Articles tagged "HLA antibodies"

2020 American Transplant Congress
Donor-Specific B Cell Frequency Assessed by a Novel Multiplex Bead-Based Assay Predicts Graft Failure in Kidney Transplant Recipients
Z. Ilyas, A. Akl, D. Pinelli, L. Gallon, A. R. Tambur, M. Ansari
Northwestern University Feinberg School of Medicine, Chicago, IL
*Purpose: Kidney transplant recipients with sensitization to HLA defined by a high percentage of Panel Reactive Antibodies (PRA) or Donor-specific anti-HLA antibodies (DSA) are at…
2020 American Transplant Congress
Desensitization Combining Costimulation Blockade with Proteasome Inhibition in Highly Sensitized Transplant Candidates
S. Restaino¹, D. Jennings², G. Serban³, E. Vasilescu³, G. Sayer¹, N. Uriel¹, K. Takeda⁴, Y. Naka⁴, M. Farr¹, M. V. Habal¹
¹Cardiology, Columbia University Irving Medical Center, New York, NY, ²School of Nursing, Columbia University Irving Medical Center, New York, NY, ³Pathology&Cell Biology, Columbia University Irving Medical Center, New York, NY, ⁴Cardiothoracic Surgery, Columbia University Irving Medical Center, New York, NY
*Purpose: Antibodies to human leukocyte antigens (HLA) pose a significant barrier to transplantation. Strategies to reduce allosensitization have modest efficacy and may result in antibody…
2020 American Transplant Congress
A Single-Center Analysis of Using Allele-Level 11 HLA Loci Information on cPRA and Organ-Allocation Points in Kidney Transplant Candidates
C. Maguire¹, P. Muluhngwi¹, E. Kransdorf², L. Gragert³, A. R. Tambur¹
¹Northwestern University, Chicago, IL, ²Cedars-Sinai Heart Institute, Beverly Hills, CA, ³Tulane University, New Orleans, LA
*Purpose: Calculated panel reactive antibodies (cPRA) is used by the United Network for Organ Sharing (UNOS) to quantify degree of HLA sensitization and assign priority…
2020 American Transplant Congress
The Impact of DSA Screening in Stable Kidney Transplant Recipients in the 1st Year Post-Transplant
A. Sharma¹, D. Jorgensen², R. Mehta¹, P. Sood¹, C. Wu¹, C. M. Puttarajappa¹, A. Tevar¹, S. Hariharan¹
¹Thomas E. Starzl Transplant Institute, Renal Electrolyte Division, University of Pittsburgh Medical Center, Pittsburgh, PA, ²Thomas E. Starzl Transplant Institute, University of Pittsburgh Medical Center, Pittsburgh, PA
*Purpose: The importance of Donor Specific Antibody (DSA) as a screening tool within the 1st year post kidney transplant in stable patients remains unclear. We…
2020 American Transplant Congress
The Role of Galectin-1 and Basement Membrane Remodeling in Kidney Antibody-Mediated Rejection
S. Clotet-Freixas¹, C. McEvoy¹, I. Batruch², M. Kotlyar³, C. Pastrello³, J. Van¹, M. Arambewela¹, A. Boshart¹, S. Farkona¹, A. Bozovic⁴, V. Kulasingam⁴, P. Chen¹, I. Jurisica³, A. Chruscinski¹, R. John⁴, A. Konvalinka⁵
¹Toronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada, ²Department of Laboratory Medicine and Pathobiology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada, ³Krembil Research Institute, University Health Network, Toronto, ON, Canada, ⁴Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada, ⁵Department of Medicine, Division of Nephrology, University Health Network, Toronto, ON, Canada
*Purpose: Antibody-mediated rejection (AMR), the leading cause of kidney graft loss, is caused by anti-HLA and non-HLA antibodies against proteins in two main kidney compartments:…
2020 American Transplant Congress
The Ratio between Naïve and Memory B Cells is Associated with Development of Early Donor-Specific Antibodies within the First Month after Lung Transplantation
A. Hitz¹, R. Bellmàs Sanz¹, F. Ius², J. Kühne¹, B. Wiegmann², W. Sommer², J. Salman², T. Siemeni², C. Kühn², M. Avsar², A. Haverich², I. Tudorache², G. Warnecke², C. Falk¹
¹Institute of Transplant Immunology, Hannover Medical School MHH, Hannover, Germany, ²Department of Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School MHH, Hannover, Germany
*Purpose: After lung transplantation (LuTx), the development of early donor HLA-specific antibodies (eDSA) has been shown to be associated with antibody-mediated rejection (AMR) and poor…
2020 American Transplant Congress
CD56^DimCD16^Bright NK Cells from Kidney Transplant Recipients with Antibody-Mediated Rejection Display Increased Proliferation, Self-Renewal, Pro-Inflammatory and Cytotoxic Profile
E. A. Bailly¹, K. Louis¹, C. Macedo¹, B. Ramaswami¹, M. Lucas¹, A. Zeevi¹, C. Lefaucheur², D. Metes¹
¹Department of Surgery, Thomas E. Starzl Transplantation Institute, Pittsburgh, PA, ²INSERM UMR-S976. Endothelium, Inflammation & Alloreactivity, Université de Paris, France
*Purpose: Contribution of NK cells to antibody-mediated rejection (ABMR) injuries have recently been highlighted through transcriptomic analysis and immunohistochemistry of kidney and heart allograft biopsies.…
2020 American Transplant Congress
Single Dose Rituximab and Anti-Thymocyte Globulin (ATG) Induction in Hypersensitized Kidney Transplant Recipients
A. X. Wang, U. Wang, S. Busque, C. R. Lenihan
Stanford University School of Medicine, Stanford, CA
*Purpose: Hypersensitized kidney transplant recipients (calculated panel reactive antibody (cPRA) ≥98%) may represent a population at high risk of posttransplant immunologic events. While access to…
2020 American Transplant Congress
Follow Up of Imlifidase (IdeS) Desensitized Kidney Transplant Recipients
S. C. Jordan¹, R. A. Montgomery², T. Lundgren³, C. Legendre⁴, N. Desai⁵, G. Eckerwall⁶, L. Laxmyr⁶, H. Olsson⁶, A. Runström⁶, Å. Schiött⁶, K. Sjöholm⁶, E. Sonesson⁶, L. Winstedt⁶, T. Lorant⁷, C. Kjellman⁶
¹Cedars Sinai Medical Center, Los Angeles, CA, ²NYU Langone Health Transplant Institute, New York, NY, ³Karolinska University Hospital, Stockholm, Sweden, ⁴Hospital Necker & Paris Descartes University, Paris, France, ⁵Johns Hopkins University, Baltimore, MD, ⁶Hansa Biopharma AB, Lund, Sweden, ⁷Uppsala University, Uppsala, Sweden
*Purpose: 46 highly sensitized patients received kidney transplants after desensitization with imlifidase (currently under investigation) across four Phase 2 clinical trials, and 6-month safety and…
2020 American Transplant Congress
Development and Impact of DSA after Lung Transplant
M. Henderson¹, G. Morris², C. Burt¹, A. Feist¹, J. Kozuch¹, E. Schonhoft³, G. Yung³, T. Floreth³, K. Afshar³, E. Golts⁴, M. Mariski¹
¹Pharmacy, University of California San Diego Health, San Diego, CA, ²Immunology, University of California San Diego Health, San Diego, CA, ³Pulmonology, University of California San Diego Health, San Diego, CA, ⁴Cardiothoracic Surgery, University of California San Diego Health, San Diego, CA
*Purpose: Antibody-mediated rejection (AMR) after lung transplant (LT) is a serious complication, potentially leading to graft failure despite advances in drug therapy. Diagnosis and treatment…