Articles tagged "Hepatocytes"

2015 American Transplant Congress
Hepatocyte-Related miR-193a-3p Is Over-Expressed in Allograft Biopsy from Liver Tolerant Recipients
R. Danger, J. Lozano, E. Bonaccorsi-Riani, E. Kodela, R. Mas-Malavila, M.-C. Londono, M. Martinez, A. Rimola, M. Martinez-Llordella, A. Sanchez-Fueyo.
Department of Liver Sciences, Faculty of Life Sciences & Medicine, MRC Transplant Centre, King's College London, London, United Kingdom; Liver Unit and Bioinformatic Platform, IDIBAPS, University of Barcelona and Hospital Clinic Barcelona, Barcelona, Spain.
While liver transplantation is the treatment of choice for end-stage liver diseases, its success is compromised by the need to administer life-long immunosuppression, which negatively…
2015 American Transplant Congress
Distinctive Roles of mTORC1 Vs. mTORC2 in Liver Ischemia-Reperfusion Injury
H. Zhou,^1,2 J. Zhu,^1,3 S. Yue,¹ M. Zhang,³ R. Busuttil,¹ Q. Xia,³ J. Kupiec-Weglinski,¹ Y. Zhai.¹
¹The Dumont-UCLA Transplant Center, UCLA, Los Angeles; ²Liver Transplant Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China; ³Liver Surgery, Renji Hospital, Shanghai Jiaotong University, Shanghai, China.
Mammalian target of rapamycin (mTOR) exists in two complexes to regulate diverse biological processes. Although mTOR complex 1, the canonical target of rapamycin, has been…
2015 American Transplant Congress
Donor CD47 Plays a Critical Role in the Control of Alloreactive T Cell Activation Following Hepatocyte Transplantation
M. Zhang,^1,2 H. Wang,¹ N. Navarro-Alvarez,¹ Y. Zheng,² Y.-G. Yang.¹
¹Columbia Center for Translational Immunology, Columbia University Medical Center, New York, NY; ²First Hospital, Jilin University, Changchun, Jilin, China.
Background: The interspecies incompatibility of CD47 is an important mechanism triggering rejection of cellular xenografts, including both hematopoietic and non-hematopoietic cells, by recipient macrophages. Our…