2016 American Transplant Congress
Recapitulating Peripheral T Cell Development in Neonatal Mice to Induce Transplant Tolerance.
University of Alberta, Edmonton, Canada.
Purpose: Neonatal mice are susceptible to tolerance induction with semi-allogeneic bone marrow and spleen cells (BMC/SC) while allogeneic BMC/SC cause acute lethal graft-versus-host disease (GVHD).…2016 American Transplant Congress
Cold Storage Stabilization of Gap Junctions Reduces Post Transplant Ischemia Reperfusion Injury.
Purpose: Organ procurement, cold storage and ischemia reperfusion injury (IRI) promote inflammation, which induces endothelial cell (EC) activation and dysfunction post transplantation. EC gap junctions…2016 American Transplant Congress
Rapamycin Prolongs Cardiac Allograft Survival in a Mouse Model by Inducing Myeloid-Derived Suppressor Cells.
Mammalian target of rapamycin (mTOR) inhibitors are the main immunosuppressive drugs for organ transplant recipients. Nevertheless, the mechanisms by which mTOR inhibitors induce immunosuppression is…2016 American Transplant Congress
Thoracic Simulation Allocation Modeling (TSAM) of a 6-Tier Allocation Strategy.
Heart allocation policy (OPTN policy 6) is in development. To stratify medical urgency, the Heart Subcommittee of the OPTN Thoracic Committee developed a 6-tier algorithm…2016 American Transplant Congress
Medicaid Insurance Is Associated with Shorter Time to Transplant Listing After LVAD Implantation.
Emory University School of Medicine, Atlanta, GA.
Introduction: Left-ventricular assist devices (LVAD) and total artificial hearts (TAH) are being increasingly utilized as a bridge to heart transplant (HT). Prior studies have demonstrated…2016 American Transplant Congress
Pre-Transplant Coronary Artery Disease: An Underestimated Risk Factor for Post-Transplant Mortality?
Nephrology, Charite Universitaetsmedizin, Berlin, Germany.
Background: Coronary artery disease is a frequent comorbidity among transplant candidates. Limited data exist on the long-term outcomes of kidney transplant recipients (KTR) with pre-existing…2015 American Transplant Congress
Effects of Heart and Lung Co-Transplantation Across a Full MHC Barrier in Miniature Swine
Background: We have previously shown that tolerance of heart allografts across a full MHC barrier can be induced in miniature swine after a 12-day course…2015 American Transplant Congress
Cell Type of the Tolerizing Inoculum Plays a Role in the Formation of of Molecular Chimerism in Murine Neonatal Tolerance
Background: Heart transplantation is a lifesaving measure for many infants with severe congenital heart diseases. The acceptance of cardiac allografts without immunosuppression, or operational tolerance,…2015 American Transplant Congress
Acute Kidney Injury and Outcome After Cardiac Transplantation
Background:Chronic kidney disease (CKD) is a frequently seen complication after cardiac transplantation and is partly explained by the prolonged use of calcineurin inhibitors. However, few…2015 American Transplant Congress
Donor Dendritic Cells – Potential New Therapeutic Target in Transplantation
Background: It is clear that T cells play a central role in the process of allograft rejection. However, donor dendritic cells (dDC) are the most…
American Transplant Congress abstracts