Articles tagged "Heart/lung transplantation"

2015 American Transplant Congress
Recipient Myelomonocytic Cells With Activated Hypoxia-Inducible Factor Alleviate Ischemia-Reperfusion Injury in Mouse Heart Allografts
A. Raissadati, M. Keränen, E. Rouvinen, R. Krebs, K. Lemström.
Transplantation Laboratory and Department of Cardiac Surgery, University of Helsinki, Haartman institute and Helsinki University Central Hospital, Heart and Lung Center, Helsinki, Finland.
Aim: To investigate the effect of HIF-1α and -2α activation in myelomonocytic cells during the early phase after ischemia-reperfusion (IRI) injury of mouse allogenic heart…
2015 American Transplant Congress
Identification of CXCR5⁺EBV-Specific CD8⁺ T Cells in Peripheral Blood of Pediatric Heart Transplant Recipients Correlates With IL-21 Production and EBV Reactivation
C. Macedo,¹ K. Hadi,¹ D. Rowe,² J. Luce,³ S. Webber,⁴ B. Feingold,³ D. Metes.¹
¹Thomas E. Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh; ²Infectious Diseases and Microbiology, University of Pittsburgh, Pittsburgh; ³Pediatrics-Cardiology, Children's Hospital of Pittsburgh of UPMC, Pittsburgh; ⁴Pediatrics, Vanderbilt University School of Medicine, Nashville.
Approximately 70% of EBV asymptomatic pediatric heart transplant (HTx) recipients carry chronic EBV loads in peripheral blood. These EBV loads may occur due to impaired…
2015 American Transplant Congress
Examining Long-Term Survivors in Combined Heart-Lung Transplantation
S. Kadakia,¹ S. Jayarajan,¹ S. Taghavi,¹ V. Ambur,¹ C. Lewis,¹ A. Shiose,² G. Wheatley III,² L. Kaiser,³ T. Guy,² Y. Toyoda.²
¹Department of Surgery, Temple University Hospital, Philadelphia, PA; ²Division of Cardiovascular Surgery, Temple University Hospital, Philadelphia, PA; ³Division of Thoracic Surgery, Temple University Hospital, Philadelphia, PA.
The goal of this study was to determine variables associated with mortality in combined heart-lung transplantation (HLT).The United Network for Organ Sharing (UNOS) database was…
2015 American Transplant Congress
Liver Allograft Provides Immunoprotection for the Cardiac Allograft in Combined Heart-Liver Transplantation
T. Wong, J. Stulak, J. Heimbach, M. Stegall, T. Taner.
Mayo Clinic, Rochester, MN.
When transplanted simultaneously, the liver allograft has been thought to have an immunoprotective role on other organs. However, detailed studies on simultaneous heart-liver transplantation (SHLT)…
2015 American Transplant Congress
Allograft Class II MHC and CD40 Expression Are Required for Endogenous Memory CD8 T Cell Proliferation in Cardiac Allografts Subjected to Prolonged Cold Ischemic Storage
T. Tanaka,^1,2 H. Tsuda,^1,3 N. Kohei,^1,4 D. Kish,¹ W. Baldwin,¹ A. Valujskikh,¹ R. Fairchild.¹
¹Immunology, Cleveland Clinic, Cleveland, OH; ²Urology, Sapporo Medical University, Sapporo, Japan; ³Urology, Osaka University, Osaka, Japan; ⁴Urology, Kidney Center, Tokyo Women's Medical University, Tokyo, Japan.
Endogenous memory CD8 T cells infiltrate MHC-mismatched cardiac allografts and produce IFN-γ in response to donor class І MHC within 24 hrs after graft reperfusion…
2015 American Transplant Congress
CD4 T Cell Mediated Help Is Required for Endogenous Memory CD8 T Cell Proliferation in Cardiac Allografts Subjected to Prolonged Cold Ischemic Storage
H. Tsuda,^1,4 T. Tanaka,^2,4 N. Kohei,^3,4 D. Kish,⁴ W. Baldwin,⁴ A. Valujskikh,⁴ R. Fairchild.⁴
¹Advanced Technology for Transplantation, Osaka Univ., Suita, Japan; ²Urology, Sapporo Medical Univ., Sapporo, Japan; ³Urology, Tokyo Women's Medical Univ., Tokyo, Japan; ⁴Immunology, Cleveland Clinic, Cleveland, OH.
Endogenous memory CD8 T cells infiltrate MHC-mismatched cardiac allografts and produce IFN-γ in response to donor class І MHC within 24 hrs after graft reperfusion…