Articles tagged "Heart/lung transplantation"

2015 American Transplant Congress
MicroRNA let-7i Targeting IL-10 Via JAK1-STAT3 Signal Pathway Regulates Dendritic Cells Maturation Subsequently Induces Cardiac Allograft Tolerance
J. Wu,^2,3 X. Jin,¹ Y. Sun,^2,3 X. Liu,^2,3 D. Chi,^2,3 B. Yu.^2,3
¹Thoracic Surgery, The Third Affiliated Hospital of Harbin Medical University, Harbin, China; ²Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, Harbin, China; ³Cardiology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.
Background: Our previous study demonstrated that microRNA (MiR) let-7i could regulate dendritic cells (DCs) maturation and functional state via targeting SOCS1. In this study, we…
2015 American Transplant Congress
Targeted Silencing of TLR Adaptor Genes Using Mannose Liposome to Prolong Cardiac Allograft Survival
X. Zhang,¹ J. Jiang,² X. Zheng,¹ J. Shi,³ T. Zwiep,¹ N. Johnston,¹ D. Quan,^1,2 W.-P. Min.^1,2,3
¹Department of Surgery, Pathology and Oncology, Western University, London, ON, Canada; ²Multi-Organ Transplant Program, London Health Sciences Centre, London, ON, Canada; ³Jiangxi Academy of Medical Sciences, The First Affiliated Hospital, and Institute of Immunotherapy of Nanchang, NanChang, Jiangxi, China.
Background: MyD88 and TRIF, the common adaptors of Toll-like receptors (TLRs) signaling, evoke dendritic cells (DCs)-mediated antigen-specific immune rejection. Abolish TLR-induced adaptive immune response in…
2015 American Transplant Congress
Upregulation of Heart Transplant IL-33 Is Critical in Cardiac Tissue Repair
Q. Liu, L. Mathews, J. Lott, B. Matta, H. Turnquist.
Starzl Transplantation Institute, Department of Surgery, Univ of Pittsburgh, Pittsburgh, PA.
Background: IL-33 is tissue-derived cytokine whose primary proposed function is to modulate immune responses when released during injury. Delivery of recombinant IL-33 protects cardiac allografts…
2015 American Transplant Congress
Factors Influencing Cost Among Kidney, Liver, and Heart Transplant Patients in a Private Payer Setting
W. Bannister,¹ C. Wu,¹ M. Schnitzler,² F. Irwin,¹ A. Bonagura.¹
¹Optum, Minneapolis; ²Saint Louis University, St. Louis.
The factors influencing cost in solid organ transplantation have been evaluated by many individual centers, as well as nationally for Medicare patients. However, the majority…
2015 American Transplant Congress
Induction of HO-1 High Expression Enhances the Capacity of Immature Dendritic Cells to Modulate Alloimmune Responses
G. Chen, Y. Zhao, L. Wang, S. Chen, X. Huang.
Institute of Organ Transplantation, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Background: It has been reported that HO-1 is critical for tolerogenic dendritic cells (tolDCs) to suppress T cell responses and tolDCs will lost their immunoregulatory…
2015 American Transplant Congress
Murine Veno-Arterial Extracorporeal Membrane Oxygenation (mVA-ECMO): A Novel Tool to Study the Molecular Biology of Mechanical Circulatory Support
A. Schenk,¹ J. Fallon,¹ M. Farrell,¹ R. Halter,² J. Yun.³
¹Surgery, Dartmouth Hitchcock Medical Center, Lebanon, NH; ²Thayer School of Engineering, Dartmouth College, Hanover, NH; ³Cardiothoracic Surgery, Yale New-Haven Hospital, New Haven, CT.
PURPOSE: In recent years, clinical use of veno-arterial extracorporeal membrane oxygenation (VA-ECMO) has grown. Extracorporeal circulation is an essential component of heart and lung transplantation,…