Articles tagged "Graft survival"

2016 American Transplant Congress
Radiosensitive Cell Population Prolongs Graft Survival of Vascularized Composite Allografts in Non-Human Primates.
M. Uluer, J. Woodall, W. Hassanein, U. Drhu, B. Bojovic, A. Nam, S. Bartlett, R. Barth.
University of Maryland School of Medicine, Baltimore, MD.
Background: Vascularized composite allografts (VCA) containing vascularized bone marrow (VBM) prolong graft survival. To help elucidate this protective immunomodulatory effect, we irradiated donor facial VCA…
2016 American Transplant Congress
Renal Graft Survival According to Banff 2013 Diagnostic Categories in Indication Biopsies.
D. Redondo-Pachón,¹ C. Arias-Cabrales,¹ M. Pérez-Sáez,¹ J. Gimeno,² I. Sánchez-Güerri,² S. Bermejo,¹ A. Sierra,¹ C. Burballa,¹ M. Mir,¹ M. Crespo,¹ J. Pascual.¹
¹Nephrology, Hospital del Mar, Barcelona, Spain; ²Pathology, Hospital del Mar, Barcelona, Spain.
The impact of acute rejection in kidney graft survival is well known, but the prognosis of other diagnosis is uncertain. We evaluated the frequency and…
2016 American Transplant Congress
B Lymphocyte-Induced Maturation Protein-1 Promotes Allograft Survival via Modulation of T Cell Development.
A. Wang,¹ C. Loh,^1,3,4 S.-J. Chen,² C.-H. Lin,¹ H.-K. Sytwu,² S.-H. Chuang,¹ F.-C. Wei.^1,4
¹VCA; PRS Dept., CGMH, Taoyuan, Taiwan; ²Department of Microbiology and Immunology, NDMC, Taipei, Taiwan; ³Division of Surgery and Interventional Science, University College London, London, United Kingdom; ⁴College of Medicine, Chang Gung University, Taoyuan, Taiwan.
*Equal contributionPurposeVascularized composite allotransplantation (VCA) is a promising new field in plastic surgery. Skin is known to be the most immunogenic component of a composite…
2016 American Transplant Congress
Adopting the Kidney Donor Profile Index (KDPI)/Kidney Donor Risk Index (KDRI) for Japanese Donors After Cardiac Death.
M. Kusaka,¹ A. Kawai,¹ N. Fukami,¹ H. Sasaki,¹ H. Takahashi,² T. Ito,³ T. Kenmochi,³ R. Shiroki,¹ K. Hoshinaga.¹
¹Urology, Fujita Health University School of Medicine, Toyoake, Aichi, Japan; ²Division of Medical Statistics, Fujita Health University School of Medicine, Toyoake, Aichi, Japan; ³Organ Transplant Surgery, Fujita Health University School of Medicine, Toyoake, Aichi, Japan.
Introduction: Due to a severe organ shortage, it is important to predict the outcome of grafts prior to kidney transplantation and establish an appropriate allocation…
2016 American Transplant Congress
Allograft TLR4 Receptor Signaling Induces Specific Early Inflammatory Events in Promotes Allografts Subjected to Prolonged Cold Ischemic Storage.
T. Yagisawa, N. Kohei, D. Kish, R. Fairchild.
Dept. Immunology and Glickman Urological Institute, Cleveland Clinic, Cleveland, OH.
Engagement of Toll-like receptors (TLR) by endogenous danger-associated molecular pattern ligands contributes to the intensity of tissue inflammation, including the inflammation generated during ischemia-reperfusion injury…
2016 American Transplant Congress
iNKT Cell Ligands Administered with Bone Marrow Cells Expand Allo-Specific Regulatory T Cells In Vivo and Establish Transplant Tolerance.
S. Miyairi,^1,2 T. Hirai,¹ M. Okumi,¹ Y. Ishii,³ K. Yamazaki,² K. Tanabe.¹
¹Urology, Tokyo Women's Medical University, Tokyo, Japan; ²Cardiovascular Surgery, Tokyo Women's Medical University, Tokyo, Japan; ³Vaccine Design, RIKEN IMS-RCAI, Yokohama, Japan.
Invariant natural killer T(iNKT) cells have the powerful potential to expand regulatory T cells(Tregs), especially when they are presented α-galactosylceramide(aGC) by B cells. We previously…
2016 American Transplant Congress
Normothermic Ex-Vivo Perfusion of the Intestine: The Introduction of an Innovative Physiologic Model with Novel Biomarkers.
B. Soliman, T. Okamoto, C. Quintini, Q. Liu, M. Fujiki, A. Khanna, K. Hashimoto, J. Fung, K. Abu-Elmagd.
General Surgery, Transplant Center, Cleveland Clinic Foundation, Cleveland, OH.
Purpose: Ischemia reperfusion injury is a major risk factor for short and long-term functional survival after intestinal transplantation. Normothermic machine perfusion is an emerging biotechnology…
2016 American Transplant Congress
Angiotensin II Type 1 Receptor Antibodies Are Associated with Allograft Loss in Pediatric Renal Transplantation.
M. Pearl,¹ Q. Zhang,² M. Palma Diaz,³ J. Grotts,⁴ J. Brook,⁴ D. Gjertson,² P. Weng,¹ E. Reed,² E. Tsai.¹
¹Pediatrics, University of California-Los Angeles, Los Angeles, CA; ²Pathology and Laboratory Medicine, University of California-Los Angeles, Los Angeles, CA; ³Anatomic & Clinical Pathology, University of California-Los Angeles, Los Angeles, CA; ⁴Biostatistics, University of California-Los Angeles, Los Angeles, CA.
Background: Angiotensin II type 1 receptor antibody (AT1R-Ab) is associated with vascular injury and allograft failure in adult kidney transplantation. Its role in pediatric transplantation…
2016 American Transplant Congress
Clinical Significance of Isolated v1 Arteritis in Renal Transplantation.
D. Mikhail,^1,3 J. Wei,³ D. Kleinsteuber,² M. Gabril,^2,3 A. Sener,^1,3 M. Moussa,^2,3 P. Luke.^1,3
¹Department of Surgery, Division of Urology, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada; ²Department of Pathology and Laboratory Medicine, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada; ³Undergraduate Medicine, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.
INTRO: The presence of intimal arteritis (v) in renal transplant biopsies (Bx) establishes Grade II-III AVR (Acute Vascular Rejection) according to the Banff Classification. The…
2016 American Transplant Congress
Assessing the Induction of Tolerance to Vascularized Composite Allotransplantation in Miniature Swine.
J. Walch, J. Alonso-Escalante, H. Wang, B. Oh, M. Iglesias, A. Lee, G. Brandacher, G. Raimondi.
Plastic and Reconstructive Surgery, Johns Hopkins Medical Institute, Baltimore, MD.
Purpose: Miniature swine is a pre-clinical large animal model well suited to validate protocols of tolerance induction to vascularized composite allotransplantation (VCA). However, tools to…