2018 American Transplant Congress
Scoring Transplant Glomerulopathy Using Morphometry: Correlation with Banff Criteria
William J.von Liebig Transplant Center, Mayo Clinic, Rochester, MN.
Background: Transplant glomerulopathy (TG) is a prognostic marker for graft survival. Still, scoring TG using the Banff cg-score remains a challenge and no assessments in…2018 American Transplant Congress
Pre-Existing Allograft Diabetic Nephropathy from Diabetic Donor is Reversible after Kidney Transplantation in Non-Diabetic Recipient
1Hokkaido University Hospital, Sapporo, Japan; 2Sapporo City General Hospital, Sapporo, Japan.
【Introduction】The shortage of kidney donor has limited the treatment of patients with end-stage kidney disease. To use diabetic donor with normal renal function is would…2017 American Transplant Congress
The Impact of Early Clinical and Subclinical T Cell Rejection After Kidney Transplantation.
Medicine and Surgery, University of Pittsburgh, Pittsburgh, PA
Purpose: To evaluate the impact of early Clinical(C-TCMR) and Sub-Clinical(SC-TCMR) T Cell Mediated Rejection on short-term allograft histology and function.Methods: We examined adult kidney alone…2017 American Transplant Congress
Subclinical Histologic Findings Are Observed in 25% of Stable Adult Liver Transplant Recipients (ALTRs) Screened for Immunosuppression Withdrawal (ISW): OPTIMAL (NCT02533180).
OPTIMAL is a 6-center ISW study in non-autoimmune, non-HCV ALTRs ≥3 yrs post-transplant (tx). Studies have shown a correlation between portal inflammation associated with tissue…2017 American Transplant Congress
Compartmental Infiltration of Kidney Allograft with Monocyte-Macrophage Subtypes Defines the Type of Rejection.
Purpose: Rejection significantly worsens the graft function and survival. We studied monocyte-macrophage compartmental infiltration of 62 kidney transplant biopsies with diagnosis of: acute antibody mediated…2017 American Transplant Congress
Circulating Donor-Specific Anti-HLA Antibodies Accelerate the Progression of Interstitial Fibrosis in Kidney Allografts.
Paris Translational Research Center for Organ Transplantation, Paris, France
Interstitial fibrosis represents a major cause of kidney allograft failure. Addressing the causes of accelerated ageing of kidney allografts represents an important challenge to improve…2017 American Transplant Congress
Glomerular CD45 Immunostaining in Post Perfusion Graft Biopsies Predicting Rejection.
Renal Transplant Unit, University Hospitals Coventry, Coventry, United Kingdom
Introduction: Recipients of incompatible renal allografts remain at risk of developing AMR after transplantation. Current microarray analysis of allograft biopsies showed similar disturbances in AMR…2017 American Transplant Congress
Determinants of Severe Interstitial Fibrosis in Kidney Allografts: Major Impact of Circulating Donor-Specific Anti-HLA Antibodies.
Paris Translational Research Center for Organ Transplantation, Paris, France
Interstitial fibrosis represents a major cause of kidney allograft failure. We investigated the independent contribution of circulating donor-specific anti-HLA antibodies (DSA) in the development of…2017 American Transplant Congress
Early Antibody-Mediated Rejection C4d Status Remains a Marker of Prognosis in HLA-Incompatible Kidney Transplantation.
1CHP, Porto, Portugal; 2IPST, Porto, Portugal
Banff criteria for the diagnosis of antibody-mediated rejection (AMR) in kidney transplantation (KT) was recently updated to include the entity of C4d negative AMR, if…2017 American Transplant Congress
DSA Presence Does Not Affect Renal Histology and Clinical Outcome in Chronic Active Antibody Mediated Rejection.
1Erasmus MC, Rotterdam, Netherlands; 2Leiden UMC, Leiden, Netherlands
Introduction. Chronic active antibody mediated rejection (caABMR) is a major cause of long term renal allograft dysfunction. It is defined by the presence of microvascular…
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