Articles tagged "Hepatocytes"

2015 American Transplant Congress
Donor CD47 Plays a Critical Role in the Control of Alloreactive T Cell Activation Following Hepatocyte Transplantation
M. Zhang,^1,2 H. Wang,¹ N. Navarro-Alvarez,¹ Y. Zheng,² Y.-G. Yang.¹
¹Columbia Center for Translational Immunology, Columbia University Medical Center, New York, NY; ²First Hospital, Jilin University, Changchun, Jilin, China.
Background: The interspecies incompatibility of CD47 is an important mechanism triggering rejection of cellular xenografts, including both hematopoietic and non-hematopoietic cells, by recipient macrophages. Our…
2015 American Transplant Congress
Human Bone Marrow Mesenchymal Stem Cell-Derived Hepatocytes Express TIMP-4 and Follistatin
J. Li,¹ J. Xin,¹ W. Ding,² S. Hao,¹ L. Jiang,¹ Q. Zhou,¹ T. Wu,¹ D. Shi,¹ L. Li.¹
¹State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, HangZhou, China; ²Systems Biology Division, Zhejiang-California International Nanosystems Institute, Zhejiang University, HangZhou, China.
Human bone marrow mesenchymal stem cell (hBMSC) transplantation has been expected to be an alternative regenerative technique for liver diseases. However, the mechanism by which…
2015 American Transplant Congress
The Liver X Receptor Alpha (LXRα) Knockout Protect Liver Against Ischemia-Reperfusin Injury in Mice
T. Lu,¹ D. Li,¹ J. Zhang,¹ M. Zhang,¹ X. Cui,¹ H. Dai,¹ X. Liu,² Q. Xia.¹
¹Liver Surgery and Liver Transplantation Center, Renji Hospital, Shanghai, China; ²Cardiovascular, Shanghai First People's Hospital, Shanghai, China.
Background: Liver X Receptor Alpha (LXRα) is a transcription factor crucial for cholesterol, fatty acid, and glucose homeostasis. We hypothesize that LXRαKO may promote hepatocellular…