ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Growth factors"

  • 2020 American Transplant Congress

    Hepatocyte Growth Factor (HGF) Prevents the Apoptotic and Anti-Angiogenic Effect of Hypercholesterolemia on Hepatocytes in Liver Allografts

    H. B. Ozdemir1, G. Ozgun1, A. Yucel Polat1, N. Haberal1, G. Moray2, M. Haberal2

    1Pathology, Baskent University, Ankara, Turkey, 2Department of General Surgery, Division of Transplantation, Baskent University, Ankara, Turkey

    *Purpose: Background: Hypercholesterolemia (HC) impairs angiogenesis and induces apoptosis in livers. This hyperlipidemic impairment of angiogenesis reported associated with reduced bFGF. HGF stimulates proliferation, angiogenesis,…
  • 2020 American Transplant Congress

    Bone Marrow Mesenchymal Stem Cells Improve Rat Islet Angiogenesis by Upregulating of ISL1 and VEGF-A

    Y. Wang1, J. Wang2, X. Ding2

    1Department of Renal Transplantation, Nephropathy Hospital, The First Affiliated Hospital of Xi'an Jiaotong University, Xi’an, China, 2Department of Renal Transplantation, Nephropathy Hospital, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China

    *Purpose: Islet transplantation is an important therapy to cure diabetes, but poor angiogenesis in the early stage of islet transplantation is one of the main…
  • 2020 American Transplant Congress

    Multifactorial Effect of Hepatocyte Growth Factor (HGF) on the Microscopic Regeneration of Liver Allograft in Recipients Who Underwent Transplantation from Living Donors

    B. H. Ozdemir1, G. Ozgun1, A. Yucel Polat1, M. Haberal2

    1Pathology, Baskent University, Ankara, Turkey, 2Department of General Surgery, Division of Transplantation, Baskent University, Ankara, Turkey

    *Purpose: Although partial liver allografts from living donors have near-complete regeneration of their liver volumes within weeks after transplantation, the microscopic range of regeneration is…
  • 2019 American Transplant Congress

    Stem Cell and Granulocyte- Colony Stimulating Factor Therapies to Improve Functional Outcomes in Limb Transplantation

    J. Weiss1, C. Phillips1, E. Malin1, V. Gorantla2, S. K. Salgar3

    1Surgery, Madigan Army Medical Center, Tacoma, WA, 2Surgery, Wake Forest University, Salem, NC, 3Clinical Investigation, Madigan Army Medical Center, Tacoma, WA

    *Purpose: Although, over 200 clinical Vascularized Composite Allotransplantation (VCA) such as hands, legs, and face have been performed worldwide, still there are many challenges such…
  • 2019 American Transplant Congress

    Pancreatic Extracellular Matrix Improves Human Islet Culture and Function In Vitro

    Y. Shindo, R. Pouillot, B. M. Young, P. Link, R. L. Heise, M. F. Levy, M. A. Kanak

    Virginia Commonwealth University, Richmond, VA

    *Purpose: Islet transplantation is a thriving therapy for patients with Chronic Pancreatitis and Type-1 Diabetes. Within the pancreas, the islets are surrounded by Extracellular Matrix…
  • 2019 American Transplant Congress

    Platelets Stimulate Liver Regeneration in a 30% Partial Liver Transplantation Model in Rat

    C. Liang, K. Takahashi, T. Oda, N. Ohkohchi

    University of Tsukuba, Tsukuba, Japan

    *Purpose: Thirty years after the first living donor liver transplantation (LDLT), this technique has been widely recognized as the golden standard in treatment of end-stage…
  • 2018 American Transplant Congress

    GDF15 Preventing Renal Ischemia Reperfusion Injury

    C. Zhu,1,2 A. Patel,1 Y. Su,1,2 J. Jiang,1 D. Lian,1 A. Sener,1 W. Min,1 P. Luke,1 D. Quan,1 K. Liu,2 X. Zheng.1

    1University of Western Ontario, London, ON, Canada; 2Jilin University, ChangChun, China.

    Rationale: Ischemia reperfusion (I/R) injury still remains one of main causes of early renal dysfunction in kidney transplantation. There are no effective treatments for preventing…
  • 2017 American Transplant Congress

    Induced Pluripotent Stem Cell (iPS) Derived Schwann Cells to Enhance Functional Recovery Following Nerve Injury and Limb Allotransplantation.

    B. Kern,1 K. Sarhane,2 Z. Ibrahim,2 B. Mukherjee-Clavin,3 J. Budihardjo,2 C. Cashman,3 K. Krick,4 S. Schneeberger,1 W. Lee,2 H.-Q. Mao,4 G. Lee,3 G. Brandacher.2

    1Operative Medicine, Innsbruck Medical University, Innsbruck, Austria; 2Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, MD; 3Neurology and Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD; 4Materials Science and Engineering, Johns Hopkins University School of Medicine, Baltimore, MD

    Background Stem cell therapies have provided new aspects for functional recovery. A novel cell-based approach utilizing human induced Pluripotent Stem Cell-derived Schwann Cells (iPSC-SCs) supported…
  • 2016 American Transplant Congress

    FGF and Wnt Signaling in Pancreatic Progenitor and Beta-Cell Growth.

    S. Afelik,1 N. Yonan,1 B. Pool,2 J. Jensen,2 J. Oberholzer.1

    1Surgery, Division of Transplantation, University of Illinois, Chicago, IL; 2Stem Cell Biology and Regenerative Medicine, Cleveland Clinic Foundation, Cleveland, OH.

    Beta-cell replacement therapy offersa cure for diabetes, but this is limited by the lack of readilyavailable supply of cells. Our goal is generate enough beta-cells…
  • 2016 American Transplant Congress

    Evaluation of the Utilization of Filgrastim in Kidney Transplant Recipients.

    T. Poon,1 C. Guerra.2

    1Pharmacy, Long Island University, Brooklyn, NY; 2Pharmacy, SUNY Downstate Medical Center, Brooklyn, NY.

    Purpose: Granulocyte colony-stimulating factors (G-CSF), such as filgrastim, stimulate the production, proliferation, and differentiation of neutrophils and are indicated for the treatment of neutropenia in…
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