2015 American Transplant Congress
Graft-Versus-Host Disease After Orthotopic Liver Transplantation: Multivariate Analysis of Risk Factors
Introduction:Acute graft versus host disease (GVHD) is a rare fatal complication following orthotopic liver transplantation (OLT). It involves activation of donor T lymphocytes by antigen…2015 American Transplant Congress
Severe Refractory Skin Eruption Treated With Plasmapheresis in a Multivisceral Transplant Patient
3 year old African American male who underwent a multivisceral transplant due to gastroschisis. Crossmatch for T and B cells, PRA, DSA were negative. Induction…2015 American Transplant Congress
Chimerism for Early Detection of Graft Versus Host Disease in Intestinal Transplantation
Miami Transplant Institute, University of Miami Miller School of Medicine, Miami, FL.
Graft versus host disease (GVHD) is a potentially fatal complication after multivisceral transplantation (MVT). By definition, donor cells must be present in the blood of…2015 American Transplant Congress
Human Gingival Tissue-Derived Mesenchymal Stem Cells Reduce Murine Acute GVHD Via Killing of Effector CD8+ Cells Through CD39/Adenosine A1R and A2BR Pathways
Human gingival tissue-derived mesenchymal stem cells (GMSCs) are a convenient source of MSCs that have been shown to treat autoimmune disease. Here we use human…2015 American Transplant Congress
T Cell Transfer With iNKT Cell Activation Facilitate Engraftment of Bone Marrow Cells Without GvHD
Contamination of allogenic T cells is considered to be a risk factor of graft versus host disease (GvHD) in bone marrow transplantation (BMT), whereas it…2015 American Transplant Congress
Etanercept for Graft Versus Host Disease Following Liver Transplantation
Purpose: Graft versus host disease (GVHD) is a devastating diagnosis and treatment options, such as antithymocyte globulin (ATG), have poor response rates. With a goal…2015 American Transplant Congress
Absence of Nucleotide-Binding Oligomerization Domain-Containing Protein 1 and 2 Modifies Adaptive Immune Responses
Background:The NOD family of intracellular pattern recognition receptors (PRRs) plays a key role in immune responses to microbial and danger signals. This family of proteins…2015 American Transplant Congress
ALDH Expression in Facilitating Cells Plays a Critical Role in Regulatory T Cell Induction and GVHD Prevention
Graft-vs-host disease (GVHD) is a major source of morbidity in hematopoietic stem cell transplantation (HSCT), limiting its application to treat nonmalignant hematopoietic diseases and to…2015 American Transplant Congress
T Cell C5a Receptor (C5aR) Signaling Regulates T Follicular Helper Cell (Tfh) Induction
Translational Transplant Research Center, Icahn School of Medicine at Mount Sinai, New York, NY.
Tfh cells, in part via IL-6 dependent production of IL-21, are specialized providers of B cell help. Extending previous work in which we showed that…2015 American Transplant Congress
Germinal Centre Autoimmunity Mediates Progression of Allograft Vasculopathy, With Essential Help Provided By T Follicular Cells
Dept of Surgery, University of Cambridge, Cambridge, United Kingdom.
Introduction: : In our previous work we have shown that donor CD4 T cells within heart grafts initiate anti-nuclear autoantibody responses. Here we clarify the…
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