Articles tagged "Heart/lung transplantation"

2015 American Transplant Congress
Allograft Class II MHC and CD40 Expression Are Required for Endogenous Memory CD8 T Cell Proliferation in Cardiac Allografts Subjected to Prolonged Cold Ischemic Storage
T. Tanaka,^1,2 H. Tsuda,^1,3 N. Kohei,^1,4 D. Kish,¹ W. Baldwin,¹ A. Valujskikh,¹ R. Fairchild.¹
¹Immunology, Cleveland Clinic, Cleveland, OH; ²Urology, Sapporo Medical University, Sapporo, Japan; ³Urology, Osaka University, Osaka, Japan; ⁴Urology, Kidney Center, Tokyo Women's Medical University, Tokyo, Japan.
Endogenous memory CD8 T cells infiltrate MHC-mismatched cardiac allografts and produce IFN-γ in response to donor class І MHC within 24 hrs after graft reperfusion…
2015 American Transplant Congress
CD4 T Cell Mediated Help Is Required for Endogenous Memory CD8 T Cell Proliferation in Cardiac Allografts Subjected to Prolonged Cold Ischemic Storage
H. Tsuda,^1,4 T. Tanaka,^2,4 N. Kohei,^3,4 D. Kish,⁴ W. Baldwin,⁴ A. Valujskikh,⁴ R. Fairchild.⁴
¹Advanced Technology for Transplantation, Osaka Univ., Suita, Japan; ²Urology, Sapporo Medical Univ., Sapporo, Japan; ³Urology, Tokyo Women's Medical Univ., Tokyo, Japan; ⁴Immunology, Cleveland Clinic, Cleveland, OH.
Endogenous memory CD8 T cells infiltrate MHC-mismatched cardiac allografts and produce IFN-γ in response to donor class І MHC within 24 hrs after graft reperfusion…
2015 American Transplant Congress
Inhibition of RhoA Pathway-Related Macrophage Functions Abrogates Chronic Rejection of Cardiac Allograft
M. Kloc, J. You, N. Tejpal, X. Li, R. Ghobrial.
TMHRI, Houston, TX.
Objective. Chronic rejection remains the main obstacle in the long-term success of organ transplantation. The long-term survival of allografted hearts is limited by a progressive…
2015 American Transplant Congress
Role of Innate Immune Cells in Chronic Allograft Loss and Novel Strategies to Target Them
C. Wu,^1,2 P. Zhao,¹ W. Liu,¹ X. Xiao,¹ X. Shi,¹ Y. Peng,¹ M. Kloc,¹ X. He,² M. Ghobrial,¹ X. Li.¹
¹Center for Immunobiology and Transplantation Research, Houston Methodist Hospital and Houston Methodist Research Institute, Houston, TX; ²Organ Transplant Center, 1st Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, China.
Despite remarkable improvements in short term transplant survival, the long-term outcome of allografts remains poor in the clinic, and most transplants are eventually lost due…
2015 American Transplant Congress
MicroRNA let-7i Targeting IL-10 Via JAK1-STAT3 Signal Pathway Regulates Dendritic Cells Maturation Subsequently Induces Cardiac Allograft Tolerance
J. Wu,^2,3 X. Jin,¹ Y. Sun,^2,3 X. Liu,^2,3 D. Chi,^2,3 B. Yu.^2,3
¹Thoracic Surgery, The Third Affiliated Hospital of Harbin Medical University, Harbin, China; ²Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, Harbin, China; ³Cardiology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.
Background: Our previous study demonstrated that microRNA (MiR) let-7i could regulate dendritic cells (DCs) maturation and functional state via targeting SOCS1. In this study, we…
2015 American Transplant Congress
Targeted Silencing of TLR Adaptor Genes Using Mannose Liposome to Prolong Cardiac Allograft Survival
X. Zhang,¹ J. Jiang,² X. Zheng,¹ J. Shi,³ T. Zwiep,¹ N. Johnston,¹ D. Quan,^1,2 W.-P. Min.^1,2,3
¹Department of Surgery, Pathology and Oncology, Western University, London, ON, Canada; ²Multi-Organ Transplant Program, London Health Sciences Centre, London, ON, Canada; ³Jiangxi Academy of Medical Sciences, The First Affiliated Hospital, and Institute of Immunotherapy of Nanchang, NanChang, Jiangxi, China.
Background: MyD88 and TRIF, the common adaptors of Toll-like receptors (TLRs) signaling, evoke dendritic cells (DCs)-mediated antigen-specific immune rejection. Abolish TLR-induced adaptive immune response in…