2020 American Transplant Congress
Outcomes of HLAi Transplant in CPRA 98-100 after Desensitization: Single Center Experience
1Cedars Sinai Medical Ctr, Los Angeles, CA, 2Pathology, Cedars Sinai Medical Ctr, Los Angeles, CA
*Purpose: The new KAS implementation aimed at increasing equity in organ allocation for broadly sensitized (HS) patients. However, recent data shows that for the most…2020 American Transplant Congress
Third and Fourth Kidney Re-Transplants: A 20-Year Single Centre Experience
*Purpose: Re-transplantation may be associated with management dilemmas including repeat allocation of limited kidney allografts to same individuals in the face of an increasing waiting…2020 American Transplant Congress
Anti-HLA IgM Antibodies are Unaffected by Imlifidase (IdeS) Treatment
*Purpose: The immunoglobulin G (IgG)-degrading cysteine protease, imlifidase (IdeS) is an IgG endopeptidase under development as a rapid desensitization treatment in kidney transplantation. Imlifidase is…2020 American Transplant Congress
Outcomes of Post-Transplant Desensitization in High Immunological Risk Deceased Donor Kidney Transplant Recipients
Virginia Commonwealth University, Richmond, VA
*Purpose: The kidney allocation system (KAS) was changed in 2015 to increase access to transplants for highly sensitized patients. However, recent data suggests that even…2020 American Transplant Congress
Evaluation of the Safety and Tolerability of Clazakizumab® as a Desensitization Agent in Highly-HLA Sensitized ESRD Patients (NCT03380962): 12m Follow-Up
*Purpose: IL-6 mediates inflammation and activation of T-cells, B-cells & plasma cells. Thus, IL-6 may represent an important target for desensitization (DES). Here we report…2020 American Transplant Congress
Infectious Complications in Elderly Kidney Transplant Recipients Undergoing Desensitization
Cedars Sinai Medical Center, West Hollywood, CA
*Purpose: Data is limited on the impact of desensitization on infectious complications in elderly kidney transplant (KT) recipients. We examined infectious complications in elderly KT…2020 American Transplant Congress
Preformed Anti-HLA Donor-Specific Antibodies Immunological Risk Assessment: The Importance of HLA Antibody Locus-Specificity
*Purpose: The screening of preformed donor-specific HLA antibodies (pfDSA) by single antigen bead assays has increased the complexity of pre-transplant patient risk stratification. We evaluated…2020 American Transplant Congress
Feasibility and Limitations of Desensitization Therapy in Highly Sensitized Pediatric ESRD Patients: A Single-Center Experience
*Purpose: There are a growing number of pediatric (peds) patients (pts) awaiting renal transplantation (tx) who are considered highly sensitized (HS). We report long-term outcomes…2020 American Transplant Congress
Impact of Desensitization Strategies with Proteosome Inhibition and Costimulation Blockade on Xenoreactive Humoral Responses
1Emory University School of Medicine, Atlanta, GA, 2University of Miami, Miami, FL
*Purpose: “Delayed” antibody-mediated xenograft rejection is the one of the most important obstacles to clinical application of pig organ xenografts. The aim of this study…2020 American Transplant Congress
Risk Stratification in Antibody Incompatible Kidney Transplantation: Can Aggressive Rejection be Avoided?
*Purpose: Our experience in antibody incompatible kidney transplantation, and anecdotal reports, suggest that a specific form of rejection, which we term Early Aggressive Antibody Mediated…
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