Articles tagged "HLA antibodies"

2019 American Transplant Congress
Pre-emptive Ivig For Dsa Positive Living Donor Kidney Transplant Recipients
B. Abdalla¹, D. Kellner², A. Diaz², Y. Zheng³, E. Reed⁴, Q. J. Zhang⁴
¹Medicine, Division of Nephrology, David Geffen School of Medicine at UCLA, Los Angeles, CA, ²David Geffen School of Medicine at UCLA, Los Angeles, CA, ³UCLA Immunogenetics Center, Los Angeles, CA, ⁴Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA
*Purpose: Intravenous immunoglobulin (IVIG) is used in desensitization regimens to modulate anti-human leukocyte antigen (HLA) donor-specific antibody (DSA) to facilitate transplantation of sensitized patients, however,…
2019 American Transplant Congress
Circulating T Follicular Helper Proliferation And Memory B Cell Activation Correlate With Donor Specific Allo-antibody Occurrence And Antibody-mediated Rejection After Kidney Transplantation
K. Louis¹, C. Macedo¹, M. Marrari¹, B. Ramaswami¹, M. Lucas¹, B. Elinoff¹, M. Yamada¹, X. Gu¹, G. Chalasani¹, A. Zeevi¹, P. Randhawa¹, C. Lefaucheur², D. Metes¹
¹Surgery, University of Pittsburgh, Pittsburgh, PA, ²Inserm Unité mixte de recherche 1160, Paris, France
*Purpose: Crosstalk between T follicular helper (Tfh) cells and B cells is necessary for class-switched antibody generation. The contribution of memory Tfh and B cells…
2019 American Transplant Congress
A National Survey of Immunosuppression Strategies in Intestinal Transplantation
M. Segovia¹, T. Beduschi², J. Boike³, D. Farmer⁴, S. Horslen⁵, K. Iyer⁶, S. Jafri⁷, A. Langnas⁸, C. Matsumoto⁹, A. Mavis¹, G. Mazariegos¹⁰, S. Nagai⁷, J. O'Leary¹¹, Y. Patel¹, D. Sudan¹, N. Sulejmani⁷, B. Summers⁷, T. Schiano⁶
¹Duke, Durham, NC, ²Univ Miami, Miami, FL, ³NWU, Chicago, IL, ⁴UCLA, Los Angeles, CA, ⁵Seattle Child, Seattle, WA, ⁶Mt Sinai, NY, NY, ⁷Henry Ford, Detroit, MI, ⁸UNMC, Omaha, NE, ⁹Georgetown, Washington, DC, ¹⁰UPMC, Pittsburgh, PA, ¹¹Dallas VAMC, Dallas, TX
*Purpose: Review the management of immunosuppression (IS) for intestinal transplantation (IT) in the USA*Methods: A survey was created and sent via email to surgical directors…
2019 American Transplant Congress
Detection and Desensitization of Donor-Specific Antibody Reduces Risk of Early but Not Late Renal Transplant Failure in a Cohort of 1000 Cases
M. Tsai, C. Lee, C. Yang, C. Chen
Department of Surgery, National Taiwan University Hospital, Taipei, Taiwan
*Purpose: The Human Organ Transplant Act in Taiwan was promulgated in 1987 and, thereafter, organ transplantation from brain-dead donors legalized. To review the results of…
2019 American Transplant Congress
Rituximab Desensitization to Liver Transplantaiton Recipients with Preformed Donor Specific Antibodies to Prevent Antibody Mediated Rejecton
Y. Ogura, M. Shizuku, N. Kurata, K. Jobara, H. Kamei
Transplantation Surgery, Nagoya University Hospital, Nagoya City, Japan
*Purpose: Preformed donor-specific antibodies (DSA) are considered as a risk factor after solid organ transplantation. Strong DSA is associated with high mortality and increased risk…
2019 American Transplant Congress
Low Frequency Of Canonical Human Leukocyte Antigen Alloimmunization In Heart Transplantation Candidates With Ventricular Assist Devices
G. K. Mahowald¹, S. L. Saidman¹, G. Lewis², V. Pattanayak¹
¹Pathology, Massachusetts General Hospital, Boston, MA, ²Cardiology, Massachusetts General Hospital, Boston, MA
*Purpose: Screening for anti-HLA antibodies in heart transplantation candidates is complicated by transfusions as well as by the presence of ventricular assist devices (VADs), which…
2019 American Transplant Congress
Early CXCR5⁺PD1⁺ICOS⁺Circulating Follicular T Helpers Are Associated with De Novo Donor-Specific Anti-HLA Antibodies after Renal Transplantation
R. Danger¹, M. Chesneau¹, F. Delbos², S. Lebot¹, C. Kerleau¹, A. Chenouard¹, A. Cesbron², M. Giral³, S. Brouard³
¹CRTI- INSERM UMR 1064- ITUN- Labex IGO -Université de Nantes -CHU Nantes, Nantes, France, ²Laboratoire Histocompatibilité et Immunogénétique - Etablissement Français du sang, Nantes, France, ³Centre d’Investigation Clinique en Biothérapie, Centre de ressources biologiques, Fondation Centaure, CRTI- INSERM UMR 1064- ITUN- Labex IGO -Université de Nantes -CHU Nantes, Nantes, France
*Purpose: Donor specific anti-HLA antibodies (DSA) are a major risk factor associated with renal allograft outcome. As a trigger of B cell antibody production, T…
2019 American Transplant Congress
Outcomes in Preformed Donor-Specific Human Leukocyte Antibody Positive Living Kidney Transplant Recipients Desensitized with Intravenous Immunoglobulin and Rituximab
Y. kakuta¹, M. Okumi¹, T. Kanzawa¹, K. Unagami², H. Ishida², K. Tanabe¹
¹Urology, Tokyo Women's Medical University, Tokyo, Japan, ²Organ Transplant Medicine, Tokyo Women's Medical University, Tokyo, Japan
*Purpose: Donor-specific antibody (DSA) is associated with antibody-mediated rejection (ABMR) and is a significant immunologic barrier to graft and patient survival. Pre-transplant desensitization therapy has…
2019 American Transplant Congress
High Prevalence of De Novo Donor-Specific Antibodies during Rejection after Liver Transplantation
J. Colmenero, N. Flores, A. Diaz, M. Vasquez, P. Ruiz, G. Crespo, J. Martorell, M. Navasa
Liver Transplant Unit, Hospital Clinic Barcelona, Barcelona, Spain
*Purpose: Anti-HLA donor specific antibodies (dnDSA) after liver transplantation (LT) are currently under investigation. Recent studies show an incidence of dnDSA after LT ranging from…
2019 American Transplant Congress
De Novo Donor Specific Antibody and Panel Reactivity Antibody Are Critical Risk Factors for Antibody Mediated Rejection of Kidney Allograft after Simultaneous Liver-Kidney Transplantation (a Single Center Study Using Surveillance Renal Biopsies)
Y. Sun¹, A. Zhang², Z. Zaky²
¹Avalon Medical University, Willemstad, Netherlands Antilles, ²Cleveland Clinic, Cleveland, OH
*Purpose: Even though the liver may provide immunologic protection to the kidney from hyperacute rejection, previous publications suggest this protective effect is not sufficient to…