ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Highly-sensitized"

  • 2020 American Transplant Congress

    Clazakizumab (Anti-IL-6 Monoclonal) as an Agent to Reduce Donor Specific Hla Antibodies (DSA) and Improve Outcomes in Patients with Chronic & Active Antibody-Mediated Rejection Post-Kidney Transplantation (NCT03380377)

    S. C. Jordan, N. Ammerman, M. Toyoda, S. Ge, E. Huang, A. Peng, S. Sethi, R. Najjar, E. Ortiz, M. Chu, A. De Guzman, I. Kim, K. Lim, J. Choi, A. Vo

    Cedars Sinai Medical Ctr, Los Angeles, CA

    *Purpose: Highly sensitized (HS) patients are at an increased risk for chronic antibody mediated rejection (cABMR) and graft loss due to persistent, deleterious DSA production.…
  • 2020 American Transplant Congress

    Assessment of Infectious Complications Following ABO-Blood Group Incompatible Renal Transplant

    J. Banbury1, T. Loosier1, C. Lin2, K. Gutierrez1

    1University of Alabama at Birmingham Hospital, Birmingham, AL, 2Center for Clinical and Translational Science, University of Alabama at Birmingham, Birmingham, AL

    *Purpose: In response to the ongoing organ shortage, ABO-incompatible (ABOi) renal transplant (RT) provides an alternative option for patients with end-stage kidney disease. Literature suggests…
  • 2020 American Transplant Congress

    High PRA Increases Rejection but Does Not Worsen Renal Function in the First Year Post Kidney Transplant with Alemtuzumab Induction

    B. Wise, A. Freeman, M. Janusek, S. Anders, L. Hutchinson, U. Kaszubski, D. Marroquin, D. Martin, H. Bohorquez

    Ochsner Medical Center, New Orleans, LA

    *Purpose: Sensitization is an important immunologic risk factor considered in renal allograft allocation and influences immunosuppression. Unfortunately, there is a lack of consensus regarding the…
  • 2020 American Transplant Congress

    Anti-T Lymphocyte Immunoglobulins versus Basiliximab in Highly Sensitized Kidney-Transplant Patients without Preformed DSAs: The Satir Study

    N. Kamar1, L. Couzi2, L. Albano3, A. Durrbach4, V. Pernin5, L. Esposito1, M. Lequintrec5, P. Merville2, A. Del Bello1

    1Toulouse University Hospital, Toulouse, France, 2Bordeaux University Hospital, Bordeaux, France, 3Nice University Hospital, Nice, France, 4Henri Mondor University Hospital, Paris, France, 5Montpellier University Hospital, Montpellier, France

    *Purpose: Two prospective studies that were performed before the era of highly sensitive solid-phase assays have shown a lower incidence of acute rejection in highly…
  • 2020 American Transplant Congress

    Development of a New Kidney Paired Donation (KPD) Program: Starting a Domino Chain with a Deceased Donor

    L. Furian1, C. Di Bella2, C. Silvestre2, F. Neri2, F. Tuci2, M. Cardillo3, E. Cozzi4, P. Rigotti1

    1Kidney and Pancreas Transplantation Unit, University of Padova, Padua, Italy, 2Kidney and Pancreas Transplantation Unit, University of Padova, Italy, Italy, 3Italian National Transplant Center, Rome, Rome, Italy, 4Transplant Immunology Unit, Padova University-Hospital, Padua, Padua, Italy

    *Purpose: The option of initiating a domino chain of living donor kidney transplants with a deceased donor (DD) has been proposed but never enforced. The…
  • 2020 American Transplant Congress

    Waiting List and Transplant Outcomes of Highly Sensitized Kidney Patients

    R. Schmitz, O. K. Jawitz, S. J. Knechtle, A. M. Jackson

    Department of Surgery, Duke University Medical Center, Durham, NC

    *Purpose: Sensitized kidney transplant candidates represent a growing population on the waiting list. Transplantation of patients with high calculated panel reactive antibody (CPRA) can be…
  • 2019 American Transplant Congress

    Compatible Pairs in Paired Kidney Exchange – Are There Winners and Loosers?

    V. Chipman1, B. Lee1, M. Cooper2, M. C. Cuffy3, M. Ronin4, G. Hil4, S. Flechner5, A. Thomas6, D. A. Mandelbrot7, A. D. Waterman8, C. E. Freise1, G. R. Roll1

    1UCSF, San Francisco, CA, 2Georgetown Univ, Washington, DC, 3UC Hospital, Cincinnati, OH, 4NKR, Babylon, NY, 5Cleavland Clinic, Cleavland, OH, 6Johns Hopkins, Baltimore, MD, 7Univ of Wisconsin, Madison, WI, 8UCLA and Terasaki Research Institute, Los Angeles, CA

    *Purpose: To understand patterns of participation for compatible pairs and their impact in increasing paired donation in a national registry.*Methods: Favorable pairs (FP) are defined…
  • 2019 American Transplant Congress

    Three-Year Outcomes of Highly-Sensitized Kidney Transplant Recipients Desensitized with Imlifidase (IdeS)

    E. Huang1, J. Choi1, A. Vo1, A. Peng1, R. Najjar1, S. Sethi1, C. Kjellman2, L. Winstedt2, N. Ammerman1, S. C. Jordan1

    1Cedars Sinai Medical Center, Los Angeles, CA, 2Hansa Medical, Lund, Sweden

    *Purpose: The HLA-incompatible (HLAi) barrier has been traversed using desensitization therapies with IVIg, rituximab and/or plasmapheresis, although antibody-mediated rejection (ABMR) continues to be observed in…
  • 2019 American Transplant Congress

    B Cell Derived Exosomes Are Associated with Antibody Mediated Rejection in Kidney Transplant Recipients Desensitized for a Positive Cross-Match

    D. Cucchiari1, V. Tubita2, M. J. Ramirez-Bajo2, J. Rovira2, F. E. Borràs3, L. Carreras-Planella3, A. Hertig4, F. Oppenheimer1, F. Diekmann1, I. Revuelta1

    1Renal Transplant Unit, Hospital Clínic, Barcelona, Spain, 2Laboratori Experimental de Nefrologia i Trasplantament, IDIBAPS, Barcelona, Spain, 3REMAR-IVECAT group, IGTP, Badalona, Spain, 4Department of Nephrology and Kidney Transplantation, Hôpital Tenon, Paris, France

    *Purpose: Kidney transplant recipients undergoing desensitization for a positive cross-match are at very high risk of developing Antibody-Mediated Rejection (AMR). Because of desensitization, peripheral circulating…
  • 2019 American Transplant Congress

    Characterization of HLA Antibodies by C3d Assay and IgG Subclasses in Sensitized Kidney Transplant Patients

    A. Casillas-Abundis, J. M. Arreola-Guerra, J. Alberu, M. I. Solis-G, L. Llorente, J. Granados, M. Vilatoba, R. Cruz-Martinez, L. Morales-Buenrostro, A. G. Contreras

    Instituto Nacional de Ciencias Medicas y Nutricion SZ, Mexico City, Mexico

    *Purpose: To determine the detection rate of IgG subclasses (IgGsc) and C3d-binding HLA-antibodies (abs) in a cohort of highly sensitized kidney transplant patients.*Methods: We evaluated,…
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