2020 American Transplant Congress
A Single Centre Report of Renal Transplantation Against a Positive Crossmatch Due to HLA-DP Donor Specific Antibodies without Prior Antibody Removal
*Purpose: In renal transplantation, the clinical effects of donor specific antibodies (DSA) against HLA-DP are unclear. We report successful kidney transplants in three highly sensitised…2020 American Transplant Congress
Accommodating Increasing Volumes without Knocking Down Walls: Update on an Infusion Center’s Growth
Comprehensive Transplant Center, Cedars Sinai Medical Center, Los Angeles, CA
*Purpose: An increase in transplants performed at the medical center in comparison to the limited availability of outpatient infusion chairs and home infusion companies compelled…2020 American Transplant Congress
Risk Factors for Antibody-Mediated Rejection after Adult Liver Transplantation with Preformed Donor-Specific Antibodies: A Single Center Experience
Div. of HBP Surgery and Transplantation, Dept. of Surgery, Kyoto University, Kyoto, Japan
*Purpose: In general, preformed donor-specific antibodies (pDSAs) can lead to an increased risk of antibody-mediated rejection (AMR); however, their prevalence, risk factors, and the efficacy…2020 American Transplant Congress
Desensitization Combining Costimulation Blockade with Proteasome Inhibition in Highly Sensitized Transplant Candidates
*Purpose: Antibodies to human leukocyte antigens (HLA) pose a significant barrier to transplantation. Strategies to reduce allosensitization have modest efficacy and may result in antibody…2020 American Transplant Congress
Kidneys from Pediatric Donors Are Preferentially Allocated to Adult Highly Sensitized and Not to Pediatrics Under the New Kidney Allocation System (KAS)
*Purpose: In 12/2014, the new Kidney Allocation System (KAS) assigned allocation priority to highly sensitized (HS) recipients while maintaining access to donors for pediatric patients…2020 American Transplant Congress
Blocking Complement Component C3 in a Sensitized Nonhuman Primate Model of Kidney Allotransplantation
*Purpose: Sensitized transplant recipients represent a challenge due to the presence of donor-specific antibodies (DSA), which increase the risk of antibody-mediated rejection. Complement inhibition has…2019 American Transplant Congress
Validation of Gene Expression Signatures Associated with Antibody-Mediated Rejection (ABMR) in Renal Allograft Biopsies (Bx) of HLA-Sensitized Patients
*Purpose: "Thoroughly validated gene transcripts” in renal Bx was adopted as one of the criteria for ABMR diagnosis in the latest Banff classification. Previously, we…2019 American Transplant Congress
Vaccination And Allosensitization In Solid Organ Transplant Candidates
*Purpose: Clinical practice guidelines recommend vaccinating patients awaiting solid organ transplantation (SOT) against vaccine-preventable infections, but there is little evidence to suggest that vaccination reduces…2019 American Transplant Congress
Rejection, Infectious, and Renal Outcomes with Perioperative Desensitization in Orthotopic Heart Transplant Recipients
University of Maryland Medical Center, Baltimore, MD
*Purpose: Pre-transplant allosensitization remains a significant barrier to organ allocation and a paucity of evidence exists to demonstrate the efficacy and safety of perioperative desensitization…2019 American Transplant Congress
5-Year Post-Transplant Outcomes with Bortezomib-Based Desensitization in Renal Transplant Recipients
1U of Cincinnati, Cincinnati, OH, 2Christ Hospital, Cincinnati, OH
*Purpose: Renal transplant (RT) after desensitization (DS) has been associated with increased rejection rates. Proteasome inhibitor(PI)-based DS yields significant reductions in HLA Ab among sensitized…
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