ P. Halloran,⁶ G. Böhmig.¹
¹Nephrology and Dialysis, Medical University Vienna, Viena, Austria; ²Institute of Clinical Pathology, Medical University Vienna, Vienna, Austria; ³Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB, Canada; ⁴Department of Laboratory Medicine, Medical University Vienna, Vienna, Austria; ⁵Pharmacy Department, General Hospital Vienna, AKH, Vienna, Austria; ⁶Alberta Transplant Applied Genomics Centre, University of Alberta, Edmonton, AB, Canada.
Background. Antibody-mediated rejection (ABMR) is a leading cause of long-term kidney transplant loss. Optimal treatment of late ABMR is unclear, and our current knowledge is…