ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "HLA antibodies"

  • 2020 American Transplant Congress

    Assessment of Rapid Optimized Flow Cytometric Crossmatch (FCXM) Assay with Luminex Class I Single Antibody Test

    J. Yoo1, S. Lee2, J. Jang3, A. Choi2, E. Oh1

    1Department of Laboratory Medicine, Catholic University of Korea, Seoul, Korea, Republic of, 2Department of Laboratory Medicine, Seoul St. Mary's Hospital, Seoul, Korea, Republic of, 3Department of Biomedical Science, Graduate School, Catholic University of Korea, Seoul, Korea, Republic of

    *Purpose: Flow cytometric crossmatch test (FCXM) is critical to detect donor-specific antibodies (DSA) in transplant patients. Rapid, simple and sensitive FCXM procedure can improve HLA…
  • 2020 American Transplant Congress

    Can HLA-DQ Molecular Mismatch Analysis Be Used to Predict Generation of De Novo Donor-Specific Antibody at an Individual Patient Level?

    D. Pinelli1, M. Casillas Abundis1, R. Hod Dvorai2, H. McDowell1, A. R. Tambur1

    1Northwestern University, Chicago, IL, 2SUNY Upstate Medical University, Syracuse, NY

    *Purpose: De novo donor-specific antibodies (dnDSA), especially to HLA-DQ, are one of the leading causes of late kidney graft failure. Many investigators have attempted to…
  • 2020 American Transplant Congress

    The Association between Alloimmunity and De Novo Glomerulonephritis Post Kidney Transplantation

    P. Khairallah, J. Kamal, E. Vasilescu, I. Batal, G. Dube

    Columbia University Medical Center, New York, NY

    *Purpose: In contrast to recurrent immune complex-mediated glomerulonephritis (ICGN), de novo ICGN of the allograft is poorly characterized. We hypothesize that alloimmunity results in immune-complex…
  • 2020 American Transplant Congress

    Clinical Significance of T Cell and B Cell Epitope Prediction as a Risk Factor of De Novo DSA Production after Kidney Transplantation

    T. Kobayashi1, K. Iwasaki1, T. Tomosugi2, Y. Miwa1, M. Niemann3, E. Spierings4, K. Horimi1, Y. Matsuoka1, A. Takeda2, N. Goto2, S. Narumi2, Y. Watarai2

    1Aichi Medical University School of Medicine, Nagakute, Japan, 2Nagoya Daini Red Cross Hospital, Nagoya, Japan, 3PIRCHE AG, Berlin, Germany, 4UMC Utrecht, Utrecht, Netherlands

    *Purpose: Chronic antibody-mediated rejection caused by de novo DSA (dnDSA) is a major cause of graft failure. Risk prediction of dnDSA would be important for…
  • 2020 American Transplant Congress

    A Multicenter Analysis of the Proportion and Pattern of Unexplained HLA Antibodies in Kidney Recipients without a History of Sensitization

    J. Lan1, J. S. Gill1, H. M. Gebel2, R. A. Bray2, R. Liwski3, A. Vinson4, A. Greenshields3, S. Dobrer5, O. Gunther5, K. Sherwood5, F. H. Claas6, S. Heidt6, G. Karahan6, J. Gill7, M. Gill1, U. Varyani1, P. Jindal1, P. Keown5

    1Medicine, Division of Nephrology, University of British Columbia, Vancouver, BC, Canada, 2Pathology, Emory University, Atlanta, GA, 3Pathology, Dalhousie University, Halifax, NS, Canada, 4Nephrology, Dalhousie University, Halifax, NS, Canada, 5Pathology, University of British Columbia, Vancouver, BC, Canada, 6Immunohaematology and Blood Transfusion, Leiden University Medical Center, Leiden, Netherlands, 7Nephrology, Emory University, Atlanta, GA

    *Purpose: Previous studies report a high prevalence of unexplained antibody reactivities on the single antigen bead (SAB) test. In a contemporary multicenter cohort of non-sensitized…
  • 2020 American Transplant Congress

    Donor-Specific Antibody Test as a Screening Tool for Stable Long-Term Kidney Transplant Recipients

    M. Mohamed1, L. Hidalgo2, S. Parajuli1, N. Garg1, F. Aziz1, K. Swanson1, E. Jochaim1, D. Mandelbrot1, A. Djamali1, B. Astor1

    1Department of Nephrology, Madison, WI, 2Department of Surgery, Madison, WI

    *Purpose: Donor-specific antibody (DSA) is an established biomarker predicting antibody mediated rejection (AMR), but at substantial cost. The utility of DSA test as a screening…
  • 2020 American Transplant Congress

    Crosstalk between TLR4 and HLA Class I Mediates P-Selectin Expression and Monocyte Capture to Endothelial Cells

    Y. Jin, N. M. Valenzuela, R. A. Sosa, E. F. Reed

    Pathology and Laboratory Medicine, University of California Los Angeles, Los Angeles, CA

    *Purpose: Transplant recipients developing donor specific HLA antibodies (DSA) are at risk for acute and chronic antibody-mediated rejection (AMR). DSA contribute to the process of…
  • 2020 American Transplant Congress

    Effects of Donor Specific Antibodies in Intestinal/Multivisceral Transplant Recipients

    K. Klein1, M. Keck2, E. Langewisch2, S. Merani2, M. Leick2

    1University Health System, San Antonio, TX, 2Nebraska Medicine, Omaha, NE

    *Purpose: Evaluate the effects of donor specific antibodies (DSAs) on outcomes in post-intestinal/multivisceral (MV) transplant patients and describe the presentation of DSAs post-transplant.*Methods: This single-center…
  • 2020 American Transplant Congress

    Is the Epitope Mismatch Load Enough to Identify HLA-DQ Mismatches with a Low Risk for De Novo DSA Development?

    V. Jucaud1, M. Stegall2, C. Schinstock2, R. Heilman3, L. Rebellato4, M. Samaniego-Picota5, D. Leeser4, M. Gandhi2, J. Beaumont1, M. Everly1

    1Terasaki Research Institute, Los Angeles, CA, 2Mayo Clinic, Rochester, MN, 3Mayo Clinic, Phoenix, AZ, 4East Carolina University, Greenville, NC, 5Henry Ford Transplant Institute, Detroit, MI

    *Purpose: The development of de novo donor-specific anti-HLA antibodies (dnDSA) remains a major risk factor for poor long-term kidney allograft outcomes. In particular, anti-HLA-DQ dnDSAs,…
  • 2020 American Transplant Congress

    Association between Longer Hospitalization and Development of De Novo Donor Specific Antibody in Simultaneous Liver­-Kidney Transplant Recipients

    M. Yazawa1, O. Cseprekal2, R. A. Helmick1, M. Talwar1, V. Balaraman1, P. S. Podila3, S. Fossey4, S. K. Satapathy5, J. D. Eason1, M. Z. Molnar1

    1James D. Eason Transplant Institute, Methodist University Hospital, Memphis, TN, 2Department of Transplantation and Surgery, Semmelweis University, Budapest, Hungary, 3Faith & Health Division, Methodist Le Bonheur Healthcare, Memphis, TN, 4Transplant Immunology Laboratory, DCI Inc., Nashville, TN, 5Sandra Atlas Bass Center for Liver Diseases & Transplantation, Northshore University Hospital/Northwell Health, Manhasset, NY

    *Purpose: De novo Donor Specific Antibodies (DSA) are considered a risk factor for worsening kidney allograft outcomes in recipients after simultaneous liver-​kidney transplantation (SLK). No…
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