Articles tagged "HLA antibodies"

2020 American Transplant Congress
Influence of Human Leukocyte Antigen Status and Gender of Positive Crossmatch Patients on Long-Term Survival Outcomes of Antibody Incompatible Renal Transplantation
N. R. Macha¹, A. Abimbola¹, N. Khovanova², D. Briggs³, N. Krishnan⁴
¹CIRAL, Coventry University, Coventry, United Kingdom, ²School of Engineering, University of Warwick, Warwickshire, United Kingdom, ³Director, Tissue Typing Lab, NHSBT, Birmingham, United Kingdom, ⁴Consultant Transplant Nephrologist and Visiting Professor, CIRAL, University Hospital Coventry & Warwickshire, Coventry, United Kingdom
*Purpose: Human Leukocyte Antigen (HLA) sensitization is a significant obstacle which limits the use of renal transplantation, but it serves as a therapeutic option for…
2020 American Transplant Congress
Significance of DSA Clearance in Antibody Mediated Rejection in Pediatric Kidney Transplant Recipients on 1 Year Outcomes: Interim Results from PARAMOUr “Pediatric Renal AMr Outcomes” Study
I. Ashoor¹, R. Garro², S. Solomon³, A. Jain⁴, M. Kallash⁵, K. Twombley⁶
¹LSHUSC Children's Hospital New Orleans, New Orleans, LA, ²Emory University School of Medicine, Atlanta, GA, ³New York Medical College, Valhalla, NY, ⁴Wayne State University School of Medicine, Detroit, MI, ⁵Nation Wide Children's Hospital, Columbus, OH, ⁶Medical University of South Carolina, Charleston, SC
*Purpose: Little is known about how donor specific antibody (DSA) clearance correlates with outcomes in pediatric antibody mediated rejection (AMR). There is also little data…
2020 American Transplant Congress
Quantitative Analysis of Humoral Immunity by Flow-Cytometric Crossmatch Using Molecules of Equivalent Soluble Fluorochromosome (FCXM-MESF)
H. Ishida, M. Furusawa, T. Shimizu, M. Okumi, Y. Kakuta, K. Omoto, K. Tanabe
Tokyo Womens, Tokyo, Japan
*Purpose: In this study, we examined the quantitative significance of humoral immunity by flow-cytometric crossmatch using molecules of equivalent soluble fluorochromosome (FCXM-MESF) in recipients of…
2020 American Transplant Congress
HLA-DR/DQ Molecular Mismatch Dictates Early Risk of De Novo Donor-Specific Antibody Development and Offers a Personalized Approach to Immunosuppression Management in Kidney Transplantation
S. Davis¹, C. Wiebe², K. Campbell¹, C. Anobile³, M. Aubrey³, A. Wiseman¹, E. Pomfret¹, P. Nickerson², J. Cooper¹
¹University of Colorado, Aurora, CO, ²University of Manitoba, Winnipeg, MB, Canada, ³Clinimmune, Aurora, CO
*Purpose: Clinicians have few tools to predict the risk of alloimmune injury in a patient undergoing renal transplantation, as traditional demographic or clinical variables lack…
2020 American Transplant Congress
HLA Diversity Affects Epitope Mismatch Cutoffs Utilized to Predict De Novo DSA Development and Graft Rejection in Renal Transplant Patients
A. Ram¹, S. Dhingra², H. Quach¹, P. T. Jindra¹
¹Immune Evaluation Laboratory-Surgery, Baylor College of Medicine, Houston, TX, ²Pathology, Baylor College of Medicine, Houston, TX
*Purpose: Recent studies have investigated epitope matching in order to determine its predictive power in determining renal transplant outcomes, both in terms of de novo…
2020 American Transplant Congress
Failure to Launch; a Multi-Centre Study of Potential Live Donors in Southeast Nigeria
C. G. Okwuonu¹, G. O. Achor², Q. L. Ogana³, C. Kingsley⁴
¹Internal Medicine, Federal Medical Centre, Umuahia, Nigeria, ²Department of Surgery, Federal Medical Centre, Umuahia, Nigeria, ³Internal Medicine, Beatitudes Mediplex and Kidney Care Centre, Umuahia, Nigeria, ⁴Internal Medicine, Beatitudes Mediplex and Kidney Care Centre, Aba, Nigeria
*Purpose: To determine the socio-demographic characteristics of potential living kidney donors, donor motivation, incidental findings on clinical evaluation and some identified factors that precluded eventual…
2020 American Transplant Congress
HLA-Antibody Develops Preferentially in Healthy Subjects with a T-bet^hiB Cell Response to Vaccine
A. Nellore, G. R. Martens, J. T. Killian, J. Houp, E. Zumaquero, B. Mousseau, J. Bradley, F. Zhou, P. A. Goepfert, F. E. Lund
University of Alabama, Birmingham, AL
*Purpose: Bystander B cell differentiation into antibody (Ab) secreting cells (ASCs) may augment alloimmunity in the HLA-sensitized patient. Recently, a population of FcrL5+IgDnegB cells that…
2020 American Transplant Congress
The Impact of a Positive Crossmatch on KAS Patients and Organs
J. Lee¹, K. Sjöholm², C. Kjellman², T. Lorant², L. Winstedt², V. Nigro², K. M. Roupé², Å. Schiött², A. Runstrom², S. Taranto³, T. Baker³, D. Stewart³
¹Medical Affairs, Hansa Biopharma, Camas, WA, ²Hansa Biopharma, Lund, Sweden, ³UNOS, Richmond, VA
*Purpose: Evaluate the potential effects of offer refusals due to positive crossmatch (+XM) on both patients and re-allocated organs with a focus on waitlist outcomes,…
2020 American Transplant Congress
Assessment of Rapid Optimized Flow Cytometric Crossmatch (FCXM) Assay with Luminex Class I Single Antibody Test
J. Yoo¹, S. Lee², J. Jang³, A. Choi², E. Oh¹
¹Department of Laboratory Medicine, Catholic University of Korea, Seoul, Korea, Republic of, ²Department of Laboratory Medicine, Seoul St. Mary's Hospital, Seoul, Korea, Republic of, ³Department of Biomedical Science, Graduate School, Catholic University of Korea, Seoul, Korea, Republic of
*Purpose: Flow cytometric crossmatch test (FCXM) is critical to detect donor-specific antibodies (DSA) in transplant patients. Rapid, simple and sensitive FCXM procedure can improve HLA…
2020 American Transplant Congress
Can HLA-DQ Molecular Mismatch Analysis Be Used to Predict Generation of De Novo Donor-Specific Antibody at an Individual Patient Level?
D. Pinelli¹, M. Casillas Abundis¹, R. Hod Dvorai², H. McDowell¹, A. R. Tambur¹
¹Northwestern University, Chicago, IL, ²SUNY Upstate Medical University, Syracuse, NY
*Purpose: De novo donor-specific antibodies (dnDSA), especially to HLA-DQ, are one of the leading causes of late kidney graft failure. Many investigators have attempted to…