Articles tagged "Heart/lung transplantation"

2019 American Transplant Congress
Reference Ranges Donor-Derived Cell-Free DNA in a Heart Transplant Population
A. Kao¹, S. Dholakia², M. Deng³
¹Saint Luke's, Kansas City, MO, ²CareDx, Brisbane, CA, ³University of Los Angeles, Los Angeles, CA
*Purpose: Elevations in donor-derived cell-free DNA (dd-cfDNA) ≥0.20 % in heart transplant recipients (HTR) has been shown to be associated with a probability of acute…
2019 American Transplant Congress
Exercise for Solid Organ Transplant Candidates and Recipients: A Joint Position Statement of the Canadian Society of Transplantation (CST) and Canadian Network for Rehabilitation and Exercise for Solid Organ Transplant Optimal Recovery (CAN-RESTORE)
T. Janaudis-Ferreira¹, S. Mathur², R. Deliva³, N. Howes⁴, C. Patterson⁵, A. Räkel⁶, S. So⁵, L. Wickerson⁷, M. White⁶, Y. Avitzur⁵, O. Johnston⁸, N. Heywood⁹, S. Singh⁷, S. Holdsworth¹⁰
¹School of Physical and Occupational Therapy, McGill University, Montreal, QC, Canada, ²University of Toronto, Toronto, ON, Canada, ³The Hospital for Sick Children, Toronto, ON, Canada, ⁴London Health Sciences Centre, London, ON, Canada, ⁵The Hospital For Sick Children, Toronto, ON, Canada, ⁶University of Montreal Hospital Centre, Montreal, QC, Canada, ⁷University Health Network, Toronto, ON, Canada, ⁸Vancouver General Hospital, Vancouver, BC, Canada, ⁹McGill University Health Centre, Montreal, QC, Canada, ¹⁰Canadian Donation and Transplantation Research Program, Edmonton, AB, Canada
*Purpose: Exercise training has been shown to be beneficial across several chronic disease groups that may lead to solid organ transplantation (SOT), and across organ…
2019 American Transplant Congress
Dendritic Cells Transduced with Autoimmune Regulator Exhibit Immature Properties and Prolong Heart Allograft Survival
Y. Zhang, Z. Zhu, M. Chen, S. Huang, C. Sun, W. Ju, Z. Guo, X. He
Organ Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
*Purpose: The expression of the Aire (Autoimmune regulator) gene was observed to inhibit the maturation and activation of dendritic cells (DCs) and induce transplantation tolerance.*Methods:…
2019 American Transplant Congress
Is Muscular Dystrophy A Contraindication To Heart Transplantation?
M. Kittleson, J. Patel, D. H. Chang, S. Dimbil, R. Levine, L. Czer, J. A. Kobashigawa
Cedars-Sinai Smidt Heart Institute, Los Angeles, CA
*Purpose: Patients with muscular dystrophy may have an associated cardiomyopathy, resulting in advanced heart failure requiring transplantation. However, the skeletal muscle dysfunction can result in…
2019 American Transplant Congress
Correlation between Self-Reported Medication Adherence and Side Effects in Cardiothoracic Transplant Recipients
T. Harrison¹, N. Patel¹, H. Corbo¹, K. Foster¹, H. Meadows¹, N. Pilch¹, C. Perez¹, J. Fleming¹, D. Judge², L. Paoletti³, D. Taber¹
¹Pharmacy Services, Medical University of South Carolina, Charleston, SC, ²Cardiology, Medical University of South Carolina, Charleston, SC, ³Pulmonary & Critical Care Medicine, Medical University of South Carolina, Charleston, SC
*Purpose: Medication non-adherence (MNA) is a major risk factor for acute rejection and graft loss. It is unclear how medication side effects (SE) and perceived…
2019 American Transplant Congress
Simulated Tier Variability
N. Salkowski, A. Wey, J. Snyder
SRTR, Minneapolis, MN
*Purpose: The Scientific Registry of Transplant Recipients semi-annually assigns transplant programs to one of five performance tiers for 1-year graft survival in its program-specific reports…
2019 American Transplant Congress
Gene Expression Profiling for Cardiac Transplant Recipients: Results from the Outcomes AlloMap® Registry
S. Hall¹, G. Ewald², P. Berman³, A. Kao⁴, T. Wolf-Doty⁵, J. Yee⁵, J. Kobashigawa⁶
¹Baylor University Medical Center, Dallas, TX, ²Washington University, St. Louis, MO, ³Tampa General Hospital, Tampa, FL, ⁴Saint Luke's Mid America Heart Institute, Kansas City, MO, ⁵CareDx, Brisbane, CA, ⁶Cedars-Sinai Medical Center, Los Angeles, CA
*Purpose: Transplant registries may facilitate collection of comprehensive and unbiased real-world data on short and long-term outcomes of patients. We share the results of patients…
2019 American Transplant Congress
The Impact of Acute Rejection in Heart Transplantation on Post-Transplant Malignancy
K. Kamrani¹, A. Okoh², D. Hanos¹, M. Camacho¹, M. Zucker², K. Clarke¹
¹Dept. of Surgery, Newark Beth Israel Medical Center, Newark, NJ, ²Dept. of Medicine, Newark Beth Israel Medical Center, Newark, NJ
*Purpose: Compared with the general population, an increased incidence of skin cancers and lymphomas have been shown in orthotopic heart transplant (OHT) recipients. However, the…
2018 American Transplant Congress
The Continuous Debate of Older Donors into Older Recipients: Another Angle
J. Patel, M. Kittleson, E. Kransdorf, S. Dimbil, R. Levine, D. Geft, D. Chang, L. Czer, J. Kobashigawa.
Cedars Sinai Medical Center, Los Angeles.
Purpose: Heart transplantation (HTx) remains limited by donor availability. Many programs accept older donors (≥50 yrs) for older recipients (≥ 60 yrs) in an effort…
2018 American Transplant Congress
Senolytic Drug Treatment Attenuates mtDNA-Mediated Inflammatory Injury in Old Donors and Prolongs Cardiac Allograft Survival
K. Minami,¹ M. Seyda,¹ T. Heinbokel,¹ Y. Nian,¹ M. Quante,¹ G. Liu,¹ R. Abdi,² T. Tchkonia,³ J. Kirkland,³ A. Elkhal,¹ S. Tullius.¹
¹Transplant Surgery Division, Department of Surgery, Brigham and Women's Hospital, Boston, MA; ²Transplantation Research Center, Brigham and Women's Hospital, Boston; ³Robert and Arlene Kogod Center on Aging, Mayo Clinic College of Medicine, Rochester, MN.
Introduction: Solid organ transplantation has seen a increase in the utilization of older organs. Here, we investigate how aging-associated kinetics of damage associated molecular patterns…