Articles tagged "Highly-sensitized"

2020 American Transplant Congress
Infectious Complications in Elderly Kidney Transplant Recipients Undergoing Desensitization
S. Sethi, R. Najjar, A. Peng, A. Vo, S. Jordan, E. Huang
Cedars Sinai Medical Center, West Hollywood, CA
*Purpose: Data is limited on the impact of desensitization on infectious complications in elderly kidney transplant (KT) recipients. We examined infectious complications in elderly KT…
2020 American Transplant Congress
Preformed Anti-HLA Donor-Specific Antibodies Immunological Risk Assessment: The Importance of HLA Antibody Locus-Specificity
V. Jucaud¹, A. Babu², D. Briggs³, N. Krishnan⁴, D. Mitchell⁵, M. Everly¹
¹Terasaki Research Institute, Los Angeles, CA, ²University Hospitals Coventry and Warwickshire, Coventry, United Kingdom, ³NHS Blood and Transplant, Birmingham, United Kingdom, ⁴University Hospitals Coventry and Warwickshire NHS Trust, Coventry, United Kingdom, ⁵University of Warwick Medical School, Coventry, United Kingdom
*Purpose: The screening of preformed donor-specific HLA antibodies (pfDSA) by single antigen bead assays has increased the complexity of pre-transplant patient risk stratification. We evaluated…
2020 American Transplant Congress
Feasibility and Limitations of Desensitization Therapy in Highly Sensitized Pediatric ESRD Patients: A Single-Center Experience
J. Steggerda¹, H. Pizzo², X. Zhang³, J. Garrison², I. Kim¹, M. Haas⁴, A. Vo¹, S. Jordan¹, D. Puliyanda²
¹Comprehensive Transplant Center, Cedars-Sinai Med Ctr, West Hollywood, CA, ²Pediatric Nephrology, Cedars-Sinai Med Ctr, West Hollywood, CA, ³HLA Laboratory, Cedars-Sinai Med Ctr, West Hollywood, CA, ⁴Renal Pathology, Cedars-Sinai Med Ctr, West Hollywood, CA
*Purpose: There are a growing number of pediatric (peds) patients (pts) awaiting renal transplantation (tx) who are considered highly sensitized (HS). We report long-term outcomes…
2020 American Transplant Congress
Impact of Desensitization Strategies with Proteosome Inhibition and Costimulation Blockade on Xenoreactive Humoral Responses
B. P. Lovasik¹, A. J. Matar¹, D. A. Faber¹, D. V. Mathews¹, C. P. Breeden¹, S. C. Kim¹, A. J. Tector², A. B. Adams¹
¹Emory University School of Medicine, Atlanta, GA, ²University of Miami, Miami, FL
*Purpose: “Delayed” antibody-mediated xenograft rejection is the one of the most important obstacles to clinical application of pig organ xenografts. The aim of this study…
2020 American Transplant Congress
Risk Stratification in Antibody Incompatible Kidney Transplantation: Can Aggressive Rejection be Avoided?
S. Punjala¹, M. Ibrahim¹, N. Vallant¹, N. Kessaris¹, O. Shaw², N. Mamode¹
¹Department of Nephrology, Renal Transplant and Urology, Guy's and St. Thomas' NHS Foundation Trust, London, United Kingdom, ²Clinical Transplantation Laboratory, Guy's and St. Thomas' NHS Foundation Trust, London, United Kingdom
*Purpose: Our experience in antibody incompatible kidney transplantation, and anecdotal reports, suggest that a specific form of rejection, which we term Early Aggressive Antibody Mediated…
2020 American Transplant Congress
Clazakizumab (Anti-IL-6 Monoclonal) as an Agent to Reduce Donor Specific Hla Antibodies (DSA) and Improve Outcomes in Patients with Chronic & Active Antibody-Mediated Rejection Post-Kidney Transplantation (NCT03380377)
S. C. Jordan, N. Ammerman, M. Toyoda, S. Ge, E. Huang, A. Peng, S. Sethi, R. Najjar, E. Ortiz, M. Chu, A. De Guzman, I. Kim, K. Lim, J. Choi, A. Vo
Cedars Sinai Medical Ctr, Los Angeles, CA
*Purpose: Highly sensitized (HS) patients are at an increased risk for chronic antibody mediated rejection (cABMR) and graft loss due to persistent, deleterious DSA production.…
2019 American Transplant Congress
Prevention of Ischemia Reperfusion Injury (IRI) & ABMR in HLA Sensitized Patients Treated with C1 Esterase Inhibitor (C1INH): Long-Term Follow Up
A. A. Vo, E. Huang, N. Ammerman, J. Choi, I. Kim, A. Peng, R. Najjar, S. Sethi, K. Lim, S. C. Jordan
Cedars Sinai Medical Ctr, Los Angeles, CA
*Purpose: Delayed graft function (DGF) after kidney transplantation is a consequence of IRI/DGF. IRI/DGF requires intense medical management, is costly and predisposes to risk for…
2019 American Transplant Congress
Outcomes after Incompatible Living Donor Kidney Transplantation in Older Recipients
J. Long¹, K. Jackson¹, J. Motter¹, S. Bae¹, A. Massie¹, M. Waldram¹, K. Covarrubias¹, J. Chen¹, B. Orandi², N. Desai¹, D. Segev¹, J. Garonzik-Wang¹
¹Johns Hopkins School of Medicine, Baltimore, MD, ²Surgery, University of Alabama at Birmingham, Birmingham, AL
*Purpose: Older individuals are the fastest-growing sub-group of transplant candidates who may face increased risks when considering incompatible living donor kidney transplantation (IKT) due to…
2019 American Transplant Congress
Differences in Wait Time, Graft Quality and Outcome for Pediatric Kidney Recipients in the Post-Kidney Allocation System Era
P. Singer, K. Eng, L. Castellanos Reyes, C. Sethna, L. Teperman, E. Grodstein
Northwell Health, Manhasset, NY
*Purpose: Though a purpose of the kidney allocation system (KAS) enacted in 2014 was to prioritize the transplantation of highly sensitized recipients, we explored the…
2019 American Transplant Congress
BK Virus Infection among Kidney Transplant Recipients with High Immunological Risk and Strong Immunosupression
G. Ledesma, M. O. Lopez, G. Carreño, M. J. Santana, M. A. Vaca, E. Gonzalez, C. Jimenez
Nephrology, Hospital Universitario La Paz, Madrid, Spain
*Purpose: BK virus infection represents one of the main viral infections within the first year after kidney transplantation, closely linked to the degree of immunosupresion.…

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