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American Transplant Congress abstracts

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Articles tagged "Hepatocytes"

  • 2020 American Transplant Congress

    The Therapeutic Potential of Human Liver-Derived Stem Cells Transplantation in Carbon Tetrachloride-Induced Rat Liver Cirrhotic Model

    S. Lee1, J. Lee2, H. Park2, Y. Kim2, S. Lee1

    1Department of Surgery, Samsung Medical Center, Seoul, Korea, Republic of, 2Stem Cell and Regenerative Medicine Center, Research Institute for Future Medicine, Samsung Medical Center, Seoul, Korea, Republic of

    *Purpose: Cirrhosis is a long-term consequence of chronic hepatic injury and there are no effective treatment methods. Mesenchymal stem cells (MSCs) have been reported to…
  • 2020 American Transplant Congress

    Epithelial To Mesenchymal Transition Mediates Engraftment Of Endoderm And Hepatic Progenitor Cells In The Quiescent Liver

    W. S. Fagg1, N. Lui2, L. Patrikeev3, O. Saldarriaga*4, H. Lerner-Stevenson5, V. Popov6, M. Motamade3, J. H. Fair1

    1Surgery, University of Texas Medical Branch, Galveston, TX, 2Surgery, Naiyou Lui, Galveston, TX, 3Ophthalmology, University of Texas Medical Branch, Galveston, TX, 4Pathology, Omar Saldarriaga, Galveston, TX, 5pathology, University of Texas Medical Branch, Galveston, TX, 6Pathology, University of Texas Medical Branch, Galveston, TX

    *Purpose: Stem cell transplantation to the liver is a promising therapeutic strategy for a variety of disorders. Hepatocyte transplantation has short term efficacy, but can…
  • 2020 American Transplant Congress

    Improved Survival of Acute Liver Failure by “Off-the-Shelf” Bioartificial Liver Support System Using Immobilized Cryopreserved Hepatocyte Spheroids in Porcine Model

    S. Lee1, J. Lee2, H. Park2, Y. Kim2, J. Noh3, J. Jung3, S. Lee3, H. Shin3, H. Yoon4, D. Lee3, S. Lee1

    1Department of Surgery, Samsung Medical Center, Seoul, Korea, Republic of, 2Stem Cell and Regenerative Medicine Center, Research Institute for Future Medicine, Samsung Medical Center, Seoul, Korea, Republic of, 3Biomedical Research Center, Lifeliver, Co. Ltd., Yongin, Korea, Republic of, 4Biomedical Research Center, Lifeliver, Co. Ltd., Seoul, Korea, Republic of

    *Purpose: Acute liver failure (ALF) has a rapid and unpredictable onset with high mortality. The only current treatment is to transplant a donor organ but…
  • 2019 American Transplant Congress

    Hepatocyte SIRT1 Modulates ATF4/CHOP and Mitigates Liver Transplant Ischemia-Reperfusion Injury: From Bench-to-Bedside

    H. Hirao1, S. Kageyama1, K. Kadono1, K. Nakamura1, T. Ito1, K. J. Dery1, D. Oncel1, X. Li2, B. Ke1, F. M. Kaldas1, R. W. Busuttil1, J. W. Kupiec‐Weglinski1

    1Surgery, Dumont-UCLA Transplant Center, UCLA, Los Angeles, CA, 2National Institute of Environmental Health Sciences, Research Triangle Park, NC

    *Purpose: We and others have reported on benefits of endoplasmic reticulum (ER) stress modulation against hepatic ischemia-reperfusion injury (IRI) in orthotopic liver transplantation (OLT). Although…
  • 2019 American Transplant Congress

    Glycogen Synthase Kinase 3alpha Serine 21 Phosphorylation Inhibits Hepatocyte Autophagy to Facilitate Liver Ischemia Reperfusion Injury

    M. Ni1, H. Zhou2, R. Busuttil1, J. Kupiec-Weglinski1, X. Wang2, Y. Zhai1

    1Surgery, Dumont-UCLA Transplant Center, Los Angeles, CA, 2Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China

    *Purpose: Glycogen synthase kinase 3 (Gsk3) has α and β isoforms. They are constitutively active in cells and inhibited upon stimulations by N-terminal serine phosphorylation.…
  • 2019 American Transplant Congress

    The Efficacy of Spheroidal Hepatocytes for Hepatocyte Transplantation

    K. Shibuya, M. Watanabe, Y. Ganchiku, R. Kanazawa, Y. Koshizuka, M. Zaitsu, R. Goto, A. Taketomi

    Department of Gastroenterological Surgery Ⅰ Hokkaido University Graduate School, Sapporo, Japan

    *Purpose: Hepatocyte transplantation (HCTx) is expected to expand its application as a next generation therapy alternative to liver transplantation. Following HCTx, the liver function improves…
  • 2019 American Transplant Congress

    Post-Reperfusion Hepatic Beta-Catenin Activation Regulates Graft Damage, Inflammatory Responses and Transplant Outcomes

    H. Hirao, K. Kadono, S. Kageyama, K. Nakamura, T. Ito, J. Aziz, K. J. Dery, F. M. Kaldas, R. W. Busuttil, J. W. Kupiec‐Weglinski

    Dumont-UCLA Transplant Center, UCLA, Los Angeles, CA

    *Purpose: Hepatic ischemia-reperfusion injury (IRI), an innate-immune driven hepatic inflammation response, represents a major risk factor of early allograft dysfunction (EAD) and rejection in liver…
  • 2018 American Transplant Congress

    Type I NKT Cells Augment Humoral and Cellular Alloimmunity in Response to Hepatocyte Transplantation

    S. Elzein, J. Zimmerer, B. Ringwald, C. Avila, G. Bumgardner.

    Surgery, The Ohio State University Wexner Medical Center, Columbus, OH.

    Hepatocyte transplantation (HcTx) is a potential therapeutic modality for patients with liver disease. Despite examples of antigen acceptance in the liver, allogeneic HcTx into patients…
  • 2018 American Transplant Congress

    Rictor mTORC2 Signaling Protects Ischemic Liver Injury by Targeting Both Liver Parenchymal and Non-Parenchymal Cells

    H. Zhou,1 Z. Rao,1 R. Liu,1 S. Zhou,1 J. Rao,1 J. Gu,1 H. Lu,1 Y. Xia,1 X. Wang,1 Y. Zhai,2 L. Lu.1

    1First Affiliated Hospital of Nanjing Medical University, Nanjing, China; 2David Geffen School of Medicine at University of California-Los Angeles, Los Angeles.

    Background and Aims:Mammalian target of rapamycin (mTOR) signaling controls many essential cellular functions. However, the role and its underlying mechanism of Rictor/mTOR complex 2 (mTORC2)…
  • 2018 American Transplant Congress

    Neuropeptide PACAP Protects Hepatocyte against Liver Ischemia/Reperfusion Injury by Promoting Yes-Associated Protein (YAP) Function

    Z. Xue, Y. Liu, C. Zhang, R. Busuttil, J. Kupiec-Weglinski, H. Ji.

    Dept of Surgery, The DumontUCLA Transplant Center, Los Angeles, CA.

    Background: Previously we have demonstrated that neuropeptide pituitary adenylate cyclase-activating polypeptides (PACAP) suppressed local inflammation, and protected liver against IRI by innervating the liver and…
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