2019 American Transplant Congress
Slowed Progression of Maximal Intimal Thickening by Intravascular Ultrasound after Initiation of Sirolimus
1Children's Hospital Colorado, Aurora, CO, 2University of Florida Health, Gainesville, FL
*Purpose: Evidence in adult heart transplant (HT) patients (pt) shows that initiating sirolimus (SRL) slows progression of cardiac allograft vasculopathy (CAV) measured by intravascular ultrasound…2019 American Transplant Congress
A Novel Protocol to Produce Massive Amounts of Autologous Thymus-Derived Treg Cells (ThyTreg) to Be Employed as Cellular Therapy in Heart Transplanted Children: A New Paradigm for the Prevention of Graft Rejection
*Purpose: Immune allograft rejection remains the main obstacle to successful transplants. Although transfer of regulatory T cells (Treg) has acquired growing interest in achieving indefinite…2019 American Transplant Congress
Geographic Disparities in Heart Transplant Rates
*Purpose: One of the motivations for the recent changes to the heart allocation policy was to reduce geographic disparities. We investigated whether heart transplant (HT)…2019 American Transplant Congress
Do Heart Transplant Patients Have Support Personnel Ready to Help Them If Necessary?
Cedars-Sinai Smidt Heart Institute, Los Angeles, CA
*Purpose: After heart transplantation (HTx), we mandate that each patient have social support in the first several weeks. It is not known whether these support…2019 American Transplant Congress
Heart En Bloc Thymus Cotransplantation in NHPs
*Purpose: Tolerance of isolated cardiac allografts has never been achieved in NHPs. We investigated whether a cotransplanted, vascularized, donor thymus could induce tolerance of a…2019 American Transplant Congress
Risk Factors to Define an Extended Criteria Donor Heart Do Not Appear to Have Cumulative Adverse Effects after Heart Transplantation
Cedars-Sinai Smidt Heart Institute, Los Angeles, CA
*Purpose: There remains a disparity between the number of patients awaiting heart transplantation (HTx) and the availability of donor hearts. This is exacerbated by relatively…2019 American Transplant Congress
Infectious Risk of Rejection Therapy Following Heart Transplantation; Can It Be Avoided?
Cedars-Sinai Smidt Heart Institute, Los Angeles, CA
*Purpose: The diagnosis of rejection after heart transplantation (HTx) is usually based on the surveillance endomyocardial biopsies (EMB). These protocol biopsies are performed at scheduled…2019 American Transplant Congress
Circulating Exosomes with Cardiac Self-Antigens (Cardiac Myosin and Vimentin) and De Novo Development of Antibodies to Cardiac Self-Antigens Precedes Chronic Cardiac Allograft Rejection
Norton Thoracic Institute, St. Joseph’s Hospital and Medical Center, Phoenix, AZ
*Purpose: The aim of the study is to determine the kinetics of induction of circulating exosomes with cardiac self-antigens (SAgs), cardiac myosin (MYO) and Vimentin…2019 American Transplant Congress
p40 Homodimer Indirectly Induce Proliferation of Endogenous Donor-Reactive Memory CD8 T Cells within High-Risk Allografts via IL-15 Signaling
Inflammation and Immunity, Cleveland Clinic, Cleveland, OH
*Purpose: Increasing the duration of cold ischemic storage (CIS) from 0.5 to 8 hrs prior to transplant induces the increased proliferation of endogenous donor-reactive CD4…2019 American Transplant Congress
Extracorporeal Photopheresis for Specific Immune Tolerance Responses in Heart Transplant Recipients
*Purpose: Extracorporeal photopheresis (ECP) treatment following heart transplantation (HTx) may induce transplant tolerance. A monitoring tool for successful ECP treatment would allow determination of patient-specific…
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