Articles tagged "Heart preservation"

2020 American Transplant Congress
Successful Transplantation of Murine Hearts Preserved 24h Under Subzero Ischemia Using Novel Bio-Inspired Next Generation Cryoprotectants
B. Oh¹, A. Callegari², M. Kline², A. Childs², M. Iglesias Lozano¹, G. Brandacher¹, X. Wei²
¹Department of Plastic and Reconstructive Surgery, Vascularized Composite Allotransplantation (VCA), Johns Hopkins University School of Medicine, Baltimore, MD, ²X-Therma Inc., Richmond, CA
*Purpose: Extension of the organ ischemia window is of paramount importance to prolong viability of transplantable organs and to improve overall outcomes. Transport using a…
2020 American Transplant Congress
Ex Vivo Pumping Through an OPO’s Eyes
A. L. Friedman, E. Marquez
LiveOnNY, New York, NY
*Purpose: A single, large organ procurement organization (OPO) sought to document the use of extra-renal ex vivo pumping in the management of the deceased donor…
2019 American Transplant Congress
Mitochondrial Permeability Regulates Heart Graft Ischemia – Reperfusion Injury and Rejection
A. Qamar¹, J. Jiang¹, X. Huang², P. McLeod², A. M. Jevnikar², Z. Zhang²
¹Pathology and Laboratory Medicine, University of Western Ontario, London, ON, Canada, ²London Health Sciences Centre, London, ON, Canada
*Purpose: A growing body of evidence indicates that mitochondrial permeability transition pore (mPTP) formation plays a crucial role in necroptosis - a programmed form of…
2019 American Transplant Congress
Erk-elk1-mir-711 Signalling In Cardiac Ischemia Reperfusion Injury In Heart Transplantation
H. Zheng, Y. Su, C. Zhu, V. Veramkovich, X. Zheng
Pathology, University of Western Ontario, London, ON, Canada
*Purpose: This study aims to discover new molecular mechanisms involved in and to develop new treatment for preventing ischemia reperfusion injury in heart transplantation.*Methods: The…
2019 American Transplant Congress
Activation of Oxidative Stress-Adoptive Responses during Extended Ex Situ Heart Perfusion
S. Hatami, X. Qi, M. Buchko, C. W. White, S. Bozso, S. Himmat, J. Nagendran, D. H. Freed
Department of Surgery, University of Alberta, Edmonton, AB, Canada
*Purpose: Cardiac function declines in a time-related fashion during ex situ heart perfusion (ESHP) regardless of ventricular load status. We have previously shown that the…
2019 American Transplant Congress
Correlation between Gene Expression and Cardiac Function in Ex Vivo Perfused Porcine Hearts
S. Rotich, N. Herbers, S. Hatami, J. Nagendran, M. Mengel, D. Freed, B. Adam
University of Alberta, Edmonton, AB, Canada
*Purpose: Cardiac transplantation is a life-saving intervention for advanced heart failure but it is limited by a shortage of suitable donor organs. Ex vivo heart…
2019 American Transplant Congress
Supercooling Preservation Prolonged Mouse Cardiac Graft Cold Ischemia Time
W. Que¹, X. Hu¹, M. Fujino¹, Y. Yamada², L. Zhong³, X. Li¹
¹Division of Transplantation Immunology, National Research Institute for Child Health and Development, Tokyo, Japan, ²Technican Co., Ltd., Kanagawa, Japan, ³Department of Surgery, Shanghai General Hospital, shanghai Jiao Tong University School of Medicine, Shanghai, China
*Purpose: Supercooling preservation techniques store a donor organ below 0°C without freezing. This has great advantages in inhibiting metabolism and preserving the organ in comparison…
2018 American Transplant Congress
Ischemia Reperfusion Injury Significantly Differs between Lung vs. Heart Transplantation with Respect to Lead Cytokines and Correlation to Clinical Outcome
B. Wiegmann,¹ N. Ledwoch,² J. ISke,² C. Neudörfl,² I. Tudorache,¹ C. Kühn,¹ T. Kaufeld,¹ F. Ius,¹ S. Rojas,¹ M. Avsar,¹ A. Haverich,¹ G. Warnwcke,¹ C. Falk.¹
¹Department of Cardiothoracic Transplantation and Vascular Surgery, Hannover Medical School, Hannover, Germany; ²Institute of Transplant Immunology, Hannover Medical School, Hannover, Germany.
ObjectivesIschemia reperfusion injury (IRI) is known to impair early graft function after lung (LTx) or heart (HTx) transplantation. We have previously characterized IRI in lungs…
2018 American Transplant Congress
Hemodynamic and Functional Analysis of Human DCD Hearts Undergoing Normothermic Ex Vivo Perfusion
W. Sommer, N. Roy, S. Kilmarx, J. O., J. Titus, M. Villavicencio, J. Stone, J. Madsen, D. D'Alessandro.
Massachusetts General Hospital, Boston.
Heart donation after circulatory death (DCD) is feasible although little is known about the hemodynamic and functional parameters of these marginal donor organs. We conducted…
2018 American Transplant Congress
Potential Impact of DCD Donor Recoveries on Heart Transplantation: Retrospective Analysis of a Limited UNOS Dataset
J. Lindower,² M. Farr,¹ S. Taylor,² U. Jorde,³ L. Chen,⁴ A. Gass,⁵ L. Truby,¹ S. Delair,² S. Pinney.⁶
¹New York Cardio-Thoracic Transplant Consortium, Troy, NY; ²Columbia/New York Presbyterian Hospital, New York; ³Montefiore Medical Center, Bronx, NY; ⁴Rochester University Medical Center, Rochester, NY; ⁵Westchester Medical Center, Valhalla, NY; ⁶Mount Sinai Medical Center, New York, NY.
Purpose: To review the volume and quality of potential DCD (Donation after Cardiac Death) Heart Transplant (HT) donors in the US, evaluate trends over time…