Articles tagged "Heart/lung transplantation"

2015 American Transplant Congress
Targeted Silencing of TLR Adaptor Genes Using Mannose Liposome to Prolong Cardiac Allograft Survival
X. Zhang,¹ J. Jiang,² X. Zheng,¹ J. Shi,³ T. Zwiep,¹ N. Johnston,¹ D. Quan,^1,2 W.-P. Min.^1,2,3
¹Department of Surgery, Pathology and Oncology, Western University, London, ON, Canada; ²Multi-Organ Transplant Program, London Health Sciences Centre, London, ON, Canada; ³Jiangxi Academy of Medical Sciences, The First Affiliated Hospital, and Institute of Immunotherapy of Nanchang, NanChang, Jiangxi, China.
Background: MyD88 and TRIF, the common adaptors of Toll-like receptors (TLRs) signaling, evoke dendritic cells (DCs)-mediated antigen-specific immune rejection. Abolish TLR-induced adaptive immune response in…
2015 American Transplant Congress
Upregulation of Heart Transplant IL-33 Is Critical in Cardiac Tissue Repair
Q. Liu, L. Mathews, J. Lott, B. Matta, H. Turnquist.
Starzl Transplantation Institute, Department of Surgery, Univ of Pittsburgh, Pittsburgh, PA.
Background: IL-33 is tissue-derived cytokine whose primary proposed function is to modulate immune responses when released during injury. Delivery of recombinant IL-33 protects cardiac allografts…
2015 American Transplant Congress
Factors Influencing Cost Among Kidney, Liver, and Heart Transplant Patients in a Private Payer Setting
W. Bannister,¹ C. Wu,¹ M. Schnitzler,² F. Irwin,¹ A. Bonagura.¹
¹Optum, Minneapolis; ²Saint Louis University, St. Louis.
The factors influencing cost in solid organ transplantation have been evaluated by many individual centers, as well as nationally for Medicare patients. However, the majority…
2015 American Transplant Congress
Induction of HO-1 High Expression Enhances the Capacity of Immature Dendritic Cells to Modulate Alloimmune Responses
G. Chen, Y. Zhao, L. Wang, S. Chen, X. Huang.
Institute of Organ Transplantation, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Background: It has been reported that HO-1 is critical for tolerogenic dendritic cells (tolDCs) to suppress T cell responses and tolDCs will lost their immunoregulatory…
2015 American Transplant Congress
Murine Veno-Arterial Extracorporeal Membrane Oxygenation (mVA-ECMO): A Novel Tool to Study the Molecular Biology of Mechanical Circulatory Support
A. Schenk,¹ J. Fallon,¹ M. Farrell,¹ R. Halter,² J. Yun.³
¹Surgery, Dartmouth Hitchcock Medical Center, Lebanon, NH; ²Thayer School of Engineering, Dartmouth College, Hanover, NH; ³Cardiothoracic Surgery, Yale New-Haven Hospital, New Haven, CT.
PURPOSE: In recent years, clinical use of veno-arterial extracorporeal membrane oxygenation (VA-ECMO) has grown. Extracorporeal circulation is an essential component of heart and lung transplantation,…
2015 American Transplant Congress
Anti-BTLA Antibody (6B2) Induced Prolongation of Fully MHC-Mismatched Murine Cardiac Allograft and Generation of Foxp3+ Regulatory T Cells
M. Uchiyama,^1,2,3 E. Yin,^3,4 X. Jin,^3,5 T. Shimokawa,¹ H. Yagita,² M. Niimi.³
¹Cardiovascular Surgery, Teikyo University, Tokyo, Japan; ²Immunology, Juntendo University Hospital, Tokyo, Japan; ³Surgery, Teikyo University, Tokyo, Japan; ⁴Cardiovascular Surgery, The 2nd Affiliated Hospital of Harbin Medical University, Harbin, China; ⁵Cardiovascular and Thoracic Surgery, The 4th Affiliated Hospital of Harbin Medical University, Harbin, China.
Background: The co-inhibitory receptor B and T lymphocyte attenuator (BTLA; CD272) has been implicated in the regulation of autoimmune and may potentially play an important…
2015 American Transplant Congress
Indefinite Survival of Fully MHC-Mismatched Murine Cardiac Allografts by Combination of Anti-BTLA mAb (6B2) and Anti-PD-1 mAb (PIM-2)
E. Yin,^1,2 M. Uchiyama,^1,3,4 X. Jin,^1,5 T. Shimokawa,³ H. Yagita,⁴ M. Niimi.¹
¹Department of Surgery, Teikyo University, Tokyo, Japan; ²Department of Cardiovascular Surgery, The 2nd Affiliated Hospital of Harbin Medical University, Harbin, China; ³Department of Cardiovascular Surgery, Teikyo University, Tokyo, Japan; ⁴Department of Immunology, Juntendo University Hospital, Tokyo, Japan; ⁵Department of Cardiovascular and Thoracic Surgery, The 4th Affiliated Hospital of Harbin Medical University, Harbin, China.
Background: The co-inhibitory receptor B and T lymphocyte attenuator (BTLA) and Programmed death (PD)-1 had been suggested to have immunomodulatory activity. This study investigated the…
2015 American Transplant Congress
Recipient Myelomonocytic Cells With Activated Hypoxia-Inducible Factor Alleviate Ischemia-Reperfusion Injury in Mouse Heart Allografts
A. Raissadati, M. Keränen, E. Rouvinen, R. Krebs, K. Lemström.
Transplantation Laboratory and Department of Cardiac Surgery, University of Helsinki, Haartman institute and Helsinki University Central Hospital, Heart and Lung Center, Helsinki, Finland.
Aim: To investigate the effect of HIF-1α and -2α activation in myelomonocytic cells during the early phase after ischemia-reperfusion (IRI) injury of mouse allogenic heart…
2015 American Transplant Congress
Identification of CXCR5⁺EBV-Specific CD8⁺ T Cells in Peripheral Blood of Pediatric Heart Transplant Recipients Correlates With IL-21 Production and EBV Reactivation
C. Macedo,¹ K. Hadi,¹ D. Rowe,² J. Luce,³ S. Webber,⁴ B. Feingold,³ D. Metes.¹
¹Thomas E. Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh; ²Infectious Diseases and Microbiology, University of Pittsburgh, Pittsburgh; ³Pediatrics-Cardiology, Children's Hospital of Pittsburgh of UPMC, Pittsburgh; ⁴Pediatrics, Vanderbilt University School of Medicine, Nashville.
Approximately 70% of EBV asymptomatic pediatric heart transplant (HTx) recipients carry chronic EBV loads in peripheral blood. These EBV loads may occur due to impaired…
2015 American Transplant Congress
Examining Long-Term Survivors in Combined Heart-Lung Transplantation
S. Kadakia,¹ S. Jayarajan,¹ S. Taghavi,¹ V. Ambur,¹ C. Lewis,¹ A. Shiose,² G. Wheatley III,² L. Kaiser,³ T. Guy,² Y. Toyoda.²
¹Department of Surgery, Temple University Hospital, Philadelphia, PA; ²Division of Cardiovascular Surgery, Temple University Hospital, Philadelphia, PA; ³Division of Thoracic Surgery, Temple University Hospital, Philadelphia, PA.
The goal of this study was to determine variables associated with mortality in combined heart-lung transplantation (HLT).The United Network for Organ Sharing (UNOS) database was…