Articles tagged "Heart preservation"

2022 American Transplant Congress
Novel Portable Hypothermic Cardiac Preservation Device Enhances Cardiac Viability and Function of the Isolated Porcine Hearts
K. Andrijauskaite, R. J. Veraza, R. P. Lopez, E. C. Cisneros, I. J. Jessop, M. D. Watt, L. Bunegin
Vascular Perfusion Solutions, Inc, San Antonio, TX
*Purpose: Cardiac heart transplantation is the gold standard for treating end-stage heart failure; however, the list of patients waiting for heart transplants continues to increase.…
2022 American Transplant Congress
Does Machine Perfusion of Heart for Donation After Cardiac Death (DCD) Transplantation Affect Other Organ Outcomes?
R. Misawa¹, K. Okumura², H. Sogawa¹, G. Veillette¹, A. Dhand³, R. Bodin⁴, D. C. Wolf⁴, B. Partiula⁴, D. John¹, T. Diflo⁵, S. Nishida¹
¹Department of Surgery, Transplant, Westchester Medical Center/New York Medical College, Valhalla, NY, ²Surgery, Westchester Medical Center/New York Medical College, Valhalla, NY, ³Department of Medicine, Westchester Medical Center/New York Medical College, Valhalla, NY, ⁴Medicine, Westchester Medical Center/New York Medical College, Valhalla, NY, ⁵Westchester Medical Center/New York Medical College, Valhalla, NY
*Purpose: Machine perfusion of heart for donation after cardiac death (DCD) transplants is being increasingly utilized. Initial protocol of the heart machine perfusion for the…
2021 American Transplant Congress
Pig Orthotopic Heart Transplantation (ohtx) in Baboons: Is an Acute Pulmonary Inflammatory Response the Key Problem?
A. Jagdale¹, D. Cleveland², M. Bikhet¹, J. Foote³, G. Walcott⁴, H. Iwase¹, T. Yamamoto¹, H. Hara¹, C. Hansens-Estruch¹, D. Ayares⁵, S. Litovsky⁶, L. Rhodes², W. Carlo⁷, J. Crawford², R. Dabal², S. Borasino², D. Cooper¹
¹Surgery, University of Alabama at Birmingham, Birmingham, AL, ²Cardiothoracic Surgery, Children's of Alabama, Birmingham, AL, ³Medicine and Cardiovascular Diseases, University of Alabama at Birmingham, Birmingham, AL, ⁴Medicine, University of Alabama at Birmingham, Birmingham, AL, ⁵Surgery, Revivicor, Blacksburg, VA, ⁶Pathology, University of Alabama at Birmingham, Birmingham, AL, ⁷Division of Pediatric Cardiology, Department of Pediatrics, University of Alabama at Birmingham, Children's of Alabama, Birmingham, AL
*Purpose: To investigate the mechanism of early cardio-pulmonary dysfunction after genetically engineered pig OHTx in baboons.*Methods: OHTx from pigs expressing different genetic modifications, α‐galactosyltransferase knockout…
2021 American Transplant Congress
Cold Perfusion for Ischemia Minimization Reduces Cardiac Injury in an Ex Vivo Xenoperfusion Model
M. R. Connolly¹, A. Calhoun¹, F. Pollok¹, L. Burdorf¹, Z. Habibabady¹, M. Ma¹, S. Miura¹, W. Eyestone², C. Phelps², D. Ayares²
¹Massachusetts General Hospital, Boston, MA, ²Revivicor, Blacksburg, VA
*Purpose: Prior studies using Steen’s cold perfusion storage technique for heart ischemia minimization (IM) prevented initial xenograft dysfunction (IXD). Our pilot data evaluates the effect…
2020 American Transplant Congress
Comparing Two Methods of Minimally-Ischemic Cardiac Preservation in Life-Supporting Cardiac Xenotransplantation Model
C. E. Goerlich¹, A. Singh¹, D. Kaczorowski¹, M. Abdullah¹, B. Lewis¹, I. Tatarov¹, A. Hershfeld¹, T. Zhang¹, E. Strauss¹, P. Odonkor¹, B. Williams¹, D. Ayares², B. Griffith¹, M. Mohiuddin¹
¹Surgery, University of Maryland School of Medicine, Baltimore, MD, ²Surgery, Revivicor, Blacksburg, VA
*Purpose: Transplantation of organs from animals to humans (xenotransplantation) has been proposed to address the critical shortage of organs for transplantation. The use of genetically…
2020 American Transplant Congress
Cardiac Transplantation is Accompanied by Major T and NK Cell Alterations within the First 24 Hours
J. Iske¹, B. Wiegmann², K. Ludwig¹, N. Ledwoch¹, E. Chichelnitskiy¹, J. F. Kühne¹, A. Hitz¹, R. Bellmàs-Sanz¹, K. Daemen¹, J. Keil¹, F. Ius², S. Rochas², A. Knoefel², A. Haverich², G. Warnecke², C. S. Falk¹
¹Institute of Transplant Immunology, Hannover Medical School, Hannover, Germany, ²Division of Cardiac, Thoracic, Transplantation and Vascular Surgery, Hannover Medical School, Hannover, Germany
*Purpose: Allogeneic heart transplantation (HTx) displays the only curative approach for terminal heart insufficiency while acute allograft rejection remains a major complication. However, early kinetics…
2020 American Transplant Congress
The Effect of UNOS Donor Policy Change on Ischemic Time and the Effects on Mortality in Heart Transplantation
A. Lee¹, K. Yang¹, G. Liu¹, C. Lum², A. D. Salimbangon³, R. R. Chand⁴, P. Banankhah¹, P. Genyk¹, P. Kingsford¹, J. Li¹, J. Li¹, D. Vucicevic⁵, K. Pandya¹, J. Rahman¹, M. Fong¹, L. Grazette¹, A. Kiankhooy¹, J. [email protected]¹, S. Hashmi¹, A. Gong¹, J. Pizula¹, D. Miklin¹, S. Shah¹, A. Vaidya¹, A. Wolfson⁶, E. Depasquale¹
¹Keck Medicine of USC, Los Angeles, CA, ²The Queens Medical Center, Honolulu, HI, ³UCLA Medical Center, Los Angeles, CA, ⁴Harbor-UCLA Medical Center, Los Angeles, CA, ⁵Newark Beth-Israel Medical Center, Newark, NJ, ⁶University of Arizona Sarver Heart Center, Tuscon, AZ
*Purpose: In light of the recent change in the UNOS allocation policy, we sought to evaluate the impact of ischemic time on mortality.*Methods: Using the…
2020 American Transplant Congress
First Experience with a New Storage Device for Cold Heart Preservation
A. Zuckermann, J. Gökler, P. Kaiser, E. Ceran, N. Neuber, P. Angleitner, G. Laufer, A. Aliabadi-Zuckermann
Department of Cardiac Surgery, Medical University of Vienna, Vienna, Austria
*Purpose: The standard technology for heart preservation for transplantation is cold static storange on ice. No temperature control is performed routinley and therefore lower or…
2020 American Transplant Congress
First U.S. DCD Heart Procured/Transplanted after Normothermic Regional Perfusion
A. L. Friedman¹, Z. N. Kon², D. E. Smith², B. Sullivan³, J. Carillo², N. Moazami²
¹LiveOnNY, New York, NY, ²Cardiothoracic Surgery, NYU Langone Transplant Institute, New York, NY, ³NYU Langone Transplant Institute, New York, NY
*Purpose: We successfully planned, procured and transplanted a heart after a Donation After Cardiac Death (DCD) protocol with post-declaration implementation of in vivo cardiopulmonary bypass…
2020 American Transplant Congress
Making History, Saving Lives: One OPOs Experience Making History by Being the First in the Nation to Successfully Allocate Seven Organs for Transplant from a Donation after Circulatory Death (DCD) Donor
J. B. Nave, A. J. Boyer, C. A. Hostetler, C. C. Muse, R. A. Squires, J. P. Orlowski
LifeShare Transplant Donors Services, Oklahoma City, OK
*Purpose: At the time of this recovery, our OPO’s percentage of DCD donors was 41%. Continuing to maximize the gift successfully by increasing the percentage…