ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Highly-sensitized"

  • 2020 American Transplant Congress

    Impact of Desensitization Strategies with Proteosome Inhibition and Costimulation Blockade on Xenoreactive Humoral Responses

    B. P. Lovasik1, A. J. Matar1, D. A. Faber1, D. V. Mathews1, C. P. Breeden1, S. C. Kim1, A. J. Tector2, A. B. Adams1

    1Emory University School of Medicine, Atlanta, GA, 2University of Miami, Miami, FL

    *Purpose: “Delayed” antibody-mediated xenograft rejection is the one of the most important obstacles to clinical application of pig organ xenografts. The aim of this study…
  • 2020 American Transplant Congress

    Risk Stratification in Antibody Incompatible Kidney Transplantation: Can Aggressive Rejection be Avoided?

    S. Punjala1, M. Ibrahim1, N. Vallant1, N. Kessaris1, O. Shaw2, N. Mamode1

    1Department of Nephrology, Renal Transplant and Urology, Guy's and St. Thomas' NHS Foundation Trust, London, United Kingdom, 2Clinical Transplantation Laboratory, Guy's and St. Thomas' NHS Foundation Trust, London, United Kingdom

    *Purpose: Our experience in antibody incompatible kidney transplantation, and anecdotal reports, suggest that a specific form of rejection, which we term Early Aggressive Antibody Mediated…
  • 2020 American Transplant Congress

    Clazakizumab (Anti-IL-6 Monoclonal) as an Agent to Reduce Donor Specific Hla Antibodies (DSA) and Improve Outcomes in Patients with Chronic & Active Antibody-Mediated Rejection Post-Kidney Transplantation (NCT03380377)

    S. C. Jordan, N. Ammerman, M. Toyoda, S. Ge, E. Huang, A. Peng, S. Sethi, R. Najjar, E. Ortiz, M. Chu, A. De Guzman, I. Kim, K. Lim, J. Choi, A. Vo

    Cedars Sinai Medical Ctr, Los Angeles, CA

    *Purpose: Highly sensitized (HS) patients are at an increased risk for chronic antibody mediated rejection (cABMR) and graft loss due to persistent, deleterious DSA production.…
  • 2020 American Transplant Congress

    Assessment of Infectious Complications Following ABO-Blood Group Incompatible Renal Transplant

    J. Banbury1, T. Loosier1, C. Lin2, K. Gutierrez1

    1University of Alabama at Birmingham Hospital, Birmingham, AL, 2Center for Clinical and Translational Science, University of Alabama at Birmingham, Birmingham, AL

    *Purpose: In response to the ongoing organ shortage, ABO-incompatible (ABOi) renal transplant (RT) provides an alternative option for patients with end-stage kidney disease. Literature suggests…
  • 2020 American Transplant Congress

    High PRA Increases Rejection but Does Not Worsen Renal Function in the First Year Post Kidney Transplant with Alemtuzumab Induction

    B. Wise, A. Freeman, M. Janusek, S. Anders, L. Hutchinson, U. Kaszubski, D. Marroquin, D. Martin, H. Bohorquez

    Ochsner Medical Center, New Orleans, LA

    *Purpose: Sensitization is an important immunologic risk factor considered in renal allograft allocation and influences immunosuppression. Unfortunately, there is a lack of consensus regarding the…
  • 2020 American Transplant Congress

    Anti-T Lymphocyte Immunoglobulins versus Basiliximab in Highly Sensitized Kidney-Transplant Patients without Preformed DSAs: The Satir Study

    N. Kamar1, L. Couzi2, L. Albano3, A. Durrbach4, V. Pernin5, L. Esposito1, M. Lequintrec5, P. Merville2, A. Del Bello1

    1Toulouse University Hospital, Toulouse, France, 2Bordeaux University Hospital, Bordeaux, France, 3Nice University Hospital, Nice, France, 4Henri Mondor University Hospital, Paris, France, 5Montpellier University Hospital, Montpellier, France

    *Purpose: Two prospective studies that were performed before the era of highly sensitive solid-phase assays have shown a lower incidence of acute rejection in highly…
  • 2020 American Transplant Congress

    Development of a New Kidney Paired Donation (KPD) Program: Starting a Domino Chain with a Deceased Donor

    L. Furian1, C. Di Bella2, C. Silvestre2, F. Neri2, F. Tuci2, M. Cardillo3, E. Cozzi4, P. Rigotti1

    1Kidney and Pancreas Transplantation Unit, University of Padova, Padua, Italy, 2Kidney and Pancreas Transplantation Unit, University of Padova, Italy, Italy, 3Italian National Transplant Center, Rome, Rome, Italy, 4Transplant Immunology Unit, Padova University-Hospital, Padua, Padua, Italy

    *Purpose: The option of initiating a domino chain of living donor kidney transplants with a deceased donor (DD) has been proposed but never enforced. The…
  • 2020 American Transplant Congress

    Waiting List and Transplant Outcomes of Highly Sensitized Kidney Patients

    R. Schmitz, O. K. Jawitz, S. J. Knechtle, A. M. Jackson

    Department of Surgery, Duke University Medical Center, Durham, NC

    *Purpose: Sensitized kidney transplant candidates represent a growing population on the waiting list. Transplantation of patients with high calculated panel reactive antibody (CPRA) can be…
  • 2020 American Transplant Congress

    In-Vivo Application of Ides (Imlifidase) in Nonhuman Primates Results in Xenoreactive Desensitization: A Novel Anti-Humoral Therapy

    B. P. Lovasik1, A. J. Matar1, D. A. Faber1, D. V. Mathews1, C. Breeden1, S. C. Kim1, A. J. Tector2, A. Robertson3, C. Kjellman3, A. B. Adams1

    1Emory University School of Medicine, Atlanta, GA, 2University of Miami, Miami, FL, 3HANSA Biopharma, Lund, Sweden

    *Purpose: Antibody-mediated rejection is a formidable barrier to xenograft survival. A novel anti-humoral IdeS therapy, which cleaves serum IgG, represents a promising therapy to reduce…
  • 2020 American Transplant Congress

    The Clinical Relevance of cPRA in 0-ABDRDQ Mismatched Kidney Transplants

    J. H. Lan1, D. Chang1, M. Kadatz1, J. Gill1, H. M. Gebel2, J. S. Gill1

    1Medicine, Division of Nephrology, University of British Columbia, Vancouver, BC, Canada, 2Pathology, Emory University, Atlanta, GA

    *Purpose: The clinical relevance of immune sensitization as measured by cPRA in kidney transplantation remains uncertain.*Methods: We identified 4,057 adult, first, kidney only transplant recipients…
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