Articles tagged "Heart/lung transplantation"

2019 American Transplant Congress
Intravenous Methamphetamine Does Not Appear To Be A Contraindication For Heart Donation In Heart Transplantation
A. Velleca, J. Patel, M. Kittleson, R. Levine, S. Dimbil, S. Mersola, M. Hamilton, F. Esmailian, J. A. Kobashigawa
Cedars-Sinai Smidt Heart Institute, Los Angeles, CA
*Purpose: Intravenous methamphetamine (IV meth) use in potential heart donors has been of concern due to the possibility of methamphetamine cardiomyopathy and transmission of infections.…
2019 American Transplant Congress
Perioperative Cardiac Xenograft Dysfunction after Orthotopic Transplantation is for Real
M. Mohiuddin¹, A. Singh¹, L. DiChiacchio¹, D. Kaczorowski¹, B. Lewis¹, T. Zhang¹, F. Sentz¹, I. Tatarov¹, D. Parsell¹, P. Odonkor¹, E. Strauss¹, B. Williams¹, K. Deatrick¹, D. Ayares², B. Griffith¹, S. Bartlett¹
¹Department of Surgery, University of Maryland Baltimore, Baltimore, MD, ²Revivicor, Inc, Blacksburg, VA
*Purpose: After successful prolongation of cardiac xenograft survival in a heterotopic position, the next step is to evaluate genetically engineered (GE) pig hearts for their…
2019 American Transplant Congress
IL-1β and IL-6 Facilitate T Cell Reconstitution in Heart Allograft Recipients Treated with Anti-Thymocyte Globulin
S. Hasgur, R. Fan, A. Valujskikh
Inflammation and Immunity, Cleveland Clinic, Cleveland, OH
*Purpose: Antibody-mediated lymphocyte depletion is used in solid organ and stem cell transplantation. However, T cell reconstitution after lymphoablation may lead to acute rejection and…
2019 American Transplant Congress
Anti-Complement Component 5 Antibody Based Immunosuppression Induced Accommodation in ABO Incompatible Heart Transplantation
S. Park¹, S. Lee¹, J. Hwang¹, J. Ryu², T. Koo², C. Ahn³, J. Yang⁴
¹Biomedical Research Institute, Seoul National University Hospital, Seoul, Korea, Republic of, ²Transplantation Center, Seoul National University Hospital, Seoul, Korea, Republic of, ³Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea, Republic of, ⁴Department of Surgery, Seoul National University Hospital, Seoul, Korea, Republic of
*Purpose: Plasmapheresis in combination with immunoglobulin and rituximab is often used to induce accommodation in ABO-incompatible (ABOi) living-donor transplantation; however, this regimen cannot be applied…
2019 American Transplant Congress
Heart-Associated Cytokine and Endothelial Patterns Dominate the Ischemia/Reperfusion Response in Recipients of Combined Heart/Lung Transplantation in Comparison to Lung Transplantation
F. Wandrer¹, B. Wiegmann², N. Ledwoch¹, R. Bellmas Sanz¹, F. Ius², W. Sommer², S. Rojas², C. Kühn², I. Tudorache², M. Avsar², A. Haverich², G. Warnecke², C. S. Falk¹
¹Institute of Transplant Immunology, Hannover Medical School, Hannover, Germany, ²Department for Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School, Hannover, Germany
*Purpose: Organ-specific differences are discussed for ischemia/reperfusion injury (IRI) in cardiothoracic transplantation (Tx) but rarely compared directly in a clinical setting. Therefore, we compared a…
2019 American Transplant Congress
Treprostinil as a Bridge Therapy to Heart-Lung Transplants with Severe Pulmonary Arterial Hypertension
C. Ju, Q. Lian, B. Wei, X. Xu, J. He, R. Chen
State Key Lab of the Respiratory Disease, Guangzhou Institute of Respiratory Disease, Guangzhou, China
*Purpose: Heart-lung transplants (HLTx) is the only one effective strategy for advanced pulmonary arterial hypertension (PAH) with refractory right heart failure. But limited availability of…
2019 American Transplant Congress
Characterization of Intra-Exosomal Cargoes of Circulating Donor Heart Specific Exosomes in Murine Heart Transplantation Model
J. Harmon, V. Korutla, L. Korutla, R. Hu, S. Rostami, A. Habertheuer, P. Zielinski, A. Freas, C. Ram, A. Naji, M. Davis, P. Vallabhajosyula
Department of Surgery, University of Pennsylvania, Philadelphia, PA
*Purpose: Exosomes are tissue specific, bilayered, membrane-bound nanoparticles released by many types of cells into bodily fluids including blood and urine. Exosomes carry protein and…
2019 American Transplant Congress
Pre-Transplant Patient and Caregiver Assessments: A Systematic Review and Meta-Analysis
J. Lau, A. A. Rmilah, R. Mendpara, P. J. Erwin, C. C. Kennedy
Mayo Clinic, Rochester, MN
*Purpose: We sought to summarize the available literature regarding the psychosocial effects of the waiting period on pre-transplant adult heart or lung transplant candidates and…
2018 American Transplant Congress
Superior Renal Function with CNI-Free Everolimus over Standard CNI-Based Regimen: 18 Months Data from the Randomized, Multi-Center MANDELA Trial in De Novo Heart Transplant Recipients
M. J. Barten,¹ S. W. Hirt,¹ J. Garbade,¹ C. Bara,¹ A. Doesch,¹ C. Knosalla,¹ C. Grinninger,¹ J. Stypmann,¹ C. Sieder,² M. Junge,² U. Schulz.¹
¹Mandela Study Group, Germany; ²Novartis, Pharma, Germany.
Purpose: The MANDELA study (NCT00862979) was designed to assess the benefit on renal function of either CNI-free or CNI-minimized EVR-based regimen after early conversion of…
2018 American Transplant Congress
Late Donor-Specific Antibody (Especially Class II) Development is Associated with an Increased Risk for Cardiac Allograft Vasculopathy
E. Kransdorf, J. Patel, M. Kittleson, R. Levine, S. Dimbil, D. Geft, D. Chang, L. Czer, J. Kobashigawa.
Cedars Sinai Medical Center, Los Angeles.
Purpose: Development of donor-specific antibodies (DSA) following heart transplantation (HTx) impacts rejection, cardiac allograft vasculopathy (CAV), and survival. In addition, the timing of Ab development…