Articles tagged "Heart"

2015 American Transplant Congress
Kidney Plasmacytoid Dendritic Cells Display Distinct Cell Surface Markers and May Explain the Induction of Tolerance by Kidney Allografts
N. Oh, M. Tonsho, D. Ndishabandi, R. Colvin, J. Madsen, A. Alessandrini.
Massachusetts General Hospital, Boston, MA.
Achieving tolerance in heart allografts is an important area of research as the need for heart transplantations increase. Recent studies in non-human primates (NHPs) have…
2015 American Transplant Congress
CXCR4-SDF1α Blockade Reduces the Severity of Murine Heart Allograft Rejection
X. Wang,¹ J. Fu,¹ B. Wilde,¹ L. Jing,¹ J. Zhu,¹ A. Kribben,¹ O. Witzke,¹ A. Hoerning.^2,3
¹Department of Nephrology, University Hospital Essen, University Duisburg-Essen, Essen, Germany; ²Department of Pediatrics II, University Hospital Essen, University Duisburg-Essen, Essen, Germany; ³Department of Pediatric and Adolescent Medicine, University Hospital Erlangen, Friedrich-Alexander University Erlangen, Erlangen, Germany.
Introduction: The interaction of the CXCR4/SDF1α axis plays a critical role in the retention of hematopoietic stem cells in bone marrow. We hypothesized that the…
2015 American Transplant Congress
Complement Inhibition Via the Lectin Pathway Improves Experimental Cardiac Graft Survival
J. Kindermann,^1,2 M. Waechter,^1,2 R. Bruno,¹ M. Langenmayer,³ T. Dudler,⁴ W. Schwaeble,⁵ E. Kleinert,¹ T. Mayr,^1,2 H. Christian,² R. Wanke,³ J.-M. Abicht,⁶ S. Guethoff.¹
¹Transregio Collaborative Research Center 127, Ludwig-Maximilians University, Munich, Germany; ²Department of Cardiac Surgery, Ludwig-Maximilians University, Munich, Germany; ³Institute of Veterinary Pathology, Ludwig-Maximilians University, Munich, Germany; ⁴Omeros Corporation, Seattle, WA; ⁵Department of Infection, Immunity, and Inflammation, Leicester University, Leicester, United Kingdom; ⁶Department of Anaesthesiology, Ludwig-Maximilians University, Munich, Germany.
Purpose: While complement activation via both the classical as well as the lectin pathway is believed to contribute to allograft loss, their relative contribution is…