2017 American Transplant Congress
Clinical Correlation of Endomyocardial Biopsies Molecular Profiling: Taking Rejection Diagnosis Beyond Histology.
Histology grading of endomyocardial biopsies (EMB), the standard for diagnosing T-cell-mediated (TCMR) and antibody-mediated (ABMR) rejection, has serious issues with reproducibility (Transplantation 94 (11):1172177, 2012)…2017 American Transplant Congress
CD4 and CD8 T Cells: Respectively Reprogrammed and Recapitulated in the Neonate to Induce Transplant Tolerance.
Alberta Transplant Institute, University of Alberta, Edmonton, Canada
Purpose: Non-conditioned neonatal mice develop acute graft-versus-host disease (aGVHD) when injected with adult allogeneic spleen and bone marrow cells (allo-SC/BMC). To prevent aGVHD and induce…2017 American Transplant Congress
Validation of a Prediction Model for Cardiac Allograft Vasculopathy.
Cedars-Sinai Heart Institute, Los Angeles
Introduction: Cardiac allograft vasculopathy (CAV) continues to limit the long-term success of heart transplantation. Although the progression of CAV can be slowed by tailored immunosuppression,…2017 American Transplant Congress
Myocardial Improvement Six Months After Kidney Transplantation: Non-Contrast Cardiac Resonance Study.
Internal Medicine, Botucatu School of Medicine, Botucatu, Sao Paulo, Brazil
INTRODUCTION: Patients with stage 5 chronic kidney disease (CKD) are at increased risk of cardiovascular disease, considering left ventricular hypertrophy (LVH) an independent risk for…2017 American Transplant Congress
Macrophage Specific Deletion of RhoA Inhibits Fractalkine Signaling and Abrogates Chronic Rejection of Cardiac Allograft.
Surgery, Houston Methodist Hospital and Research Institute, Houston
Objective. Chronic rejection of transplanted organs remains unresolved issue in organ transplantation. The chronic rejection is the most common cause of graft loss within 10…2017 American Transplant Congress
Everolimus Reduces Carotid Intima-Media Thickness in Renal Transplant Recipients After One Year: Randomized Controlled Trial.
Cardiovascular disease remains the commonest cause of death in kidney transplant recipients. Although some studies suggest that Mammalian target of rapamycin (mTOR) inhibitors may reduce…2017 American Transplant Congress
HCC and Cardiac Cirrhosis After the Fontan Procedure in a Patient with Congenital Heart Disease and Situs Inversus.
Division of Abdominal Transplantation, Baylor College of Medicine, Houston, TX
Introduction. Hypoplastic left heart syndrome (HLHS) is a fatal congenital cardiac anomaly for which surgical palliation is needed, the Fontan procedure. HLHS accounts for <5%…2017 American Transplant Congress
Carotid Intima-Media Thickness and Myocardial Strain in Pediatric Kidney Transplant Recipients.
Children's National, Washington DC
A prospective controlled longitudinal study was conducted to investigate determinants of carotid intima-media thickness (CIMT) and myocardial strain in children after kidney transplant (Tx).Methods: 42…2017 American Transplant Congress
A Promising MyD88 Inhibitor TJ-M2010-2 Protects Heart from Myocardial Ischemia Reperfusion Injury.
BACKGROUND: The activation of innate immunity via myeloid differentiation factor 88 (MyD88) contributes to myocardial ischemia reperfusion injury (IRI). This study is to investigate the…2017 American Transplant Congress
Deleting LAG-3 Accelerates Cardiac Allograft Rejection and Augments T Cell Memory in Mice.
Purpose: Lymphocyte Activation Gene-3 (LAG-3) expresses a transmembrane receptor on activated immune cells such as T cells, NK cells, and plasmacytoid dendritic cells. It is…
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