Articles tagged "Heart"

2017 American Transplant Congress
A Promising MyD88 Inhibitor TJ-M2010-2 Protects Heart from Myocardial Ischemia Reperfusion Injury.
Y. Miao, L. Xie, X. Zhang, Z.-C. Ding, M. Yang, Y. Yang, P. Zhou.
Institute of Qrgan Transplantation, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology; Key Labrory of Organ Transplantation, Wuhan, Hubei, China
BACKGROUND: The activation of innate immunity via myeloid differentiation factor 88 (MyD88) contributes to myocardial ischemia reperfusion injury (IRI). This study is to investigate the…
2017 American Transplant Congress
Deleting LAG-3 Accelerates Cardiac Allograft Rejection and Augments T Cell Memory in Mice.
J. Erfe,^1,2 C. Yang,¹ D. Ndishabandi,¹ I. Rosales,¹ R. White,¹ P. Russell,¹ R. Colvin,¹ J. Madsen,¹ A. Alessandrini.¹
¹Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA; ²Yale School of Medicine, New Haven, CT
Purpose: Lymphocyte Activation Gene-3 (LAG-3) expresses a transmembrane receptor on activated immune cells such as T cells, NK cells, and plasmacytoid dendritic cells. It is…
2017 American Transplant Congress
Mitochondrial Permeability Can Regulate Endothelial Cell Necroptosis and Promote Cardiac Allograft Rejection.
I. Gan,^1,2 J. Jiang,¹ D. Lian,¹ A. Jevnikar,^1,3 Z.-X. Zhang.^1,2
¹Matthew Mailing Centre for Translational Transplant Studies, Western University, London, ON, Canada; ²Department of Pathology and Laboratory Medicine, Western University, London, ON, Canada; ³Department of Medicine, Western University, London, ON, Canada
Background: Transplant injury is invariably associated with programmed cell death (PCD) resulting in organ rejection. Many forms of PCD have been described including apoptosis, pyroptosis,…
2017 American Transplant Congress
IL-3 Contributes to Development of Basophil-Triggered Cardiac Allograft Fibrosis Development.
G. Schiechl-Brachner,¹ M. Rodriguez Gomez,¹ K. Renner,¹ S. Buchtler,¹ K. Schmidbauer,¹ D. Halbritter,¹ S. Neumayer,¹ Y. Talke,¹ H. Bruehl,² M. Mack.¹
¹Department of Internal Medicine II, University Hospital / Medical Center, Regensburg, Germany; ²Department of Internal Medicine I, University Hospital / Medical Center, Regensburg, Germany
Introduction: Organ fibrosis and vasculopathy are major causes of chronic cardiac allograft failure. Resident (donor-derived) fibroblasts are thought to be mainly responsible for excessive production…
2017 American Transplant Congress
Donor Macrophage Depletion from CMV-Latently Infected Hearts Abrogates CMV-Accelerated Chronic Rejection.
J. Burg,¹ T. Andoh,² N. Haese,² I. Jones,² S. Orloff,¹ D. Streblow.²
¹Department of Surgery, OHSU, Portland, OR; ²VGTI, OHSU, Hillsboro, OR
Purpose: Latent donor CMV infection has been shown to accelerate chronic rejection (CR) in a heterotopic rat heart transplant model. CMV latency is associated with…
2017 American Transplant Congress
To Accept or Not Accept, That Is the Question: Donor Heart Selection Process and Outcome of Discarded Organs Transplanted in Another Center.
A. Aliabadi-Zuckermann,¹ J. Goekler,¹ A. Kaider,² J. Riebandt,¹ R. Moayedifar,¹ E. Osorio,¹ T. Haberl,¹ G. Laufer,¹ J. Smits,³ A. Zuckermann.¹
¹Cardiac Surgery, Medical University of Vienna, Vienna, Austria; ²Center for Medical Statistics, Informatics and Intelligent Systems, Medical University of Vienna, Vienna, Austria; ³Eurotransplant Foundation, Leiden, Netherlands
Purpose: The decision making process to accept a donor heart is very complicated, subjective and less associated with evidence based decisions. In this analysis we…
2017 American Transplant Congress
Statins in Liver Transplant Recipients: Rates of Use, Mortality and Rejection.
R. Selim,¹ A. Abdulhamid,¹ A. Shyamraj,² A. Watson,² J. Tang,² S.-M. Jafri.²
¹Internal Medicine, Henry Ford Hospital, Detroit, MI; ²Gastroenterology, Henry Ford Hospital, Detroit, MI
Introduction:Liver transplant recipients are prone to developing metabolic syndrome following transplant, likely secondary to immunosuppressant use. Among those with metabolic syndrome, the rate of cardiovascular…
2017 American Transplant Congress
Minimal Effect of Broader Heart Sharing on Regional Outcomes.
A. Bitar,¹ M. Skeans,² R. Davies,³ M. Farr,⁴ A. Kao,⁵ L. Robbins-Callahan,⁶ J. Rogers,⁷ S. Silvestry,⁸ M. Colvin.^1,2
¹U of MI, Ann Arbor, MI; ²SRTR, Mpls, MN; ³Nemours/AIDHC, Wilmington, DE; ⁴Columbia U, NY, NY; ⁵Mid-America Heart Inst, KC, MO; ⁶UNOS, Richmond, VA; ⁷Duke U, Durham, NC; ⁸FL Hosp Transplant Inst, Orlando, FL
The OPTN/UNOS Heart Subcommittee proposed a revision to policy 6 (Allocation of Hearts and Heart-Lungs) to better address heart transplant candidate medical urgency. They developed…
2017 American Transplant Congress
Malignancy in Patients Undergoing Simultaneous Heart-Liver and Heart-Kidney Transplant.
A. Chin, A. Habertheuer, A. Chou, M. Acker, M. Williams, P. Atluri, C. Bermudez, P. Vallabhajosyula.
University of Pennsylvania, Philadelphia, PA
Purpose: While evidence suggests that patients undergoing simultaneous heart-liver and heart-kidney transplant may have improved immunoprotection from allograft rejection versus patients undergoing heart transplant only,…
2017 American Transplant Congress
Trends in the Number and Medical Urgency of Adult Heart Transplant Candidates Listed as Status 1A from 2006-2015.
W. Parker,¹ M. Churpek,¹ S. Fedson,² E. Garrity.¹
¹Pulmonary and Critical Care, University of Chicago, Chicago, IL; ²Baylor College of Medicine, Houston, TX
The wider geographic sharing of hearts in 2006 may have had unintended consequences for transplant center listing behavior. This project examines trends in the number…