Articles tagged "Highly-sensitized"

2021 American Transplant Congress
Sensitized Lung Candidates Experience Reduced Access to Donor Organs
K. Lindblad¹, R. Goff², D. Stewart²
¹UNOS, Richmond, VA, ²UNOS, Richmnd, VA
*Purpose: Most studies of sensitization in transplant candidates have focused on kidney candidates, and unacceptable antigens (UAs) for non-kidney candidates are believed to be underreported.…
2021 American Transplant Congress
HLA Haplotype Frequency and Racial Disparities in Access to Transplant Among Highly Sensitized Kidney Transplant Candidates
L. Gragert¹, M. Kadatz², D. Chang², H. Gebel³, D. Stewart⁴, E. Kransdorf⁵, S. Brar², S. Vaishnav², J. Gill², J. Lan²
¹Tulane University, New Orleans, LA, ²University of British Columbia, Vancouver, BC, Canada, ³Emory University, Atlanta, GA, ⁴UNOS, Richmond, VA, ⁵Cedars-Sinai, Beverly Hills, CA, Canada
*Purpose: Despite implementation of the Kidney Allocation System (KAS) which prioritizes sensitized patients, sensitized Black individuals are less likely to receive a transplant than non-Black…
2020 American Transplant Congress
Assessment of Infectious Complications Following ABO-Blood Group Incompatible Renal Transplant
J. Banbury¹, T. Loosier¹, C. Lin², K. Gutierrez¹
¹University of Alabama at Birmingham Hospital, Birmingham, AL, ²Center for Clinical and Translational Science, University of Alabama at Birmingham, Birmingham, AL
*Purpose: In response to the ongoing organ shortage, ABO-incompatible (ABOi) renal transplant (RT) provides an alternative option for patients with end-stage kidney disease. Literature suggests…
2020 American Transplant Congress
High PRA Increases Rejection but Does Not Worsen Renal Function in the First Year Post Kidney Transplant with Alemtuzumab Induction
B. Wise, A. Freeman, M. Janusek, S. Anders, L. Hutchinson, U. Kaszubski, D. Marroquin, D. Martin, H. Bohorquez
Ochsner Medical Center, New Orleans, LA
*Purpose: Sensitization is an important immunologic risk factor considered in renal allograft allocation and influences immunosuppression. Unfortunately, there is a lack of consensus regarding the…
2020 American Transplant Congress
Anti-T Lymphocyte Immunoglobulins versus Basiliximab in Highly Sensitized Kidney-Transplant Patients without Preformed DSAs: The Satir Study
N. Kamar¹, L. Couzi², L. Albano³, A. Durrbach⁴, V. Pernin⁵, L. Esposito¹, M. Lequintrec⁵, P. Merville², A. Del Bello¹
¹Toulouse University Hospital, Toulouse, France, ²Bordeaux University Hospital, Bordeaux, France, ³Nice University Hospital, Nice, France, ⁴Henri Mondor University Hospital, Paris, France, ⁵Montpellier University Hospital, Montpellier, France
*Purpose: Two prospective studies that were performed before the era of highly sensitive solid-phase assays have shown a lower incidence of acute rejection in highly…
2020 American Transplant Congress
Development of a New Kidney Paired Donation (KPD) Program: Starting a Domino Chain with a Deceased Donor
L. Furian¹, C. Di Bella², C. Silvestre², F. Neri², F. Tuci², M. Cardillo³, E. Cozzi⁴, P. Rigotti¹
¹Kidney and Pancreas Transplantation Unit, University of Padova, Padua, Italy, ²Kidney and Pancreas Transplantation Unit, University of Padova, Italy, Italy, ³Italian National Transplant Center, Rome, Rome, Italy, ⁴Transplant Immunology Unit, Padova University-Hospital, Padua, Padua, Italy
*Purpose: The option of initiating a domino chain of living donor kidney transplants with a deceased donor (DD) has been proposed but never enforced. The…
2020 American Transplant Congress
Waiting List and Transplant Outcomes of Highly Sensitized Kidney Patients
R. Schmitz, O. K. Jawitz, S. J. Knechtle, A. M. Jackson
Department of Surgery, Duke University Medical Center, Durham, NC
*Purpose: Sensitized kidney transplant candidates represent a growing population on the waiting list. Transplantation of patients with high calculated panel reactive antibody (CPRA) can be…
2020 American Transplant Congress
In-Vivo Application of Ides (Imlifidase) in Nonhuman Primates Results in Xenoreactive Desensitization: A Novel Anti-Humoral Therapy
B. P. Lovasik¹, A. J. Matar¹, D. A. Faber¹, D. V. Mathews¹, C. Breeden¹, S. C. Kim¹, A. J. Tector², A. Robertson³, C. Kjellman³, A. B. Adams¹
¹Emory University School of Medicine, Atlanta, GA, ²University of Miami, Miami, FL, ³HANSA Biopharma, Lund, Sweden
*Purpose: Antibody-mediated rejection is a formidable barrier to xenograft survival. A novel anti-humoral IdeS therapy, which cleaves serum IgG, represents a promising therapy to reduce…
2020 American Transplant Congress
The Clinical Relevance of cPRA in 0-ABDRDQ Mismatched Kidney Transplants
J. H. Lan¹, D. Chang¹, M. Kadatz¹, J. Gill¹, H. M. Gebel², J. S. Gill¹
¹Medicine, Division of Nephrology, University of British Columbia, Vancouver, BC, Canada, ²Pathology, Emory University, Atlanta, GA
*Purpose: The clinical relevance of immune sensitization as measured by cPRA in kidney transplantation remains uncertain.*Methods: We identified 4,057 adult, first, kidney only transplant recipients…
2020 American Transplant Congress
A Single Centre Report of Renal Transplantation Against a Positive Crossmatch Due to HLA-DP Donor Specific Antibodies without Prior Antibody Removal
Y. Marie¹, T. Key², A. Halawa¹
¹Renal Transplantation, Sheffield Kidney Institute, Sheffield, United Kingdom, ²2.Department of Histocompatibility and Immunogenetics, Sheffield, United Kingdom
*Purpose: In renal transplantation, the clinical effects of donor specific antibodies (DSA) against HLA-DP are unclear. We report successful kidney transplants in three highly sensitised…